Arenium-ion-catalysed halodealkylation of fully alkylated silanes.

'Organic silicon' is not found in nature but modern chemistry is hard to imagine without silicon bound to carbon. Although silicon-containing commodity chemicals such as those emerging from the 'direct process'1-4 look simple, it is not trivial to selectively prepare aryl-substituted and alkyl-substituted (functionalized) silicon compounds, known as silanes. Chlorosilanes such as Me4-nSiCln (n = 1-3) as well as SiCl4 (n = 4) are common starting points for the synthesis of silicon-containing molecules. Yet these methods often suffer from challenging separation problems5. Conversely, silanes with four alkyl groups are considered synthetic dead ends. Here we introduce an arenium-ion-catalysed halodealkylation that effectively converts Me4Si and related quaternary silanes into a diverse range of functionalized derivatives. The reaction uses an alkyl halide and an arene (co)solvent: the alkyl halide is the halide source that eventually engages in a Friedel-Crafts alkylation with the arene to regenerate the catalyst6, whereas the arenium ion acts as a strong Brønsted acid for the protodealkylation step7. The advantage of the top-down halodealkylation methodology over reported bottom-up procedures is demonstrated, for example, in the synthesis of a silicon drug precursor. Moreover, chemoselective chlorodemethylation of the rather inert Me3Si group attached to an alkyl chain followed by oxidative degradation is shown to be an entry into Tamao-Fleming-type alcohol formation8,9.

Chiral Carborane Acids Decorated with Binol-Based Phosphonates: Synthesis, Characterization, and Application.

The syntheses of hexabrominated closo-carborates decorated with different chiral Binol-derived phosphonates and their conjugate acids are described. X-ray diffraction analysis reveals a polymeric structure for the sodium salt with the anionic units connected by [B-Br-Na-O═P]+ linkages. For the acid, coordination of the proton to the phosphonate's P═O oxygen atom is assumed. The pKa value was estimated by combining experiments and computations. Application of these Brønsted acids as chiral catalysts in an imino-ene and a Mukaiyama-Mannich reaction was moderately successful.

Enantioselective Dearomatization of Pyridinium Salts by Copper-Catalyzed C4-Selective Addition of Silicon Nucleophiles.

A copper-catalyzed C4-selective addition of silicon nucleophiles released from an Si-B reagent to prochiral pyridinium triflates is reported. The dearomatization proceeds with excellent enantioselectivity using Cu(CH3CN)4PF6 as the precatalyst and (R,R)-Ph-BPE (1,2-bis[(2R,5R)-2,5-diphenylphospholan-1-yl]ethane) as the chiral ligand. A carbonyl group at C3 is required for this, likely acting a weak donor group to preorganize and direct the nucleophilic attack towards C4. The resulting 4-silylated 1,4-dihydropyridines can be further converted into functionalized piperidine derivatives.

Ring Contraction of Saturated Cyclic Amines and Rearrangement of Acyclic Amines Through Their Corresponding Hydroxylamines.

Compared to modifications at the molecular periphery, skeletal adjustments present greater challenges. Within this context, skeletal rearrangement technology stands out for its significant advantages in rapidly achieving structural diversity. Yet, the development of this technology for ring contraction of saturated cyclic amines remains exceedingly rare. While most existing methods rely on specific substitution patterns to achieve ring contraction, there is a persistent demand for a more general strategy for substitution-free cyclic amines. To address this issue, we report a B(C6F5)3-catalyzed skeletal rearrangement of hydroxylamines with hydrosilanes. This methodology, when combined with the N-hydroxylation of amines, enables the regioselective ring contraction of cyclic amines and proves equally effective for rapid reorganization of acyclic amine skeletons. By this, the direct scaffold hopping of drug molecules and the strategic deletion of carbon atoms are achieved in a mild manner. Based on mechanistic experiments and density functional theory calculations, a possible mechanism for this process is proposed.

Electrophilic Activation of S-Si Reagents by Silylium Ions for Their Regio- and Diastereoselective Addition Across C-C Multiple Bonds.

A regioselective silylium-ion-promoted thiosilylation of internal C-C triple bonds with control over the double bond geometry is described. Both a C(sp2)-S and a C(sp2)-Si bond are formed with a trans relationship in this two-component reaction of an alkyne and a thiosilane. The resulting orthogonally functionalized C-C double bond can be chemoselectively defunctionalized or further processed by cross-coupling reactions with the alkene configuration retained. The procedure is also applicable to the regio- and diastereoselective thiosilylation of terminal allenes to arrive at allylic thioethers containing a vinylsilane unit. These reactions involve the electrophilic activation of the S-Si reagent, both a silylated thiophenol and even alkylthiol derivative, by an in situ-generated carbocation intermediate. The catalytic cycle is maintained by a bissilylated aryl- or alkylsulfonium ion as a shuttle for the cationic silicon electrophile. Its independent preparation and structural characterization by X-ray diffraction are also reported.

Cationic Bis(hydrosilane)-Coinage Metal Complexes: Synthesis, Characterization, and Use as Catalysts for Outer-Sphere C=O Hydrosilylation Not Involving Metal Hydrides.

The preparation of cationic bis(hydrosilane)-coinage-metal complexes by chloride abstraction from the neutral metal chloride precursors with Na[BArF4] is described. Unlike previously reported hydrosilane-stabilized copper and silver complexes, the presented complexes are cationic and feature two bidentate ortho-(silylphenyl)phosphine ligands. These complexes were fully characterized by NMR spectroscopy and X-ray diffraction analysis, revealing that both Si-H bonds are activated by the Lewis acidic cationic metal center. The new complexes were found to be effective in catalytic carbonyl hydrosilylation, leading to the corresponding silyl ethers under mild conditions without the addition of an external base. Combined mechanistic control experiments and quantum chemical calculations support an ionic outer-sphere mechanism, in which a neutral metal alkoxide species instead of a metal hydride is the key intermediate that interacts with the silylcarboxonium ion to generate the silyl ether.

Catalytically Generated Meerwein's Salt-Type Oxonium Ions for Friedel-Crafts C(sp2)-H Methylation with Methanol.

A catalytic protocol for a Friedel-Crafts-type direct C(sp2)-H methylation of various arenes with methanol is disclosed. The reaction is initiated by counteranion-stabilized silylium or arenium ions, which form Meerwein's salt-like oxonium ions with methanol as the active methylating agents. The silylated methyloxonium ions are stronger electrophiles than their protonated congeners, allowing the Friedel-Crafts alkylation to proceed more efficiently and at a lower reaction temperature. The regeneration of these superelectrophiles within the catalytic cycle is accomplished by the addition of a tetraorganosilane additive, i.e., trimethyl(phenyl)silane or tetraethylsilane, that releases a silylium ion through protodesilylation by the Brønsted acidic Wheland intermediate, thereby acting as a productive "proton-into-silylium ion" generator. By this method, even the C-H methylation of electronically deactivated aryl halides with methanol is achieved. The protocol is also applicable to nonactivated primary as well as π-activated benzylic alcohols. Dialkyl ethers are also competent alkylating agents in the presence of the quaternary phenylsilane additive.

B(C6 F5 )3 -Catalyzed Regioselective Ring Opening of Cyclic Amines with Hydrosilanes.

Opening the ring of cyclic amines by regioselective fission of one of the carbon-nitrogen bonds greatly expands the repertoire of available nitrogen-containing skeletons. Unlike approaches starting from cyclic tertiary amines, methods that can directly open secondary amines are still scarce. The present work discloses an efficient reductive ring opening of either of these cyclic amines using PhSiH3 under B(C6 F5 )3 catalysis. By this, the direct transformation of unstrained cyclic amines into the corresponding acyclic amines is achieved in a simple one-pot operation. A stepwise mechanism proceeding through the intermediacy of silylammonium ions followed by reductive cleavage of a carbon-nitrogen bond was experimentally verified.

Bond-Forming Processes Enabled by Silicon-Masked Aryl- and Alkyl-Substituted Diazenes.

Aryl- and alkyldiimides (R-N═NH with R = aryl or alkyl) are elusive intermediates of valuable synthetic use, as they are assumed to be transient species in processes involving both carbon (with concomitant loss of N2) and nitrogen nucleophiles (with conservation of the N═N moiety). The actual compounds are fragile and as such not bench stable which is why they have not yet found the attention they deserve. Conversely, early contributions showed that the stability of the parent diimide is significantly increased by replacing the hydrogen atom by a silyl group, but the synthetic applicability of these silicon-protected aryl- and alkyldiazenes has been far less explored, in part due to the absence of general procedures for their preparation. This Perspective provides an overview of the underexplored diazene chemistry that has witnessed considerable progress in recent years and highlights the potential of this motif in a range of synthetically useful (catalytic) transformations. The rediscovered silicon-masked diazenes constitute a versatile platform possessing enhanced stability and tamed reactivity in comparison to the parent hydrogen-substituted diimides. Aryl, diazenyl, and alkyl anionic key intermediates can be selectively generated in situ under Lewis base or transition metal catalysis, giving rise to novel synthetic approaches as viable alternatives to the already existing methodologies.

Dehydrative Coupling of 1,1-Diarylalkenes and Cyclohexa-2,5-diene-1-carbaldehyde Derivatives Induced by a B(C6F5)3-Initiated [1,2]-Alkyl Migration.

A four-step formal ipso allylation of benzoic acid derivatives involving a B(C6F5)3-initiated and proton-catalyzed [1,2]-alkyl shift as part of a dehydrative coupling of cyclohexa-2,5-diene-1-carbaldehyde derivatives and 1,1-diarylalkenes is reported. By this, a series of allyl arenes can be regioselectively obtained from readily available benzoic acids in good yields.

Intramolecular 7-endo-dig-Selective Carbosilylation of Internal Alkynes Involving Silylium-Ion Regeneration.

A catalytic silylium-ion-promoted intramolecular alkyne carbosilylation reaction is reported. The ring closure is initiated by electrophilic activation of the C-C triple bond by a silylium ion, and the catalytic cycle is then maintained by the protodesilylation of a stoichiometrically added allylsilane reagent. Exclusive 7-endo-dig selectivity is seen, leading to a series of silylated benzocycloheptene derivatives with a fully substituted vinylsilane. Control experiments showed that the catalytically active silylium ion can also be regenerated by protodesilylation of the vinylsilane product.

Silylium Ions: From Elusive Reactive Intermediates to Potent Catalysts.

The history of silyl cations has all the makings of a drama but with a happy ending. Being considered reactive intermediates impossible to isolate in the condensed phase for decades, their actual characterization in solution and later in solid state did only fuel the discussion about their existence and initially created a lot of controversy. This perception has completely changed today, and silyl cations and their donor-stabilized congeners are now widely accepted compounds with promising use in synthetic chemistry. This review provides a comprehensive summary of the fundamental facts and principles of the chemistry of silyl cations, including reliable ways of their preparation as well as their physical and chemical properties. The striking features of silyl cations are their enormous electrophilicity and as such reactivity as super Lewis acids as well as fluorophilicity. Known applications rely on silyl cations as reactants, stoichiometric reagents, and promoters where the reaction success is based on their steady regeneration over the course of the reaction. Silyl cations can even be discrete catalysts, thereby opening the next chapter of their way into the toolbox of synthetic methodology.

Copper-Catalyzed Highly Enantioselective Addition of a Silicon Nucleophile to 3-Substituted 2H-Azirines Using an Si-B Reagent.

3-Substituted 2H-azirines can be considered strained cyclic ketimines, and highly enantioselective addition reactions of silicon nucleophiles to either acyclic or cyclic ketimines have been elusive so far. The present work closes this gap for those azirines by means of a copper-catalyzed silylation using a silyl boronic ester as a latent silicon nucleophile. The resulting C-silylated, unprotected (N-H) aziridines are obtained in high yields and with excellent enantioselectivities and can be further converted into valuable compounds with hardly any erosion of the enantiomeric excess.

Discrimination of the Enantiotopic Faces of Structurally Unbiased Carbenium Ions Employing a Cyclohexadiene-Based Chiral Hydride Source.

An enantioselective reduction of simple carbenium ions with cyclohexadienes containing a hydridic C-H bond at an asymmetrically substituted carbon atom is disclosed. The net reaction is a transfer hydrogenation of alkenes (styrenes) only employing chiral cyclohexadienes as dihydrogen surrogates. The trityl cation is used to initiate a Brønsted acid-promoted process, in which a delicate intermolecular capture of a carbenium-ion intermediate by the aforementioned chiral hydride source is enantioselectivity determining. Exclusively non-covalent interactions are rendering one of the transition states energetically more favored, giving the reduction products in good enantiomeric ratios. The computed reaction mechanism supports the present findings as well as previous results obtained from studies on other transfer-hydrogenation methods involving the cyclohexadiene platform.

Atroposelective Silylation of 1,1'-Biaryl-2,6-diols by a Chiral Counteranion Directed Desymmetrization Enhanced by a Subsequent Kinetic Resolution.

A desymmetrizing silylation of aromatic diols is reported. The previously unknown asymmetric silyl ether formation of phenol derivatives is achieved by applying List's counteranion directed silylation technique. A silylium-ion-like silicon electrophile generated from an allylic silane paired with an imidodiphosphorimidate (IDPi) enables enantioselective discrimination of achiral 1,1'-biaryl-2,6-diols. The enantioselectivity of that desymmetrization is further improved by a downstream kinetic resolution, converting the monosilylated minor enantiomer into the corresponding, again achiral bissilylated diol.

Perdeuteration of Deactivated Aryl Halides by H/D Exchange under Superelectrophile Catalysis.

Superelectrophilic silylium/arenium ions are shown to be highly effective H/D exchange promoters for the exhaustive deuteration of electron-deficient aryl halides. Several of the resulting perdeuterated aryl halides have been previously inaccessible with existing deuterium-labeling procedures. Using inexpensive C6D6 as the deuterium source, excellent degrees of deuterium incorporation were achieved under ambient reaction conditions. Importantly, the perdeuteration remains unaffected on multigram scale, even at a reduced catalyst loading of 0.1 mol %. By this method, otherwise expensive or noncommercially available NMR solvents such as 1,2-dichloro- and 1,2-difluorobenzene can be prepared.

Boosting the Enantioselectivity of Conjugate Borylation of α,ß-Disubstituted Cyclobutenones with Monooxides of Chiral C2 -Symmetric Bis(phosphine) Ligands.

Chiral bis(phosphine) monooxides (BPMOs) derived from C2 -symmetric bis(phosphines) have been found to induce superior levels of enantioselection in copper-catalyzed conjugate borylation of α,ß-disubstituted cyclobutenones. More precisely, enantiomeric excesses as well as chemical yields are exceedingly high with (R,R)-Bozphos as the chiral ligand while these values are low with parent (R,R)-Me-Duphos. A similar yet less pronounced effect was seen in the corresponding 1,6-addition to para-quinone methides.

Competition for Hydride Between Silicon and Boron: Synthesis and Characterization of a Hydroborane-Stabilized Silylium Ion.

Potent main-group Lewis acids are capable of activating element-hydrogen bonds. To probe the rivalry for hydride between silylium- and borenium-ion centers, a neutral precursor with the hydrosilane and hydroborane units in close proximity on a naphthalene-1,8-diyl platform was designed. Abstraction of one hydride leads to a hydroborane-stabilized silylium ion rather than a hydrosilane-coordinated borenium ion paired with [B(C6 F5 )4 ]- or [HCB11 Cl11 ]- as counteranions. Characterization by multinuclear NMR spectroscopy and X-ray diffraction supported by DFT calculations reveals a cationic, unsymmetrical open three-center, two-electron (3c2e) Si-H-B linkage.

Activation of the Si-B interelement bond related to catalysis.

Si-B reagents, namely silylboronic esters and silylboranes, have become increasingly attractive as versatile reagents to introduce silicon and boron atoms into organic frameworks. Diverse transformations through transition-metal-catalysed or transition-metal-free Si-B bond activation have become available. This Review summarises the recent developments in the now broad field of Si-B chemistry and covers the literature from the last seven years as an update of our review on the same topic published in early 2013 (M. Oestreich, E. Hartmann and M. Mewald, Chem. Rev., 2013, 113, 402-441). It mainly focuses on new applications of Si-B reagents but new methods of their preparation and, where relevant, reaction mechanisms are also discussed.

Decarbonylative Transfer Hydrochlorination of Alkenes and Alkynes Based on a B(C6 F5 )3 -Initiated Grob Fragmentation.

Readily available cyclohexa-2,5-dien-1-ylcarbonyl chloride derivatives are introduced as bench-stable HCl surrogates for transfer hydrochlorination of terminal and internal alkenes as well as selected alkynes. The stepwise Grob fragmentation of those acyl chlorides into chloride, carbon monoxide, a low-molecular-weight arene, and a proton is promoted by B(C6 F5 )3 . This decarbonylative transfer process enables the addition of HCl across C-C double and triple bonds with Markovnikov selectivity at room temperature.