RESUMEN
Anti-inflammatory and regenerative effect of bioantioxidant complex from biomass of Panax ginseng was investigated. Extract from biomass of Panax ginseng with antioxidant action can neutralize the negative effects of free radicals. Complex had a strong regenerating and anti-inflammatory action first of all in the exudative phase of inflammation.
Asunto(s)
Inflamación/tratamiento farmacológico , Panax , Fitoterapia , Extractos Vegetales , Raíces de Plantas , Cicatrización de Heridas/efectos de los fármacos , Animales , Antioxidantes , Modelos Animales de Enfermedad , Relación Dosis-Respuesta a Droga , Vías de Administración de Medicamentos , Femenino , Masculino , Ratones , Resultado del Tratamiento , Heridas y Lesiones/tratamiento farmacológicoRESUMEN
The study of the geriatric properties of the bioantioxidant complex "Neovitin" received from a biomass of ginseng, against formation of radio gene tumors was continued. The preparation was applied to the laboratory animals exposed to chronic gamma irradiation by low doses, by all period of irradiation and thirty days in the post beam period. The expressed anticancerogenic effect of "Neovitin", reducing formation of radio gene tumors, including malignant, as well as reduction of a spectrum of new growths were proved.
Asunto(s)
Envejecimiento Prematuro/prevención & control , Antioxidantes/uso terapéutico , Neoplasias Inducidas por Radiación/prevención & control , Panax/química , Traumatismos Experimentales por Radiación/prevención & control , Protectores contra Radiación/uso terapéutico , Envejecimiento Prematuro/etiología , Envejecimiento Prematuro/patología , Animales , Antioxidantes/administración & dosificación , Antioxidantes/aislamiento & purificación , Suplementos Dietéticos , Rayos gamma/efectos adversos , Neoplasias Inducidas por Radiación/etiología , Neoplasias Inducidas por Radiación/patología , Extractos Vegetales/administración & dosificación , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/uso terapéutico , Traumatismos Experimentales por Radiación/complicaciones , Traumatismos Experimentales por Radiación/patología , Protectores contra Radiación/administración & dosificación , Protectores contra Radiación/aislamiento & purificación , RatasRESUMEN
The work starts studying the geriatric properties of the bioantioxidant complex "Neovitin" received from a biomass of ginseng, on model of accelerated radioactive aging. The preparation was applied before radioactive irradiation to study its preventive effect, and after irradiation to study the therapeutic effect. Efficiency of the complex was estimated by the survival rate of animals after irradiation in the experimental model. The increase in life expectancy of experimental animals as a result of preparation use is proved.
Asunto(s)
Envejecimiento/efectos de la radiación , Antioxidantes/farmacología , Panax , Fitoterapia , Preparaciones de Plantas/farmacología , Animales , Geriatría , Ratones , Modelos Animales , MortalidadRESUMEN
Possibility of isolating azaphen from the cadaveric material by acidified water and acetonitrile (as extractant) is shown. Isolation rate (75.6%) of azaphen (with 1 mg of preparation added to 25 g of the liver by acetonitrile is significantly higher than in isolation by acidified water (41.7%).
Asunto(s)
Antidepresivos Tricíclicos/análisis , Oxazinas/análisis , Antidepresivos Tricíclicos/aislamiento & purificación , Cadáver , Humanos , Hígado/análisis , Métodos , Oxazinas/aislamiento & purificaciónRESUMEN
Method of amitriptyline isolation from the cadaveric material using acetonitrile as extractant is suggested. This method makes it possible to extract in average 76.09% of substance previously added in quantity of 1 mg to 25 g of the liver. Method was successfully used in analysis of expert material.
Asunto(s)
Acetonitrilos , Amitriptilina/aislamiento & purificación , Cadáver , Humanos , Indicadores y Reactivos , Hígado/análisis , MétodosRESUMEN
The authors consider that the list of drugs and narcotics which can be reliably identified in a general forensic chemical analysis of cadaveric material (not a purposeful screening) should be changed. Isolation by acidified water, hydrochloric acid hydrolysis, and by acetonitrile should be used for isolation of drugs and narcotic compounds in forensic chemical analysis of cadaveric material.
Asunto(s)
Medicina Legal , Narcóticos/análisis , Preparaciones Farmacéuticas/análisis , Cadáver , Humanos , Psicotrópicos/análisis , Federación de RusiaRESUMEN
Analysis of the resultant mathematical models demonstrated that exposure of liver tissue to aqueous solutions of acids leads to an increase of pH, and its contact with alkaline solutions results in an appreciable decrease of the pH of the model system. This should be borne in mind when creating and analyzing analog models describing the process of extraction of various organic compounds from biological material.
Asunto(s)
Hígado/química , Modelos Biológicos , Cadáver , Medicina Legal/métodos , Medicina Legal/estadística & datos numéricos , Humanos , Concentración de Iones de Hidrógeno , Análisis de Regresión , Reproducibilidad de los Resultados , Soluciones , AguaRESUMEN
The authors have analyzed methodologic errors made by chemical experts in records of forensic chemical investigations selected at random. The major errors are classified and their frequency determined in relation to the complexity of the task. Suggestions are made aimed at improvement of the quality of forensic chemical investigations.
Asunto(s)
Técnicas de Química Analítica/normas , Medicina Legal/normas , Técnicas de Química Analítica/métodos , Medicina Legal/métodos , Control de Calidad , U.R.S.S.Asunto(s)
Amitriptilina/análisis , Hígado/análisis , Cromatografía de Gases , Humanos , Riñón/análisis , Estómago/análisisAsunto(s)
Química , Medicina Legal , Personal de Laboratorio Clínico/provisión & distribución , Química/estadística & datos numéricos , Escolaridad , Medicina Legal/estadística & datos numéricos , Humanos , Laboratorios/estadística & datos numéricos , Personal de Laboratorio Clínico/estadística & datos numéricos , U.R.S.S. , Recursos HumanosAsunto(s)
Química , Medicina Legal , Personal de Laboratorio Clínico , Adulto , Factores de Edad , Anciano , Química/estadística & datos numéricos , Medicina Legal/estadística & datos numéricos , Humanos , Laboratorios/estadística & datos numéricos , Personal de Laboratorio Clínico/estadística & datos numéricos , Persona de Mediana Edad , U.R.S.S. , Recursos HumanosAsunto(s)
Antiinflamatorios/uso terapéutico , Antioxidantes/uso terapéutico , Panax , Plantas Medicinales , Superóxido Dismutasa/uso terapéutico , Administración Tópica , Animales , Evaluación de Medicamentos , Evaluación Preclínica de Medicamentos , Humanos , Periodontitis/tratamiento farmacológicoAsunto(s)
Glicósidos Cardíacos/análisis , Lanatosidos/análisis , Adulto , Autopsia/métodos , Humanos , Masculino , Factores de TiempoAsunto(s)
Cabello/análisis , Mercurio/análisis , Población Urbana , Adolescente , Adulto , Factores de Edad , Anciano , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores Sexuales , U.R.S.S.RESUMEN
Under the influence of atmospheric pollutions certain structural-functional changes take place in placenta: terminal villi per stipulated square unite, villi with desquamated epithelium, with dilated vessels, with deposition of fibrinoid masses, with plasmodial buds increase in number; section area occupied by epithelial layer decreases; RNA concentration and histoenzymatic activity change in the latter.