Detalles de la búsqueda
1.
Meeting report of the 3rd European Biotransformation Workshop.
Xenobiotica
; 53(2): 123-127, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36692101
2.
RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta-site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain.
J Labelled Comp Radiopharm
; 66(9): 222-236, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37095603
3.
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.
J Pharmacol Exp Ther
; 362(3): 413-423, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28642233
4.
In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.
Anal Chem
; 88(23): 11670-11677, 2016 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27934109
5.
Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo.
Drug Metab Dispos
; 44(4): 560-9, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26817949
6.
Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction - Liquid chromatography-tandem mass spectrometry.
Anal Biochem
; 498: 68-77, 2016 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26808647
7.
Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery.
Rapid Commun Mass Spectrom
; 30(2): 301-10, 2016 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-26689160
8.
Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.
Rapid Commun Mass Spectrom
; 28(24): 2695-703, 2014 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-25380491
9.
Metabolism and mass balance of SGLT2 inhibitor tofogliflozin following oral administration to humans.
Xenobiotica
; 44(4): 369-78, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24074237
10.
Software aided approaches to structure-based metabolite identification in drug discovery and development.
Drug Discov Today Technol
; 10(1): e207-17, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24050249
11.
A targeted proteomics approach to the identification of peptides modified by reactive metabolites.
Chem Res Toxicol
; 22(5): 853-62, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19317514
12.
Computational toxicology in drug development.
Drug Discov Today
; 13(7-8): 303-10, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18405842
13.
LC-MS/MS methods for the detection of isoprostanes (iPF2alpha-III and 8,12-iso-iPF2alpha-VI) as biomarkers of CCl4-induced oxidative damage to hepatic tissue.
J Chromatogr B Analyt Technol Biomed Life Sci
; 861(1): 48-55, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18160027
14.
Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.
J Pharm Biomed Anal
; 152: 143-154, 2018 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29414006
15.
Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design.
Drug Discov Today
; 22(5): 751-756, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27903430
16.
Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease.
Neurochem Int
; 48(8): 679-86, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16483694
17.
Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.
ACS Med Chem Lett
; 7(2): 192-7, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985297
18.
Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats.
Free Radic Biol Med
; 38(11): 1526-36, 2005 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15890627
19.
Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer.
J Am Soc Mass Spectrom
; 16(12): 1976-84, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16246572
20.
Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro.
Toxicol Lett
; 238(3): 53-9, 2015 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26256037