Separation of cellulose from industrial paper mill wastewater dried sludge using a commercial and cheap ionic liquid.

Industrial wastewaters and their treatment are now placed at the heart of the environmental concerns that industries face. Some research work has been carried out in order to limit the impact of these wastes on the environment as well as their costs. In this study, wastewater dehydrated sludge (55% wt. water content) from the paper industry was used to recover cellulose by using tetrakis(hydroxymethyl)phosphonium chloride, [P(CH2OH)4]Cl, ionic liquid as a solvent. The ionic liquid has shown remarkable results in terms of cellulose extraction in addition to its non-volatility and lower toxicity compared to organic volatile solvents. All cellulose, based on dry sludge, was recovered from the industrial dehydrated sludge with better operation conditions. The influence of temperature and the quantity of ionic liquid was preliminary studied in order to optimise the extraction conditions.

Exosomes-Promising Carriers for Regulatory Therapy in Oncology.

Extracellular vesicles (EVs), including exosomes and microvesicles, together with apoptotic bodies form a diverse group of nanoparticles that play a crucial role in intercellular communication, participate in numerous physiological and pathological processes. In the context of cancer, they can allow the transfer of bioactive molecules and genetic material between cancer cells and the surrounding stromal cells, thus promoting such processes as angiogenesis, metastasis, and immune evasion. In this article, we review recent advances in understanding how EVs, especially exosomes, influence tumor progression and modulation of the microenvironment. The key mechanisms include exosomes inducing the epithelial-mesenchymal transition, polarizing macrophages toward protumoral phenotypes, and suppressing antitumor immunity. The therapeutic potential of engineered exosomes is highlighted, including their loading with drugs, RNA therapeutics, or tumor antigens to alter the tumor microenvironment. Current techniques for their isolation, characterization, and engineering are discussed. Ongoing challenges include improving exosome loading efficiency, optimizing biodistribution, and enhancing selective cell targeting. Overall, exosomes present promising opportunities to understand tumorigenesis and develop more targeted diagnostic and therapeutic strategies by exploiting the natural intercellular communication networks in tumors. In the context of oncology, regulatory therapy provides the possibility of reproducing the original conditions that are unfavorable for the existence of the cancer process and may thus be a feasible alternative to population treatments. We also review current access to the technology enabling regulatory intervention in the cancer process using exosomes.

Scale-up and economic analysis of biodiesel production from municipal primary sewage sludge.

Municipal wastewater sludge is a promising lipid feedstock for biodiesel production, but the need to eliminate the high water content before lipid extraction is the main limitation for scaling up. This study evaluates the economic feasibility of biodiesel production directly from liquid primary sludge based on experimental data at laboratory scale. Computational tools were used for the modelling of the process scale-up and the different configurations of lipid extraction to optimise this step, as it is the most expensive. The operational variables with a major influence in the cost were the extraction time and the amount of solvent. The optimised extraction process had a break-even price of biodiesel of 1232 $/t, being economically competitive with the current cost of fossil diesel. The proposed biodiesel production process from waste sludge eliminates the expensive step of sludge drying, lowering the biodiesel price.