RESUMEN
The therapeutic effects of antioxidant-loaded nanoemulsion can be often optimized by controlling the release rate in human body. Release kinetic models can be used to predict the release profile of antioxidant compounds and allow identification of key parameters that affect the release rate. It is known that one of the critical aspects in establishing a reliable release kinetic model is to understand the underlying release mechanisms. Presently, the underlying release mechanisms of antioxidants from nanoemulsion droplets are not yet fully understood. In this context, this review scrutinized the current formulation strategies to encapsulate antioxidant compounds and provide an outlook into the future of this research area by elucidating possible release mechanisms of antioxidant compounds from nanoemulsion system.
RESUMEN
Open-loop unstable systems with time-delays are often encountered in process industry, which are often more difficult to control than stable processes. In this paper, the stabilization by PID controller of second-order unstable processes, which can be represented as second-order deadtime with an unstable pole (SODUP) and second-order deadtime with two unstable poles (SODTUP), is performed via the necessary and sufficient criteria of Routh-Hurwitz stability analysis. The stability analysis provides improved understanding on the existence of a stabilizing range of each PID parameter. Three simple PID tuning algorithms are proposed to provide desired closed-loop performance-robustness within the stable regions of controller parameters obtained via the stability analysis. The proposed PID controllers show improved performance over those derived via some existing methods.