Validation of the Hospital for Sick Children Algorithm for Discriminating Bacteremia From Contaminants in Children With a Preliminary Positive Blood Culture.

STUDY OBJECTIVE: Children with positive blood cultures obtained in the emergency department (ED) prompt urgent actions due to the risk of bacteremia. This study aimed to validate the Hospital for Sick Children algorithm used for discriminating bacteremia from contaminants and identified variables associated with bacteremia in children with positive blood cultures. METHODS: We conducted a retrospective cohort study of all children with positive blood cultures from a tertiary care, pediatric ED between 2018 and 2022. A 2-step standardized approach defined true bacteremia as the primary outcome based on 1) the bacteria involved and 2) the clinical outcome assessed by 2 reviewers. We evaluated multiple independent variables. We used multiple logistic regression to analyze the association between independent variables and outcome. RESULTS: Among the 375,428 ED visits, 574 participants were identified, including 286 (49.8%; 95% confidence interval [CI] 45.8% to 53.9%) with bacteremia and 288 (50.2%; 95% CI 46.1% to 54.3%) with contaminants. The algorithm identified 364 children (63.4%) at high risk of bacteremia, 178 (31.0%) at medium risk, and 32 (5.6%) at low risk. The corresponding bacteremia proportions were 62%, 34%, and 0%, respectively, for a sensitivity of 100% and a specificity of 11%. Suspicion of osteoarticular infection (aOR=43.6; 95% CI 16.2 to 118), presence of internal hardware (aOR=24.9; 95% CI 7.2 to 83.5), and presence of Gram-negative bacteria or Gram-positive cocci in chains/pairs (aOR=21.7; 95% CI 11.7 to 40.3) were the most significant predictors of true bacteremia. CONCLUSION: The Hospital for Sick Children algorithm exhibits 100% sensitivity to detect children with bacteremia but demonstrated low specificity at 11%. We identified predictors to discriminate contaminants from bacteremia.

Incidence and Risk Factors of Systemic Adverse Effects and Complications of Ultrasound- and Fluoroscopy-Guided Glucocorticoid Injections: A Retrospective Cohort Study.

OBJECTIVES: The aims of the study are to assess the incidence of systemic adverse effects and complications of ultrasound-guided and fluoroscopy-guided glucocorticoid injections and to identify associated risk factors. DESIGN: This retrospective cohort study compared participants who received a glucocorticoid injection at the outpatient clinic and participants who had an appointment but did not receive a glucocorticoid injection. Participants were called to verify whether they had experienced any of the predetermined systemic adverse effects and complications. Multiple binary logistic regression was used to identify systemic adverse effect and complication risk factors. RESULTS: There were 1010 participants in the glucocorticoid injection group and 328 in the nonglucocorticoid injection group. There was no statistically significant difference in the occurrence of systemic infection and decompensated heart failure between the two groups. More participants in the glucocorticoid injection group developed abnormal uterine bleeding and erectile dysfunction, but the differences did not reach statistical significance. Female participants were 1.9 times more likely to develop systemic adverse effects ( P < 0.001). Younger age ( P < 0.001), diabetes ( P = 0.012), and higher glucocorticoid injection doses ( P = 0.024) were also associated with an increased risk of developing systemic adverse effects. CONCLUSIONS: Identified risk factors for developing glucocorticoid injection systemic adverse effects were younger age, female sex, diabetes, tobacco use, and high glucocorticoid injection doses.