Immunoblastic morphology in diffuse large B-cell lymphoma is associated with a nongerminal center immunophenotypic profile.

Diffuse large B cell lymphomas (DLCBL) are a group of lymphomas whose biologic and prognostic diversity has been recently well characterized. There is also morphologic heterogeneity, but the relevance of subclassification remains uncertain. The World Health Organization Classification states that pathologists have the choice to use only the term diffuse large B-cell lymphoma or to use one of the specific morphologic variants. The aim of the present study was to evaluate if there is an association between immunoblastic morphology and the immunophenotypic profile in DLBCL. Two observers reviewed 117 DLBCL cases. Cases of immunoblastic lymphoma and cases of centroblastic polymorphic lymphoma with more than 50% immunoblasts were defined as having immunoblastic morphology. Immunohistochemistry was performed on tissue microarray slides to establish the immunophenotypic profile. Patients with immunoblastic morphology more frequently had a non-GCB phenotype (94% vs 6%). This finding suggests that the morphological subclassification of DLBCL does have biological meaning, in line with recent evidence indicating that the immunoblastic morphology should not be overlooked in lymphoma classification.

Percepção de vulnerabilidade ao HPV e câncer de cabeça e pescoço: comportamentos sexuais e de risc oem jovens de Niterói, RJ / Perception of vulnerability to HPV and head and neck cancer: sexual and risk behaviors in youths from Niteroi, RJ

A associação do papilomavírus humano (HPV) ao carcinoma de células escamosas em região de cabeça e pescoço representa um problema de saúde pública, em especial para os jovens que são mais sujeitos às doenças sexualmente transmissíveis (DST). Objetivo: avaliar a vulnerabilidade à transmissão do HPV e ao câncer de cabeça e pescoço em população jovem do município de Niterói. Métodos: um estudo exploratório descritivo foiconduzido por meio de questionários com 450 participantes. Os dados obtidos foram divididos em características sociodemográficas, comportamento sexual, fatores de risco para o câncer bucal, associação entre sintomas orais, regiões orais e história patológica pregressa e educação e prevenção no contexto do HPV. A análise estatística foi realizada com o teste qui-quadrado e considerando p < 0,05. Resultados: em comparação ao sexo feminino,jovens do sexo masculino apresentaram maior vulnerabilidade ao HPV, devido a início sexual precoce, múltiplas parcerias sexuais e sexo oral desprotegido,e ao câncer bucal mediado por álcool, além de menor conhecimento geral sobre o HPV. Em ambos os sexos, verrugas genitais figuraram como as doenças prévias mais prevalentes (5% do total), havendo associação em homens para a sintomatologia de garganta e as demais DST. Conclusão: a população jovem de Niterói apresenta comportamentos sexuais e de risco, como vulnerabilidade à infecção por HPV e grande consumo de álcool, que aumentam asuscetibilidade à carcinogênese em cabeça e pescoço. Deve existir maior articulação das políticas públicas de Saúde para a promoção de ações educativa se preventivas no campo de DST e de combate ao etilismo precoce.

The association of human papillomavirus (HPV) to squamous cell carcinoma in the region of head and neck represents a public health problem, especially to young people who are more prone to sexually transmited diseases (STD). Objective: to assess the vulnerability to transmission of HPV and head and neck cancer in young population from the city of Niteroi. Methods: an exploratory and descriptive study was conducted using questionnaires with 450 participants. The data were divided into socio-demographic characteristics, sexual behavior, risk factors for oral cancer, association between oral symptoms, oral regions and medical history and education and prevention in the context of HPV. Statistical analysis was performed usingchi-squared test and considering p < 0.05. Results: in comparison to females, young males were more vulnerable to HPV due to early sexual debut,multiple sexual partners and unsafe oral sex, and to oral cancer mediated by alcohol, and lower general knowledge about HPV. In both sexes, genital wartspre-figured as the most prevalent diseases (5% of total), with association in men to the symptoms of throat and the other STD. Conclusion: the young population from Niteroi presents risky sexual behaviours such as vulnerability to HPV infection and high alcohol consumption which increase suscetibilityto carcinogenesis in head and neck. There should be greater coordination of public health policies to promote educational preventive actions in the of STD and to combat early alcohol abuse.