RESUMEN
At the present time, whole body hyperthermia has been used to palliate disseminated disease in terminally ill patients, and to increase the quality of their lives by relieving tumour induced pain. Soft tissue sarcomas and tumours of gastro-intestinal origin may prove to be sensitive to hyperthermia. The future depends on finding individual tumour sensitivities and fractionating treatment more effectively.
Asunto(s)
Hipertermia Inducida , Neoplasias/terapia , Aire , Alanina Transaminasa/sangre , Anestesia , Antineoplásicos/uso terapéutico , Aspartato Aminotransferasas/sangre , Presión Sanguínea , Neoplasias de la Mama/terapia , Electrólitos/sangre , Femenino , Neoplasias Gastrointestinales/terapia , Frecuencia Cardíaca , Humanos , Hipertermia Inducida/efectos adversos , Hipertermia Inducida/métodos , Inmersión , L-Lactato Deshidrogenasa/sangre , Neoplasias Pulmonares/terapia , Masculino , Melanoma/terapia , Neoplasias/sangre , Neoplasias/fisiopatología , Parafina , Sarcoma/terapia , AguaRESUMEN
Fifty-one patients in the terminal stages of cancer have been treated with whole-body hyperthermia either alone (38 cases) or in combination with chemotherapy (13 cases). Altogether 227 treatment sessions were held averaging four hours each. The most sensitive tumours were those of the gastrointestinal tract and sarcomas. Breast and genitourinary tumours did not respond, and lung tumours and melanomas were only partially responsive. Major complications were remarkably few.
Asunto(s)
Hipertermia Inducida , Adulto , Temperatura Corporal , Neoplasias de la Mama/terapia , Niño , Neoplasias del Colon/terapia , Ciclofosfamida/uso terapéutico , Femenino , Fluorouracilo/uso terapéutico , Neoplasias Gastrointestinales/terapia , Humanos , Inyecciones Intravenosas , Masculino , Melfalán/uso terapéutico , Neoplasias/tratamiento farmacológico , Neoplasias/terapia , Factores de Tiempo , Vincristina/uso terapéuticoRESUMEN
The clinical and histological changes following hyperthermic perfusion of the distended urinary bladder have been studied in 13 patients with transitional cell carcinoma, persistent after radical radiotherapy. Continuous epidural anaesthesia was necessary to achieve a constant state of bladder relaxation during irrigation of the distended bladder. This form of hyperthermic perfusion of the bladder was effective in arresting uncontrollable haemorrhage from bladder tumours and may be of value in the treatment of this complication. Perfusion at an outflow temperature of 44 degrees C for 4 hours caused tumour necrosis. It was, however, associated with damage to the vasculature of the bladder and frequency of micturition which persisted after mucosal recovery. Perfusion at 43 degrees C also caused tumour necrosis and the after effects were less severe.