1.
Bioorg Med Chem Lett
; 20(3): 918-21, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20044254
RESUMEN
Bridged monobactam beta-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C beta-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.