1.
Org Lett
; 22(15): 6187-6191, 2020 Aug 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32697586
RESUMEN
Transition-metal-catalyzed hydroalkylation of alkenes with 1,3-dicarbonyl compounds is a useful reaction to construct a C-C bond under neutral reaction conditions in a highly atom-economical manner. We found that hydroalkylation of aliphatic alkenes with ß-ketoesters proceeded with the use of a cationic iridium complex and bidentate phosphine ligand to give selectively branched α-substituted ß-ketoesters in high yields. The obtained hydroalkylated compounds can be converted to ß-substituted ketones through one-pot Krapcho dealkoxycarbonylation.