RESUMEN
OBJECTIVE: To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group. METHODS: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. RESULTS: QoL was worse in PD patients (nâ¯=â¯692; 62.6⯱â¯8.9 years old, 60.3% males) than controls (nâ¯=â¯206; 61⯱â¯8.3 years old, 49.5% males): PDQ-39, 17.1⯱â¯13.5 vs 4.4⯱â¯6.3 (pâ¯<â¯0.0001); PQ-10, 7.3⯱â¯1.6 vs 8.1⯱â¯1.2 (pâ¯<â¯0.0001); EUROHIS-QOL8, 3.8⯱â¯0.6 vs 4.2⯱â¯0.5 (pâ¯<â¯0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (râ¯=â¯0.72; pâ¯<â¯0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (râ¯=â¯0.65; pâ¯<â¯0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (ßâ¯=â¯0.32, 0.28, and 0.27, respectively; pâ¯<â¯0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, ßâ¯=â¯-0.46 and -0.21, respectively; EUROHIS-QOL8, ßâ¯=â¯-0.44 and -0.23, respectively). CONCLUSIONS: QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.