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1.
Rural Remote Health ; 22(1): 6887, 2022 02.
Artículo en Inglés | MEDLINE | ID: mdl-35138867

RESUMEN

INTRODUCTION: Children with deep-partial or full-thickness burns often require complicated post-surgical care and rehabilitation, including specialist occupational therapy (OT) intervention, to achieve optimal outcomes. Those from rural and remote areas rarely have access to these services and must travel to a tertiary referral hospital to access follow-up, placing them at higher risk of complications and poorer outcomes. The OT-Led Paediatric Burn Telehealth Review (OTPB) Clinic, based at Townsville University Hospital in northern Queensland, Australia, was set up to address this inequity. The aim of this study was to investigate the experience of both family members and clinicians in using the OTPB Clinic. METHODS: A qualitative approach, guided by interpretive phenomenology, was used. Eight family members and six clinicians participated in semi-structured interviews conducted by phone or telehealth. Thematic analysis was used to identify key themes. RESULTS: Four major themes were derived through thematic analysis: continuity of care, family-centred care, technology and building of rural capacity. CONCLUSION: Family and clinicians confirm benefits of a telehealth service for delivering care to rural and remote children after burn injury. The results show this expanded-scope, OT-led telehealth model provides quality patient-centred and expert clinical advice within local communities and builds the skill and capacity of local clinicians. Areas for service enhancement were uncovered. This telehealth model can be translated to other clinical subspecialties across Australia.


Asunto(s)
Quemaduras , Terapia Ocupacional , Servicios de Salud Rural , Telemedicina , Quemaduras/terapia , Cuidadores , Niño , Humanos , Población Rural , Telemedicina/métodos
2.
Rural Remote Health ; 21(3): 6223, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-34392690

RESUMEN

CONTEXT: Burns are a common injury in children. Rural and remote children with burn injuries are disadvantaged if their burns require hospitalisation and specialist rehabilitation. Most specialist burn rehabilitation is provided in regional or metropolitan cities by a multidisciplinary team. Therefore, rural and remote burn patients are required to travel to access these services. This project aimed to develop an Occupational Therapy (OT)-Led Paediatric Burn Telehealth Review Clinic (OTPB Clinic) at Townsville University Hospital (TUH) to provide ongoing rehabilitation to rural and remote children after burn injury closer to home. ISSUES: Local audits identified inequitable service delivery to children from rural and remote areas after burn injury. A project officer was appointed to develop the OTPB Clinic, including comprehensive guidelines to support sustainability. An expanded scope role was undertaken by the treating OT, and allied health assistants were engaged to promote efficient service delivery. LESSONS LEARNED: The OTPB Clinic commenced in 2017 and was evaluated using patient satisfaction surveys and number of clinical encounters pre- and post-implementation. During the implementation period, 28 rural or remote paediatric burn patients were reviewed. Review frequency increased from 20-week to 8-week intervals. Travel time was reduced by approximately 12 hours per appointment. Families identified numerous benefits of the clinic including continuity of care and reduced time away from work. Less than 4% of patients required re-engagement with paediatric surgeons for surgical intervention. The model has the potential to be transferred to other tertiary referral burns services.


Asunto(s)
Quemaduras , Telemedicina , Quemaduras/terapia , Niño , Hospitalización , Humanos , Derivación y Consulta , Población Rural
3.
BMC Psychiatry ; 20(1): 199, 2020 05 05.
Artículo en Inglés | MEDLINE | ID: mdl-32370778

RESUMEN

BACKGROUND: Patients with a diagnosis of schizophrenia are at an increased risk for developing metabolic syndrome, which is associated with greater cardiovascular morbidity and mortality. Treatment with some commonly used antipsychotic medications may increase the risk of developing metabolic syndrome. The aim of the study was to evaluate the safety of lurasidone in patients who continued lurasidone or switched from risperidone to lurasidone. A secondary aim was assessment of the effect of long-term lurasidone on the Positive and Negative Syndrome Scale (PANSS). METHODS: The treatment sample in the current study consisted of clinically stable patients with schizophrenia (N = 223) who had completed a 12-month, double-blind study of lurasidone vs. risperidone. In the current extension study, all patients received 6 months of open-label treatment with lurasidone, either continuing lurasidone assigned during the preceding double-blind trial, or switching from double-blind risperidone to lurasidone. Safety and tolerability parameters included body weight, prolactin, and metabolic laboratory tests. RESULTS: Six months of OL treatment with lurasidone was generally well-tolerated, with a low incidence of parkinsonism (4.5%) and akathisia (3.1%). Overall, few adverse events were rated as severe (4.9%), and discontinuation due to an adverse event was low in the lurasidone continuation vs. risperidone switch groups (3.7% vs. 6.9%). In the lurasidone continuation versus risperidone switch groups, change from OL baseline to 6-month endpoint (observed case) was observed in mean body weight (- 0.6 vs. -2.6 kg), median total cholesterol (- 4.0 vs. + 4.5 mg/dL), triglycerides (- 4.5 vs. -5.5 mg/dL), glucose (0.0 vs. -3.0 mg/dL) and prolactin (males, + 0.15 vs. -11.2 ng/mL; females, + 1.3 vs. -30.8 ng/mL). Improvement in PANSS total score was maintained, from OL baseline to endpoint in the continuation vs. switch groups (+ 1.0 vs. -1.0; OC). CONCLUSIONS: In this 6-month extension study, lurasidone treatment was generally well-tolerated and associated with minimal effects on weight, metabolic parameters, and prolactin levels. Patients who switched from risperidone to lurasidone experienced reductions in weight, metabolic parameters and prolactin levels commensurate with increases in these safety parameters experienced during the previous 12 months of treatment with risperidone. TRIAL REGISTRATION: ClinicalTrials.gov NCT00641745 (Date of Registration: March 24, 2008).


Asunto(s)
Clorhidrato de Lurasidona/administración & dosificación , Clorhidrato de Lurasidona/uso terapéutico , Síndrome Metabólico/inducido químicamente , Risperidona/administración & dosificación , Risperidona/uso terapéutico , Esquizofrenia/complicaciones , Esquizofrenia/tratamiento farmacológico , Adulto , Antipsicóticos/administración & dosificación , Antipsicóticos/uso terapéutico , Método Doble Ciego , Femenino , Humanos , Masculino , Síndrome Metabólico/complicaciones , Factores de Tiempo , Resultado del Tratamiento
4.
J Environ Sci (China) ; 85: 156-167, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31471022

RESUMEN

This study evaluated uranium sequestration performance in iron-rich (30 g/kg) sediment via bioreduction followed by reoxidation. Field tests (1383 days) at Oak Ridge, Tennessee demonstrated that uranium contents in sediments increased after bioreduced sediments were re-exposed to nitrate and oxygen in contaminated groundwater. Bioreduction of contaminated sediments (1200 mg/kg U) with ethanol in microcosm reduced aqueous U from 0.37 to 0.023 mg/L. Aliquots of the bioreduced sediment were reoxidized with O2, H2O2, and NaNO3, respectively, over 285 days, resulting in aqueous U of 0.024, 1.58 and 14.4 mg/L at pH 6.30, 6.63 and 7.62, respectively. The source- and the three reoxidized sediments showed different desorption and adsorption behaviors of U, but all fit a Freundlich model. The adsorption capacities increased sharply at pH 4.5 to 5.5, plateaued at pH 5.5 to 7.0, then decreased sharply as pH increased from 7.0 to 8.0. The O2-reoxidized sediment retained a lower desorption efficiency at pH over 6.0. The NO3--reoxidized sediment exhibited higher adsorption capacity at pH 5.5 to 6.0. The pH-dependent adsorption onto Fe(III) oxides and formation of U coated particles and precipitates resulted in U sequestration, and bioreduction followed by reoxidation can enhance the U sequestration in sediment.


Asunto(s)
Biodegradación Ambiental , Contaminantes Radiactivos del Suelo/metabolismo , Uranio/metabolismo , Sedimentos Geológicos/química , Contaminantes Radiactivos del Suelo/química , Tennessee , Uranio/química
5.
J Environ Manage ; 215: 132-142, 2018 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-29567553

RESUMEN

The objective of the study was to carry-out batch tests to examine the effectiveness of Haix-Fe-Zr and Haix-Zr resin beads in the removal of As(III), As(V) and F- from groundwater with a similar geochemistry to a site where a community-based drinking water plant has been installed in West Bengal, India. The groundwater was spiked separately with ∼200 µg/L As(III) and As(V) and 5 mg/L F-. Haix-Zr resin beads were more effective than Haix-Fe-Zr resin beads in removing As(III) and As(V). Haix-Zr resin beads showed higher removal of As(V) compared to As(III). Haix-Zr resin beads removed As(V) below the WHO (10 µg/L) drinking water standards at 8.79 µg/L after 4 h of shaking, while As(III) was reduced to 7.72 µg/L after 8 h of shaking. Haix-Fe-Zr resin beads were more effective in removing F- from the spiked groundwater compared to Haix-Zr resin beads. Concentrations of F- decreased from 6.27 mg/L to 1.26 mg/L, which is below the WHO drinking water standards (1.5 mg/L) for F-, after 15 min of shaking with Haix-Fe-Zr resin beads. After 20 min of shaking in groundwater treated with Haix-Zr resin beads, F- concentrations decreased from 6.27 mg/L to 1.43 mg/L. In the removal of As(III), As(V), and F- from the groundwater, Haix-Fe-Zr and Haix-Zr resin beads fit the parabolic diffusion equation (PDE) suggesting that adsorption of these contaminants was consistent with inter-particle diffusion.


Asunto(s)
Arsénico/aislamiento & purificación , Agua Potable , Fluoruros/aislamiento & purificación , Purificación del Agua , Adsorción , Agua Subterránea , India , Contaminantes Químicos del Agua
6.
Environ Sci Technol ; 49(20): 12105-11, 2015 Oct 20.
Artículo en Inglés | MEDLINE | ID: mdl-26389816

RESUMEN

The impact of mercury (Hg) on human and ecological health has been known for decades. Although a treaty signed in 2013 by 147 nations regulates future large-scale mercury emissions, legacy Hg contamination exists worldwide and small-scale releases will continue. The fate of elemental mercury, Hg(0), lost to the subsurface and its potential chemical transformation that can lead to changes in speciation and mobility are poorly understood. Here, we show that Hg(0) beads interact with soil or manganese oxide solids and X-ray spectroscopic analysis indicates that the soluble mercury coatings are HgO. Dissolution studies show that, after reacting with a composite soil, >20 times more Hg is released into water from the coated beads than from a pure liquid mercury bead. An even larger, >700 times, release occurs from coated Hg(0) beads that have been reacted with manganese oxide, suggesting that manganese oxides are involved in the transformation of the Hg(0) beads and creation of the soluble mercury coatings. Although the coatings may inhibit Hg(0) evaporation, the high solubility of the coatings can enhance Hg(II) migration away from the Hg(0)-spill site and result in potential changes in mercury speciation in the soil and increased mercury mobility.


Asunto(s)
Compuestos de Mercurio/química , Mercurio/química , Óxidos/química , Contaminantes del Suelo/química , Compuestos de Manganeso/química , Mercurio/análisis , Suelo/química , Contaminantes del Suelo/análisis , Solubilidad , Agua/química , Espectroscopía de Absorción de Rayos X
7.
Water Environ Res ; 87(8): 751-7, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-26237691

RESUMEN

The advancement of telemetry control for the water industry has increased the difficulty of managing large volumes of nuisance alarms (i.e., alarms that do not require a response). The aim of this study was to identify and reduce the number of nuisance alarms that occur for Northern Ireland (NI) Water by carrying out alarm duration analysis to determine the appropriate length of persistence (an advanced alarm management tool) that could be applied. All data were extracted from TelemWeb (NI Water's telemetry monitoring system) and analyzed in Excel. Over a 6-week period, an average of 40 000 alarms occurred per week. The alarm duration analysis, which has never been implemented before by NI Water, found that an average of 57% of NI Water alarms had a duration of <5 minutes. Applying 5-minute persistence, therefore, could prevent an average 26 816 nuisance alarms per week. Most of these alarms were from wastewater assets.


Asunto(s)
Industrias , Administración de Residuos/métodos , Agua , Irlanda del Norte , Control de Calidad , Riesgo , Estaciones del Año , Factores de Tiempo
8.
Wound Manag Prev ; 67(11): 12-25, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-35030094

RESUMEN

BACKGROUND: Turning nursing home residents every 2 hours has been a long-held standard for pressure injury (PrI) prevention in individuals with mobility impairments although evidence to substantiate this practice is limited. New guidelines recommend personalizing turning schedules to support person-centered care but lack specific recommendations about which turning frequencies are appropriate for various risk levels. PURPOSE: This quality improvement program aimed to determine the feasibility and outcomes of using individualized turn schedules for newly admitted nursing home residents. METHODS: An expert panel of wound clinicians developed, tested, and implemented a turn frequency tool that allowed staff in 2 nursing homes to select a turning schedule of 1, 2, 3, or 4 hours based on resident risk factors. Turning schedules were operationalized using a wearable sensor-based visual cueing technology that alerted staff to resident repositioning needs. Nonparticipating resident data were collected for comparison of PrI incidence. Descriptive statistics were calculated for all covariates. Significance of differences tests were performed as appropriate. RESULTS: Over 7 months, 154 residents had their turn period individualized, with 56% qualifying for 3-hour (Q3H) or 4-hour (Q4H) schedules. Facility-acquired PrI incidence was 94% lower in participants than in nonparticipants (P < .0001). Use of 3-hour and 4-hour intervals saved roughly 21 and 35 minutes of staff time, respectively, per resident per shift. CONCLUSION: Individualizing turning schedules is feasible. Residents with longer turning intervals did not develop PrIs, supporting previous studies about safely extending turning periods for most residents.


Asunto(s)
Úlcera por Presión , Mejoramiento de la Calidad , Humanos , Incidencia , Casas de Salud , Úlcera por Presión/epidemiología , Úlcera por Presión/prevención & control , Tecnología
9.
Environ Monit Assess ; 160(1-4): 101-21, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-19130278

RESUMEN

Accelerated soil erosion is an aspect of dryland degradation that is affected by repeated intense drought events and land management activities such as commercial livestock grazing. A soil stability index (SSI) that detects the erosion status and susceptibility of a landscape at the pixel level, i.e., stable, erosional, or depositional pixels, was derived from the spectral properties of an archived time series (from 1972 to 1997) of Landsat satellite data of a commercial ranch in northeastern Utah. The SSI was retrospectively validated with contemporary field measures of soil organic matter and erosion status that was surveyed by US federal land management agencies. Catastrophe theory provided the conceptual framework for retrospective assessment of the impact of commercial grazing and soil water availability on the SSI. The overall SSI trend was from an eroding landscape in the early drier 1970s towards stable conditions in the wetter mid-1980s and late 1990s. The landscape catastrophically shifted towards an extreme eroding state that was coincident with the "The Great North American Drought of 1988". Periods of landscape stability and trajectories toward stability were coincident with extremely wet El Niño events. Commercial grazing had less correlation with soil stability than drought conditions. However, the landscape became more susceptible to erosion events under multiple droughts and grazing. Land managers now have nearly a year warning of El Niño and La Niña events and can adjust their management decisions according to predicted landscape erosion conditions.


Asunto(s)
Cambio Climático , Ecosistema , Monitoreo del Ambiente , Suelo/análisis , Animales , Conservación de los Recursos Naturales , Conducta Alimentaria
10.
J Cardiothorac Surg ; 15(1): 91, 2020 May 12.
Artículo en Inglés | MEDLINE | ID: mdl-32398105

RESUMEN

BACKGROUND: Thoracic surgeons have been incorporating enhanced recovery after surgery (ERAS) protocols into their practices, not only to reduce narcotic usage but also to improve complication rates and decrease lengths of stay. Here, we describe the utility of a regional block technique that can be used for patients undergoing urgent or elective thoracic surgical procedures or suffering from rib fractures. METHODS: We report our initial one-year experience with these erector spinae plane (ESP) blocks. RESULTS: ESP blocks were placed in 42 patients. The procedure was performed by a trained team of anesthesiologists and certified nurse practitioners. It included placement of a catheter on the ipsilateral chest, followed by a 20 ml of 0.2% ropivacaine bolus and continuous infusion. Patients were then followed by the regional team, as long as the catheter was in place. While it had some technical challenges, the block was effective in 83.3% of patients with no reported mortality or major complications. However, given the confounding factors of the study (such as simultaneous implementation of ERAS protocol) and heterogeneity of the patient population, a control group was difficult to ascertain and meaningful opioid consumption analysis was difficult to perform. CONCLUSIONS: Regional blocks, such as the ESP block, complement fundamental ERAS principles and serve as an adjunct to the available armamentarium for non-narcotic ways to control pain in thoracic surgical and chest trauma patients. Continued collaboration between the thoracic surgeons and anesthesiologists is needed for its success.


Asunto(s)
Anestésicos Locales , Dolor Musculoesquelético/terapia , Bloqueo Nervioso/métodos , Manejo del Dolor/métodos , Músculos Paraespinales , Ropivacaína , Adulto , Anciano , Anciano de 80 o más Años , Recuperación Mejorada Después de la Cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dolor Musculoesquelético/etiología , Fracturas de las Costillas/complicaciones , Procedimientos Quirúrgicos Torácicos , Tórax
11.
Chemosphere ; 212: 262-271, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30145418

RESUMEN

Academics researchers and "citizen scientists" from 22 countries confirmed that yellow mealworms, the larvae of Tenebrio molitor Linnaeus, can survive by eating polystyrene (PS) foam. More detailed assessments of this capability for mealworms were carried out by12 sources: five from the USA, six from China, and one from Northern Ireland. All of these mealworms digested PS foam. PS mass decreased and depolymerization was observed, with appearance of lower molecular weight residuals and functional groups indicative of oxidative transformations in extracts from the frass (insect excrement). An addition of gentamycin (30 mg g-1), a bactericidal antibiotic, inhibited depolymerization, implicating the gut microbiome in the biodegradation process. Microbial community analyses demonstrated significant taxonomic shifts for mealworms fed diets of PS plus bran and PS alone. The results indicate that mealworms from diverse locations eat and metabolize PS and support the hypothesis that this capacity is independent of the geographic origin of the mealworms, and is likely ubiquitous to members of this species.


Asunto(s)
Bacterias/metabolismo , Biodegradación Ambiental , Escarabajos/metabolismo , Microbioma Gastrointestinal/fisiología , Larva/metabolismo , Poliestirenos/metabolismo , Animales , Antibacterianos/farmacología , Bacterias/efectos de los fármacos , China , Escarabajos/crecimiento & desarrollo , Microbioma Gastrointestinal/efectos de los fármacos , Gentamicinas/farmacología , Larva/crecimiento & desarrollo
12.
Ann Pharmacother ; 41(1): 153-6, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17164393

RESUMEN

OBJECTIVE: To report a case of perioral numbness associated with intravenous pentamidine. CASE SUMMARY: A 56-year-old female with acute myelogenous leukemia in remission developed Pneumocystis carinii infection. Treatment was initiated with trimethoprim/sulfamethoxazole (TMP/SMX), but the patient subsequently developed a rash on day 10 of treatment. TMP/SMX was discontinued and intravenous pentamidine was started in order to complete a 21 day treatment course for P. carinii pneumonia (PCP). However, on day 3 of pentamidine treatment, the patient reported perioral numbness during the infusion. The numbness disappeared soon after completion of the infusion but recurred with all subsequent pentamidine infusions. DISCUSSION: Paresthesias in general and facial area numbness in particular have been reported with pentamidine administration. While it is possible such adverse events may be a result of pentamidine's effect on serum electrolytes and glucose, especially hypocalcemia and hypoglycemia, these laboratory values were not grossly affected by pentamidine in our patient. The Naranjo probability scale revealed a probable adverse reaction of perioral numbness associated with intravenous pentamidine. CONCLUSIONS: Pentamidine is considered an alternative agent to TMP/SMX in the treatment of PCP. Although they do not commonly occur, paresthesias have been reported with pentamidine therapy. Healthcare practitioners should be aware of this type of event in association with pentamidine administration, especially as it may not be associated with overt serum glucose or electrolyte disturbances.


Asunto(s)
Hipoestesia/inducido químicamente , Enfermedades de la Boca/inducido químicamente , Pentamidina/administración & dosificación , Pentamidina/efectos adversos , Femenino , Humanos , Hipoestesia/diagnóstico , Infusiones Intravenosas , Persona de Mediana Edad , Enfermedades de la Boca/diagnóstico
13.
J Am Acad Child Adolesc Psychiatry ; 56(12): 1015-1025, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29173735

RESUMEN

OBJECTIVE: To evaluate the efficacy and safety of lurasidone in children and adolescents with bipolar depression. METHOD: Patients 10 to 17 years old with a DSM-5 diagnosis of bipolar I depression were randomized to 6 weeks of double-blind treatment with flexible doses of lurasidone 20 to 80 mg/day. The primary endpoint was change from baseline to week 6 in the Children's Depression Rating Scale-Revised (CDRS-R) total score, evaluated by a mixed-model repeated-measures analysis. RESULTS: A total of 347 patients were randomized and received at least 1 dose of lurasidone (n = 175; mean age 14.2 years; mean dose 33.6 mg/day) or placebo (n = 172; mean age 14.3 years). At week 6, treatment with lurasidone was associated with statistically significant improvement compared with placebo in CDRS-R total score (-21.0 versus -15.3; p < .0001; effect size 0.45). Lurasidone also was associated with statistically significant improvement in the Clinical Global Impression-Bipolar Severity depression score (key secondary measure) and in measures of anxiety, quality of life, and global functioning. Study completion rates were 92.0% in the lurasidone group and 89.7% in the placebo group; discontinuation rates due to adverse events were the same for the 2 groups (1.7%). The 2 most common adverse events on lurasidone were nausea and somnolence. Treatment with lurasidone was associated with few effects on weight and metabolic parameters. CONCLUSION: In this placebo-controlled study, monotherapy with lurasidone, in the dose range of 20 to 80 mg/day, significantly decreased depressive symptoms in children and adolescents with bipolar depression. Lurasidone was well tolerated, with minimal effects on weight and metabolic parameters. Clinical trial registration information-Lurasidone Pediatric Bipolar Study; http://Clinicaltrials.gov; NCT02046369.


Asunto(s)
Antipsicóticos/uso terapéutico , Trastorno Bipolar/tratamiento farmacológico , Clorhidrato de Lurasidona/uso terapéutico , Adolescente , Trastorno Bipolar/diagnóstico , Niño , Método Doble Ciego , Esquema de Medicación , Femenino , Humanos , Masculino , Escalas de Valoración Psiquiátrica , Resultado del Tratamiento
14.
J Environ Qual ; 35(5): 1731-41, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16899744

RESUMEN

Site characterization is an essential initial step in determining the feasibility of remedial alternatives at hazardous waste sites. Physicochemical and mineralogical characterization of U-contaminated soils in deeply weathered saprolite at Area 2 of the DOE Field Research Center (FRC) site, Oak Ridge, TN, was accomplished to examine the feasibility of bioremediation. Concentrations of U in soil-saprolite (up to 291 mg kg(-1) in oxalate-extractable U(o)) were closely related to low pH (ca. 4-5), high effective cation exchange capacity without Ca (64.7-83.2 cmol(c) kg(-1)), amorphous Mn content (up to 9910 mg kg(-1)), and the decreased presence of relative clay mineral contents in the bulk samples (i.e., illite 2.5-12 wt. %, average 32 wt. %). The pH of the fill material ranged from 7.0 to 10.5, whereas the pH of the saprolite ranged from 4.5 to 8. Uranium concentration was highest (about 300 mg kg(-1)) at around 6 m below land surface near the saprolite-fill interface. The pH of ground water at Area 2 tended to be between 6 and 7 with U concentrations of about 0.9 to 1.7 mg L(-1). These site specific characteristics of Area 2, which has lower U and nitrate contamination levels and more neutral ground water pH compared with FRC Areas 1 and 3 (ca. 5.5 and <4, respectively), indicate that with appropriate addition of electron donors and nutrients bioremediation of U by metal reducing microorganisms may be possible.


Asunto(s)
Monitoreo del Ambiente , Microbiología del Suelo , Contaminantes Radiactivos del Suelo/análisis , Suelo/análisis , Uranio/análisis , Contaminantes Radiactivos del Agua/análisis , Biodegradación Ambiental/efectos de la radiación , Calcio/análisis , Calcio/química , Monitoreo del Ambiente/métodos , Estudios de Evaluación como Asunto , Manganeso/análisis , Manganeso/química , Contaminantes Radiactivos del Suelo/química , Contaminantes Radiactivos del Suelo/metabolismo , Tennessee , Uranio/química , Uranio/metabolismo , Contaminantes Radiactivos del Agua/química , Contaminantes Radiactivos del Agua/farmacología
15.
J Med Pract Manage ; 21(4): 219-24, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16562525

RESUMEN

A major challenge for healthcare in the United States is recruiting and retaining health professionals in rural areas of the country. There is a significant shortage of physicians and other health professionals in many of these areas. This article outlines some of the factors that go into recruiting health professionals to practice in rural communities, and what factors are influential in making sure they remain in service to those communities.


Asunto(s)
Fuerza Laboral en Salud , Lealtad del Personal , Selección de Personal , Servicios de Salud Rural , Humanos , Estados Unidos
17.
J Psychopharmacol ; 30(1): 69-77, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26645209

RESUMEN

OBJECTIVE: To evaluate the effectiveness of lurasidone as maintenance treatment for schizophrenia. METHOD: Adults experiencing an acute exacerbation of schizophrenia initially received 12-24 weeks of open-label treatment with lurasidone (40-80 mg/d, flexibly dosed). Patients who maintained clinical stability for ⩾12 weeks were randomized in double-blind fashion to placebo or lurasidone (40-80 mg/d, flexibly dosed) for an additional 28-week treatment period. The primary efficacy endpoint was time to relapse (based on Kaplan-Meier survival analysis). RESULTS: A total of 676 patients enrolled in the open-label phase; 285 met protocol-specified stabilization criteria and were randomized to lurasidone (N=144) or placebo (N=141). During the open-label phase, mean Positive and Negative Syndrome Scale total score decreased from 90.1 to 54.4 in patients who met clinical stability criteria and were randomized. In the double-blind phase, lurasidone significantly delayed time to relapse compared with placebo (log-rank test, p=0.039), reflecting a 33.7% reduction in risk of relapse (Cox hazard ratio (95% confidence interval), 0.663 (0.447-0.983); p=0.041). Probability of relapse at the double-blind week 28 endpoint (based on Kaplan-Meier analysis) was 42.2% in the lurasidone group and 51.2% in the placebo group. Minimal changes in weight, lipid, glucose, and prolactin were observed throughout the study. CONCLUSIONS: This multicenter, placebo-controlled, randomized withdrawal study demonstrated the efficacy of lurasidone for the maintenance treatment of patients with schizophrenia.


Asunto(s)
Antipsicóticos/administración & dosificación , Clorhidrato de Lurasidona/administración & dosificación , Esquizofrenia/tratamiento farmacológico , Adulto , Antipsicóticos/uso terapéutico , Método Doble Ciego , Femenino , Humanos , Clorhidrato de Lurasidona/uso terapéutico , Masculino , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Escalas de Valoración Psiquiátrica , Recurrencia , Esquizofrenia/fisiopatología , Factores de Tiempo , Resultado del Tratamiento
18.
BMC Microbiol ; 4: 3, 2004 Jan 14.
Artículo en Inglés | MEDLINE | ID: mdl-14720306

RESUMEN

BACKGROUND: Sucrose density gradient centrifugation and cross-flow filtration methods have been developed and standardised for the safe and reproducible production of inactivated arbovirus antigens which are appropriate for use in diagnostic serological applications. METHODS: To optimise the maximum titre of growth during the propagation of arboviruses, the multiplicity of infection and choice of cell line were investigated using stocks of Ross River virus and Barmah Forest virus grown in both mosquito and mammalian cell lines. To standardise and improve the efficacy of the inactivation of arboviral suspensions, stocks of Ross River virus, Barmah Forest virus, Japanese encephalitis virus, Murray Valley encephalitis virus and Alfuy virus were chemically inactivated using binary ethylenimine at a final concentration of 3 mM. Aliquots were then taken at hourly intervals and crude inactivation rates were determined for each virus using a plaque assay. To ensure complete inactivation, the same aliquots were each passaged 3 times in Aedes albopictus C6/36 cells and the presence of viral growth was detected using an immunofluorescent assay. For larger quantities of viral suspensions, centrifugation on an isopycnic sucrose density gradient or cross-flow filtration was used to produce concentrated, pure antigens or partially concentrated, semi-purified antigens respectively. RESULTS: The results of the propagation experiments suggested that the maximum viral titres obtained for both Ross River virus and Barmah Forest virus were affected by the incubation period and choice of cell line, rather than the use of different multiplicity of infection values. Results of the binary ethylenimine inactivation trial suggested that standardised periods of 5 or 8 hours would be suitable to ensure effective and complete inactivation for a number of different arboviral antigens. CONCLUSION: Two methods used to prepare inactivated arbovirus antigens have been standardised to minimise production failure and expenditure and to provide reagents that conform to the highest quality and safety requirements of a diagnostic serology laboratory. The antigens are suitable for use in either enzyme linked immunosorbent assays or haemagglutination inhibition assays and the optimised protocols can be directly applied to produce antigens from new or emerging arboviral pathogens.


Asunto(s)
Antígenos Virales/metabolismo , Arbovirus/fisiología , Aziridinas/farmacología , Inactivación de Virus , Aedes/citología , Alphavirus/fisiología , Animales , Antígenos Virales/aislamiento & purificación , Arbovirus/efectos de los fármacos , Línea Celular , Centrifugación por Gradiente de Densidad , Virus de la Encefalitis Japonesa (Especie)/fisiología , Filtración , Virus del Río Ross/fisiología , Replicación Viral
19.
J Rural Health ; 18 Suppl: 211-32, 2002.
Artículo en Inglés | MEDLINE | ID: mdl-12061515

RESUMEN

One of the most recalcitrant problems of the rural health landscape is the uneven distribution and relative shortage of medical care providers. Despite considerable efforts by federal and state governments over the past three decades to address these problems, rural provider distribution and shortage issues have persisted. The purpose of this article is to identify the challenges for rural health research and policy regarding health provider supply in the first decade of the 21st century. While the emphasis in this article is on physicians, workforce concerns pertaining to nurses, nurse practitioners, and physician assistants are briefly described. Physician supply, geographic and specialty distribution, age, gender, quality of care, recruitment and retention, training, productivity and income, reimbursement and managed care, federal and state ameliorative programs, safety net, and telehealth are discussed. Also highlighted are issues concerning rural health care workforce research, methods, and data as well as a series of policy-relevant questions. Solutions to rural health personnel problems can only be successfully addressed through multifaceted approaches. No vision of the future of rural health can come to fruition if it does not promote stable, rewarding, and fulfilling professional and personal lives for rural health care providers.


Asunto(s)
Fuerza Laboral en Salud/estadística & datos numéricos , Ubicación de la Práctica Profesional/estadística & datos numéricos , Servicios de Salud Rural , Adulto , Técnicos Medios en Salud/economía , Técnicos Medios en Salud/provisión & distribución , Odontólogos/economía , Odontólogos/provisión & distribución , Femenino , Encuestas de Atención de la Salud , Política de Salud , Necesidades y Demandas de Servicios de Salud/estadística & datos numéricos , Fuerza Laboral en Salud/economía , Humanos , Masculino , Persona de Mediana Edad , Enfermeras y Enfermeros/economía , Enfermeras y Enfermeros/provisión & distribución , Selección de Personal , Médicos/economía , Médicos/provisión & distribución , Calidad de la Atención de Salud , Servicios de Salud Rural/estadística & datos numéricos , Estados Unidos
20.
Fam Med ; 34(3): 183-9, 2002 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11922533

RESUMEN

BACKGROUND AND OBJECTIVES: Recent recommendations requiring resident training in community-oriented primary care (COPC) indicate a continued interest among family medicine educators. This study examines COPC-related aspects of training and practice and whether or not respondents report COPC knowledge. The study also compares residency program and physician responses. METHODS: A total of 400 randomly selected practicing physicians and 470 residency directors were asked about COPC curricular and practice experiences. Physicians were asked if they practice COPC. Programs were asked if they taught COPC. Both were asked if they were knowledgeable about COPC. RESULTS: Response rates for practicing physicians and programs were 58.4% and 71.8%, respectively; 38.8% of programs teach COPC, and 6.7% of physicians reported that they practice COPC. Sixty-seven percent of programs and 19% of physicians reported COPC knowledge. Programs with knowledge of COPC conducted more COPC-related activities than those without such knowledge. This relationship was not seen among practicing physicians. CONCLUSIONS: Aspects of COPC exist in training and in practice environments. Knowledge about COPC is associated with differences in programs' COPC activities but not in the COPC activities of practicing physicians. Programs and physicians differ in COPC implementation in training and practice.


Asunto(s)
Medicina Comunitaria/educación , Medicina Familiar y Comunitaria/educación , Conocimientos, Actitudes y Práctica en Salud , Internado y Residencia/estadística & datos numéricos , Atención Primaria de Salud/organización & administración , Competencia Clínica , Curriculum , Encuestas de Atención de la Salud , Humanos , Internado y Residencia/normas , Encuestas y Cuestionarios , Estados Unidos
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