Búsqueda | BVS CLAP/SMR-OPS/OMS

1.

Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate.

Lagattuta, Kaitlyn A; Kang, Joyce B; Nathan, Aparna; Pauken, Kristen E; Jonsson, Anna Helena; Rao, Deepak A; Sharpe, Arlene H; Ishigaki, Kazuyoshi; Raychaudhuri, Soumya.

Nat Immunol ; 23(3): 446-457, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35177831

2.

Not-so-opposite ends of the spectrum: CD8⁺ T cell dysfunction across chronic infection, cancer and autoimmunity.

Collier, Jenna L; Weiss, Sarah A; Pauken, Kristen E; Sen, Debattama R; Sharpe, Arlene H.

Nat Immunol ; 22(7): 809-819, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-34140679

3.

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.

Benci, Joseph L; Xu, Bihui; Qiu, Yu; Wu, Tony J; Dada, Hannah; Twyman-Saint Victor, Christina; Cucolo, Lisa; Lee, David S M; Pauken, Kristen E; Huang, Alexander C; Gangadhar, Tara C; Amaravadi, Ravi K; Schuchter, Lynn M; Feldman, Michael D; Ishwaran, Hemant; Vonderheide, Robert H; Maity, Amit; Wherry, E John; Minn, Andy J.

Cell ; 167(6): 1540-1554.e12, 2016 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-27912061

4.

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1⁺ CD8⁺ T cells in tumor-draining lymph nodes.

Schenkel, Jason M; Herbst, Rebecca H; Canner, David; Li, Amy; Hillman, Michelle; Shanahan, Sean-Luc; Gibbons, Grace; Smith, Olivia C; Kim, Jonathan Y; Westcott, Peter; Hwang, William L; Freed-Pastor, William A; Eng, George; Cuoco, Michael S; Rogers, Patricia; Park, Jin K; Burger, Megan L; Rozenblatt-Rosen, Orit; Cong, Le; Pauken, Kristen E; Regev, Aviv; Jacks, Tyler.

Immunity ; 54(10): 2338-2353.e6, 2021 10 12.

Artículo en Inglés | MEDLINE | ID: mdl-34534439

5.

CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Kalekar, Lokesh A; Schmiel, Shirdi E; Nandiwada, Sarada L; Lam, Wing Y; Barsness, Laura O; Zhang, Na; Stritesky, Gretta L; Malhotra, Deepali; Pauken, Kristen E; Linehan, Jonathan L; O'Sullivan, M Gerard; Fife, Brian T; Hogquist, Kristin A; Jenkins, Marc K; Mueller, Daniel L.

Nat Immunol ; 17(3): 304-14, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26829766

6.

TCR-sequencing in cancer and autoimmunity: barcodes and beyond.

Pauken, Kristen E; Lagattuta, Kaitlyn A; Lu, Benjamin Y; Lucca, Liliana E; Daud, Adil I; Hafler, David A; Kluger, Harriet M; Raychaudhuri, Soumya; Sharpe, Arlene H.

Trends Immunol ; 43(3): 180-194, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35090787

7.

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.

Bengsch, Bertram; Johnson, Andy L; Kurachi, Makoto; Odorizzi, Pamela M; Pauken, Kristen E; Attanasio, John; Stelekati, Erietta; McLane, Laura M; Paley, Michael A; Delgoffe, Greg M; Wherry, E John.

Immunity ; 45(2): 358-73, 2016 08 16.

Artículo en Inglés | MEDLINE | ID: mdl-27496729

8.

SnapShot: T Cell Exhaustion.

Pauken, Kristen E; Wherry, E John.

Cell ; 163(4): 1038-1038.e1, 2015 Nov 05.

Artículo en Inglés | MEDLINE | ID: mdl-26544946

9.

Emerging concepts in PD-1 checkpoint biology.

Pauken, Kristen E; Torchia, James A; Chaudhri, Apoorvi; Sharpe, Arlene H; Freeman, Gordon J.

Semin Immunol ; 52: 101480, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-34006473

10.

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.

Huang, Alexander C; Postow, Michael A; Orlowski, Robert J; Mick, Rosemarie; Bengsch, Bertram; Manne, Sasikanth; Xu, Wei; Harmon, Shannon; Giles, Josephine R; Wenz, Brandon; Adamow, Matthew; Kuk, Deborah; Panageas, Katherine S; Carrera, Cristina; Wong, Phillip; Quagliarello, Felix; Wubbenhorst, Bradley; D'Andrea, Kurt; Pauken, Kristen E; Herati, Ramin S; Staupe, Ryan P; Schenkel, Jason M; McGettigan, Suzanne; Kothari, Shawn; George, Sangeeth M; Vonderheide, Robert H; Amaravadi, Ravi K; Karakousis, Giorgos C; Schuchter, Lynn M; Xu, Xiaowei; Nathanson, Katherine L; Wolchok, Jedd D; Gangadhar, Tara C; Wherry, E John.

Nature ; 545(7652): 60-65, 2017 05 04.

Artículo en Inglés | MEDLINE | ID: mdl-28397821

11.

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.

Chen, Ivy X; Newcomer, Kathleen; Pauken, Kristen E; Juneja, Vikram R; Naxerova, Kamila; Wu, Michelle W; Pinter, Matthias; Sen, Debattama R; Singer, Meromit; Sharpe, Arlene H; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 117(38): 23684-23694, 2020 09 22.

Artículo en Inglés | MEDLINE | ID: mdl-32907939

12.

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities.

Pauken, Kristen E; Dougan, Michael; Rose, Noel R; Lichtman, Andrew H; Sharpe, Arlene H.

Trends Immunol ; 40(6): 511-523, 2019 06.

Artículo en Inglés | MEDLINE | ID: mdl-31053497

13.

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

Fife, Brian T; Pauken, Kristen E; Eagar, Todd N; Obu, Takashi; Wu, Jenny; Tang, Qizhi; Azuma, Miyuki; Krummel, Matthew F; Bluestone, Jeffrey A.

Nat Immunol ; 10(11): 1185-92, 2009 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-19783989

14.

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.

Twyman-Saint Victor, Christina; Rech, Andrew J; Maity, Amit; Rengan, Ramesh; Pauken, Kristen E; Stelekati, Erietta; Benci, Joseph L; Xu, Bihui; Dada, Hannah; Odorizzi, Pamela M; Herati, Ramin S; Mansfield, Kathleen D; Patsch, Dana; Amaravadi, Ravi K; Schuchter, Lynn M; Ishwaran, Hemant; Mick, Rosemarie; Pryma, Daniel A; Xu, Xiaowei; Feldman, Michael D; Gangadhar, Tara C; Hahn, Stephen M; Wherry, E John; Vonderheide, Robert H; Minn, Andy J.

Nature ; 520(7547): 373-7, 2015 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-25754329

15.

Overcoming T cell exhaustion in infection and cancer.

Pauken, Kristen E; Wherry, E John.

Trends Immunol ; 36(4): 265-76, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25797516

16.

Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.

Manlove, Luke S; Schenkel, Jason M; Manlove, Kezia R; Pauken, Kristen E; Williams, Richard T; Vezys, Vaiva; Farrar, Michael A.

J Immunol ; 196(11): 4793-804, 2016 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-27183622

17.

IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.

Schenkel, Jason M; Fraser, Kathryn A; Casey, Kerry A; Beura, Lalit K; Pauken, Kristen E; Vezys, Vaiva; Masopust, David.

J Immunol ; 196(9): 3920-6, 2016 05 01.

Artículo en Inglés | MEDLINE | ID: mdl-27001957

18.

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

Gupta, Prakash K; Godec, Jernej; Wolski, David; Adland, Emily; Yates, Kathleen; Pauken, Kristen E; Cosgrove, Cormac; Ledderose, Carola; Junger, Wolfgang G; Robson, Simon C; Wherry, E John; Alter, Galit; Goulder, Philip J R; Klenerman, Paul; Sharpe, Arlene H; Lauer, Georg M; Haining, W Nicholas.

PLoS Pathog ; 11(10): e1005177, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26485519

19.

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.

Manlove, Luke S; Berquam-Vrieze, Katherine E; Pauken, Kristen E; Williams, Richard T; Jenkins, Marc K; Farrar, Michael A.

J Immunol ; 195(8): 4028-37, 2015 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-26378075

20.

Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.

Pauken, Kristen E; Nelson, Christine E; Martinov, Tijana; Spanier, Justin A; Heffernan, James R; Sahli, Nathanael L; Quarnstrom, Clare F; Osum, Kevin C; Schenkel, Jason M; Jenkins, Marc K; Blazar, Bruce R; Vezys, Vaiva; Fife, Brian T.

J Immunol ; 194(8): 3551-3555, 2015 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-25769925

BVS CLAP/SMR-OPS/OMS

Centro Latinoamericano de Perinatología, Salud de la Mujer y Reproductiva

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