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1.
Int Wound J ; 10(2): 193-9, 2013 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23136838

RESUMEN

Few studies regarding wound treatment with topical antimicrobials evaluate change in the bacterial bioburden of the wound with treatment. This study sought out to determine the in vivo effect of cadexomer iodine antibacterial dressing on diabetic foot ulcers (DFUs) that were infected or achieved a critical level of colonisation, looking specifically at wound progression in relation to bioburden. Fifteen patients corresponding to 16 total DFUs met criteria of displaying clinical signs of infection or critical colonisation and were suitable for a topical antibacterial dressing. They underwent weekly treatment for 6 weeks. Cultures were taken at week 0, 3 and 6 as appropriate. At week 6 median log10 bacterial count reduction of 1.0 was observed from baseline (p = 0·025). At week 3- a median log10 bacterial count reduction of 0.3 was observed from baseline (p = 0·049). Over the study period there was a 53.6% median reduction of the wound surface area. There were no patients that completely healed their ulcer over the 6 week study period. There was a statistically significant median reduction in the bacterial load over the 6 week period (p = 0·025) as well as 3 weeks (p = 0·049). This was accompanied by a median reduction of 53.6% in ulcer surface area and 50% in ulcer depth from baseline to final.


Asunto(s)
Antiinfecciosos Locales/administración & dosificación , Pie Diabético/tratamiento farmacológico , Yodóforos/administración & dosificación , Cicatrización de Heridas , Infección de Heridas/tratamiento farmacológico , Infección de Heridas/microbiología , Administración Tópica , Adulto , Anciano , Carga Bacteriana , Estudios de Cohortes , Pie Diabético/complicaciones , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Estudios Prospectivos
2.
Ostomy Wound Manage ; 55(2): 50-5, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19246785

RESUMEN

Modern dressings such as hydrocolloids, gels, and foams are typically more expensive than traditional dressings such as gauze. However, if modern dressings require fewer changes, the overall cost of treatment may be lower despite the higher initial purchase price. If healing rates are comparable or better, modern dressings also may be cost-effective. A 4-week, prospective, randomized clinical trial to assess differences in treatment costs and cost-effectiveness between a modern foam dressing and saline-soaked gauze was conducted among 36 patients (22 men, 14 women, mean age 72.8 years) with a Stage II pressure ulcer (mean duration 35 weeks) at five centers in the United States. Participants were randomized to treatment with a self-adhesive polyurethane foam (n = 20) or saline-soaked gauze dressing (n = 16). No difference in time to wound closure was observed (P = 0.817). Patients in the foam group had less frequent dressing changes (P <0.001). Total cost over the study period was lower by $466 per patient (P = 0.055) and spending on dressings was lower by $92 per patient in the foam group (P = 0.025). Cost per ulcer healed was lower by $1,517 and cost per ulcer-free day was lower by $80 for patients in the foam group. On the evidence of this study, the foam dressing is a more cost-effective treatment than saline-soaked gauze for the treatment of Stage II pressure ulcers.


Asunto(s)
Vendajes , Análisis Costo-Beneficio , Úlcera por Presión/terapia , Cloruro de Sodio/administración & dosificación , Femenino , Humanos , Masculino , Evaluación de Resultado en la Atención de Salud , Estudios Prospectivos , Estados Unidos
3.
J Am Podiatr Med Assoc ; 92(8): 425-8, 2002 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-12237262

RESUMEN

The lower-extremity amputation rate in people with diabetes mellitus is high, and the wound failure rate at the time of amputation is as high as 28%. Even with successful healing of the primary amputation site, amputation of part of the contralateral limb occurs in 50% of patients within 2 to 5 years. The purpose of this study was to provide valid outcome data before (control period) and 18 months after (test period) implementation of a multidisciplinary team approach using verified methods to improve the institutional care of wounds. Retrospective medical chart review was performed for 118 control patients and 116 test patients. The amputation rate was significantly decreased during the test period, and the amputations that were required were at a significantly more distal level. No above-the-knee amputations were required in 45 patients during the test period, compared with 14 of 76 patients during the control period. These outcome data suggest that unified care is an effective approach for the patient with diabetic foot problems.


Asunto(s)
Amputación Quirúrgica/estadística & datos numéricos , Pie Diabético/cirugía , Grupo de Atención al Paciente , Diabetes Mellitus Tipo 2/complicaciones , Pie Diabético/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento , Enfermedades Vasculares/complicaciones
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