Detalles de la búsqueda
1.
The Potentially Significant Role of CYP3A-Mediated Oxidative Metabolism of Dabigatran Etexilate and Its Intermediate Metabolites in Drug-Drug Interaction Assessments Using Microdose Dabigatran Etexilate.
Drug Metab Dispos
; 51(9): 1216-1226, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37230768
2.
In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans.
Xenobiotica
; 46(10): 882-95, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26864332
3.
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Bioorg Med Chem Lett
; 25(3): 444-50, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25577040
4.
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Bioorg Med Chem Lett
; 25(21): 4992-4999, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25613676
5.
Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.
Br J Clin Pharmacol
; 78(3): 587-98, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24617605
6.
siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.
Pharm Res
; 31(12): 3445-60, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24980206
7.
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
Bioorg Med Chem Lett
; 24(9): 2079-85, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24704030
8.
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Bioorg Med Chem Lett
; 24(20): 4884-90, 2014 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25248679
9.
Assessing the relative contribution of CYP3A-and P-gp-mediated pathways to the overall disposition and drug-drug interaction of dabigatran etexilate using a comprehensive mechanistic physiological-based pharmacokinetic model.
Front Pharmacol
; 15: 1356273, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38515840
10.
In vitro assessment of drug-drug interaction potential of boceprevir associated with drug metabolizing enzymes and transporters.
Drug Metab Dispos
; 41(3): 668-81, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23293300
11.
The impact of glycosylation on the pharmacokinetics of a TNFR2:Fc fusion protein expressed in Glycoengineered Pichia Pastoris.
Pharm Res
; 30(3): 803-12, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23135825
12.
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Bioorg Med Chem Lett
; 23(24): 6620-4, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24215892
13.
Binding characteristics of pyrrole-scaffold hepatitis B virus capsid inhibitors and identification of novel potent compounds.
RSC Adv
; 13(41): 29004-29022, 2023 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37807973
14.
Lymphatic transport and catabolism of therapeutic proteins after subcutaneous administration to rats and dogs.
Drug Metab Dispos
; 40(5): 952-62, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22328584
15.
Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology.
J Biol Chem
; 285(22): 17054-64, 2010 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-20356837
16.
Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences.
Drug Metab Dispos
; 39(9): 1469-77, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21610128
17.
Theoretical analysis of interplay of therapeutic protein drug and circulating soluble target: temporal profiles of 'free' and 'total' drug and target.
Pharm Res
; 28(10): 2447-57, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21614635
18.
Pyridyl amides as potent inhibitors of T-type calcium channels.
Bioorg Med Chem Lett
; 21(6): 1692-6, 2011 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316226
19.
Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: a comparative study with CHO produced materials.
Biologicals
; 39(4): 205-10, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21723741
20.
Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application.
J Pharm Sci
; 110(5): 2301-2310, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33609522