Asunto(s)
Antioxidantes/química , Alcaloides Indólicos/química , Monoterpenos/química , Rubiaceae/química , Antioxidantes/aislamiento & purificación , Antioxidantes/farmacología , Cristalografía por Rayos X , Alcaloides Indólicos/aislamiento & purificación , Alcaloides Indólicos/farmacología , Modelos Moleculares , Estructura Molecular , Monofenol Monooxigenasa/antagonistas & inhibidores , Monoterpenos/aislamiento & purificación , Monoterpenos/farmacología , Corteza de la Planta/química , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacologíaRESUMEN
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward ß-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50) 0.68 µM) showed inhibitory activity on ß-glucuronidase enzyme, while 3 (IC50) 7.69 µM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).
Asunto(s)
Antimaláricos/aislamiento & purificación , Antimaláricos/farmacología , Enoil-ACP Reductasa (NADH)/antagonistas & inhibidores , Ficus/química , Glucuronidasa/antagonistas & inhibidores , Isoflavonas/aislamiento & purificación , Isoflavonas/farmacología , Plasmodium falciparum/efectos de los fármacos , Plasmodium falciparum/enzimología , Antimaláricos/química , Camerún , Concentración 50 Inhibidora , Isoflavonas/química , Estructura MolecularRESUMEN
A phytochemical study of the stem bark of Vismia laurentii resulted in the isolation of a tetracyclic triterpene, tirucalla-7,24-dien-3-one (1), and seven other known compounds: 3-geranyloxyemodin (2), vismiaquinone A (3), vismiaquinone B (4), bivismiaquinone (5), epifriedelinol (6), betulinic acid (7) and stigmasta-7,22-dien-3-ol (8). The structure of all these compounds was elucidated by spectroscopic means. The stem bark extract and compounds 1 and 3 showed good antimalarial activity against the W2 strain of Plasmodium falciparum.
Asunto(s)
Antimaláricos/aislamiento & purificación , Clusiaceae/química , Tallos de la Planta/química , Antracenos/química , Antracenos/aislamiento & purificación , Antracenos/toxicidad , Antimaláricos/química , Antimaláricos/toxicidad , Camerún , Eritrocitos/efectos de los fármacos , Eritrocitos/fisiología , HumanosRESUMEN
Two anthraquinones, zenkequinones A and B were isolated from the stem bark of Stereospermum zenkeri together with known sterequinone-F, p-coumaric acid, sitosterol-3-O-beta-D-glucopyranoside and 3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside. Their structures were established by spectroscopic methods. The antimicrobial activity of the isolated compounds was evaluated against six multiresistant strains of pathogens. Zenkequinone B showed the best antibacterial activity (MIC 9.50 microg/ml) against gram-negative Pseudomonas aeruginosa.
Asunto(s)
Antraquinonas/farmacología , Antiinfecciosos/farmacología , Bignoniaceae/química , Antraquinonas/química , Antraquinonas/aislamiento & purificación , Antiinfecciosos/química , Antiinfecciosos/aislamiento & purificación , Ácidos Cumáricos/química , Ácidos Cumáricos/aislamiento & purificación , Ácidos Cumáricos/farmacología , Glucósidos/química , Glucósidos/aislamiento & purificación , Glucósidos/farmacología , Pruebas de Sensibilidad Microbiana , Corteza de la Planta/química , Propionatos , Pseudomonas aeruginosa/efectos de los fármacos , Sitoesteroles/química , Sitoesteroles/aislamiento & purificación , Sitoesteroles/farmacología , Triterpenos/química , Triterpenos/aislamiento & purificación , Triterpenos/farmacologíaRESUMEN
Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1α,2ß,8ß-triacetoxy-6ß,9ß-dibenzoyloxy-4ß-hydroxy-dihydro-ß-agarofuran), salaterpene B (2) (1α,2ß,8ß-triacetoxy-9ß-benzoyloxy-6ß-cinnamoyloxy-4ß-hydroxy-dihydro-ß-agarofuran), salaterpene C (3) (1α,2ß-diacetoxy-6ß,9ß-dibenzoyloxy-4ß-hydroxy-dihydro-ß-agarofuran) and salaterpene D (4) (2ß-acetoxy-1α,6ß-dibenzoyloxy-4ß-hydroxy-9ß-nicotinoyloxy-dihydro-ß-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 µM.