[Microbiota of lower urine tract and genital organs of healthy men and in infertility].

AIM: Study microflora of urine, ejaculate, urethra scrape in normal state and infertility. MATERIALS AND METHODS: 2 groups of men were examined: I (28)--control, conditionally healthy men (20 - 25 years of age), II (26)--infertile patients (25 - 35 years of age). Middle portion of morning urine, ejaculate, urethra scrape were studied in group I, in II--ejaculate. Bacteriologic study of urine and ejaculate was carried out in an extended kit of nutrient media (HiMedia) for facultative- anaerobic (FAB) and non-clostridia anaerobic bacteria (NAB). Urethra scrape and ejaculate were studied by PCR in group I. RESULTS: In urethra scrape and ejaculate a wide spectrum of FAB and NAB was detected in group I. Corynebacterium spp. and coagulase-negative staphylococci (67.9% each) were the dominant cluster of FAB. Eubacterium spp.--in NAB. Bacteriologic study of ejaculate corresponded in PCR with similar results of dominating bacteria. Among FAB the same clusters dominated during bacteriologic study of ejaculate from group II patients, among NAB--Propionibacterium spp., Peptococcus spp. and Peptostreptococcus spp. Quantitative characteristics of ejaculate of group I and II differed insignificantly. CONCLUSION: The frequency of detection of certain genera of FAB and NAB was significantly higher in patients with infertility than in conditionally healthy men, however quantitative parameters of the isolated microorganisms practically did not differ between groups.

[Non-clostridial anaerobic bacteria can cause acute pyelonephritis (an experimental trial)].

Acute obstructive pyelonephritis (PN) caused by Peptococcus niger (Pn), E. coli and mixed infection (Pn + E. coli) was modeled in rabbits. Morphologic examination showed that in animals with peptococcal infection renal lesions were identical to those in escherichial PN. Hemorrhagic infarctions and vasculitis develop in animals with mixed infection. These morphological findings were confirmed bacteriologically. The experimental trial confirms the role of Pn in development of acute obstructive PN in animals.

[Modern histological classification of renal neoplasms]. / Sovremennye predstavleniia o gistologicheskoi klassifikatsii raka pochki.

The review presents current literary information on basic forms of kidney cancer (clear cell carcinoma, chromophil or papillary cancer, chromophobe renal cell carcinoma, oncocytoma, Bellini carcinoma, sarcomatoid carcinoma and neuroendocrine carcinoma), their morphological characteristics and principles of classification. Modern histological classification of renal cancer is based on immunohistochemical evidence on markers of various nephron segments, this allowing to specify histogenesis of separate forms of renal cell carcinoma. In addition, cytogenetic studies of renal carcinoma reveal correlations between genetic changes in cancer cells and tumor phenotype found at light microscopy. Thus, current classification of renal carcinoma characterizes biology of these neoplasms. This should be taken into account in prognostication and design of new treatment methods.

[The morphological characteristics of endocrine-cell cancers of the large intestine]. / Morfologicheskie osobennosti éndokrinnokletochnykh rakov tolstoi kishki.

Histological variants of colon carcinoma depending upon the quantity of endocrine cells are distinguished on the basis of 66 malignant epithelial colon tumours morphological investigation. Special emphasis was made on the characteristics of the endocrine cell carcinoma, combined tumours with a combination of glandular and endocrine components, and amphicrin neoplasms. A trabecular-glandular variant of endocrine cell carcinoma is found to be predominant in the colon. The criteria are suggested for the identification of endocrine-cell tumours.

[Kidney carcinosarcoma]. / Kartsinosarkoma pochki.

A kidney tumour in a 36 year old female is described. The tumor was soft, of gray-brown color, size 12 x 11 cm. Histological, immunohistochemical and ultrastructural findings have demonstrated the signs of biphasic epithelial and mesenchymal cell differentiation. These data allowed the authors to define this tumor as a renal carcinosarcoma. Histogenesis of this tumor and differential diagnosis with other malignant renal tumors are discussed.