Baron Dominique-Jean Larrey (1766-1842): innovator of the triage.

BACKGROUND: During times of war, it is common for some of the most valiant physicians to practice their skills at the battlefields. Only few of them, however, manage to excel. Among those physicians who seemed like the battlefield was their natural environment, was the military surgeon of the French army, Baron Dominique Jean Larrey (1766-1842). He studied medicine and served in the French Navy. Baron Larrey was one of the most significant medical innovators. METHODS: International literature was digitally searched. DISCUSSION: Larrey optimized a variety of procedures, even early neurosurgical ones. He also wrote medical treatises and most importantly invented the world famous 'flying ambulance'. During his 53-year service in the army he became the symbol of protection of the French warrior. That is why he was widely known as the 'protector of the soldier'. Nevertheless, his most eminent invention was the formation of the new 'triage' method. Due to Larrey's priceless impact in the domain of surgical innovation, a notable NATO award was created that is named after him. CONCLUSION: All references presented describe clearly Baron Larrey's contribution to medicine. His innovations in the sphere of the medical science renovated radically the medical ideas of his era.

Biomarkers in Cerebrospinal Fluid for the Diagnosis and Monitoring of Gliomas.

Gliomas are the most common type of malignant brain tumor and are characterized by a plethora of heterogeneous molecular alterations. Current treatments require the emergence of reliable biomarkers that will aid personalized treatment decisions and increase life expectancy. Glioma tissues are not as easily accessible as other solid tumors; therefore, detecting prominent biomarkers in biological fluids is necessary. Cerebrospinal fluid (CSF) circulates adjacent to the cerebral parenchyma and holds promise for discovering useful prognostic, diagnostic, and predictive biomarkers. In this review, we summarize extensive research regarding the role of circulating DNA, tumor cells, proteins, microRNAs, metabolites, and extracellular vesicles as potential CSF biomarkers for glioma diagnosis, prognosis, and monitoring. Future studies should address discrepancies and issues of specificity regarding CSF biomarkers, as well as the validation of candidate biomarkers.

Anatomical Variations of the Cystic Artery and Laparoscopic Cholecystectomy: A Persisting Surgical Challenge.

Although elective laparoscopic cholecystectomy is a common surgical procedure, it can become challenging due to multiple variants of the anatomy of both cystic artery and cystic bile duct. A 52-year-old male with a history of symptomatic cholelithiasis underwent elective laparoscopic cholecystectomy. During preparation of the Calot's triangle in order to achieve the "critical view of safety", an uncommon variation of the arterial anatomy was detected. The cystic artery was found to be originating from a robust middle hepatic artery instead of the right hepatic artery. The retrograde manner of cholecystectomy helped the visualization and protection of the middle hepatic artery. This anatomic finding was confirmed per CT done postoperatively. This case constitutes a rare arterial variation, in which the cystic artery arises from the middle hepatic artery, the artery that supplies the hepatic segment IV, which itself constituted a rare variation, since it arose from the anterior branch of the right hepatic artery. This artery could be falsely ligated instead of the real cystic artery. Certain techniques can be used to enhance the surgeon's ability to distinguish and safely ligate the proper entities. Anatomic knowledge of the possible variations of arterial and bile vessels is crucial for intraoperative recognition. Dissection of the Calot's triangle and reassurance of the "critical view of safety" are mandatory dissection techniques during laparoscopic cholecystectomy. Additionally, the retrograde manner of cholecystectomy can be of significant help in case of unclear anatomy in order to avoid ligation of uncertain entities during dissection.

Anatomy and Pathogenesis of Vascular Thoracic Outlet Syndrome.

The current literature review article describes the anatomy and pathogenesis of the vascular nature of thoracic outlet syndrome (TOS), as well as gathers the latest and most important information concerning its diagnostic methods and treatment. This syndrome's subcategory includes the venous and the arterial. Data for this review was accumulated through the PubMed database in which only scientific studies published in the last decade (2012-2022) were searched. PubMed offered 347 results, of which 23 were judged suitable and used. Non-invasive methods both for the diagnosis and the treatment of vascular TOS are gaining ground. Medicine, at this point, finds itself on the verge of slowly putting aside the previous invasive gold-standard methods, to be used only in the most urgent situations. The vascular thoracic outlet condition is a rare form of TOS but is also the most trouble-causing one and the deadliest. Fortunately, it can be more efficiently managed because of the current medical innovations. However, further research is needed to establish their already confirmed effectiveness, so they can be even more widely trusted and used.