1.
Org Lett
; 26(28): 5966-5971, 2024 Jul 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38958587
RESUMEN
The integration of umpolung and carbon isotope exchange for accessing isotopically labeled α-keto acids through photoredox catalysis is elucidated. This process involves the carbonyl umpolung of C(sp2)-α-keto acids to yield C(sp3)-α-thioketal acids, followed by the carbon isotope exchange of C(sp3)-α-thioketal acids, and ultimately, deprotection to generate carbon-labeled α-keto acids.