RESUMEN
BACKGROUND: Peroral endoscopic myotomy (POEM) is an established treatment for achalasia cardia; however, post-POEM gastroesophageal reflux (GER) remains a significant problem. Concomitant endoscopic fundoplication following POEM (POEMâ+âF) was recently described to reduce post-POEM GER. This single-center study reports short-term outcomes of POEMâ+âF. METHODS: This was a retrospective analysis of a prospectively maintained database of patients undergoing POEMâ+âF. Abstracted data included demographics, achalasia type, pre-POEM Eckardt score, prior therapy, follow-up.âFollow-up assessment was 3-monthly for 1 year and included post-POEM Eckardt score, GerdQ score, wrap integrity and esophagitis on esophagogastroduodenoscopy, and pH studies. GER was defined according to Lyon Consensus. RESULTS: 25 patients underwent POEMâ+âF (mean age 40.1 years [standard deviation (SD) 13.7]; 12 females). POEMâ+âF was technically successful in 23/25 (92.0â%). Significant dysphagia improvement was seen in all 25 patients (mean pre- and post-POEM Eckardt scores 8.21 [SD 1.08] and 0.1 [SD 0.3], respectively; Pâ=â0.001). Mean total procedure and fundoplication times were 115.6 (SD 27.2) minutes and 46.7 (SD 12.4) minutes, respectively; times reduced significantly after the initial five cases. Median follow-up was 12 months (interquartile range [IQR] 9-13). Intact wrap was seen in 19/23 (82.6â%). GER (abnormal esophageal acid exposure time [EAET]) was seen in 2/18 (11.1â%) and there was one reported GerdQ >â8.âBorderline GER (asymptomatic grade A esophagitis, normal EAET) was identified in 4/22 (18.2â%). Three (12.0â%) minor delayed adverse events occurred but required no intervention. CONCLUSIONS : POEMâ+âF was safe and reproducible. At 12 months' follow-up, incidence of post-POEMâ+âF GER was low and acceptable.
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Acalasia del Esófago , Reflujo Gastroesofágico , Miotomía , Cirugía Endoscópica por Orificios Naturales , Adulto , Acalasia del Esófago/cirugía , Esfínter Esofágico Inferior/cirugía , Femenino , Estudios de Seguimiento , Fundoplicación/efectos adversos , Reflujo Gastroesofágico/etiología , Reflujo Gastroesofágico/prevención & control , Reflujo Gastroesofágico/cirugía , Humanos , Miotomía/efectos adversos , Cirugía Endoscópica por Orificios Naturales/efectos adversos , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
INTRODUCTION: Hirschsprung's disease (HSCR) is congenital aganglionosis affecting the hindgut and presents with constipation. Surgical pull-through is the current standard treatment but causes morbidity. Per-rectal endoscopic myotomy is a novel third-space endoscopy technique for treating short-segment (SS)-HSCR. METHODS: Retrospective study of SS-HSCR patients diagnosed on history, contrast enema, rectal biopsies, and anorectal manometry, and treated by PREM. The aganglionic segment was mapped before PREM was performed using third-space endoscopy principles. Stool frequency and laxative usage before and after PREM were compared. RESULTS: Nine patients (age 7.5 [±â5.2] years; 7 male) underwent PREM during a 4-year period. Mean aganglionic segment length was 6.3âcm, mean procedure time 96.1 minutes, and mean length of hospital stay 2.5 days. Median follow-up was 17 months (range 9-58 months). Stool frequency was 1/4.4 days before vs. 1/1.2 days after PREM (Pâ=â0.0004). Mean laxative usage was 5.4 units of laxative (UL) before vs. 0.4 UL after PREM (Pâ=â0.0002). No laxatives were used by 6/9 patients after PREM. The single adverse effect seen (anal stenosis) was treated with dilatation. CONCLUSIONS: PREM is a safe and effective minimally invasive procedure to treat SS-HSCR and results in long-term response.
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Procedimientos Quirúrgicos del Sistema Digestivo , Enfermedad de Hirschsprung , Miotomía , Niño , Endoscopía , Enfermedad de Hirschsprung/cirugía , Humanos , Masculino , Estudios RetrospectivosRESUMEN
BACKGROUND AND AIM: Endoscopic ultrasonography (EUS)-guided drainage of walled-off necrosis (WON) may be carried out by placement of multiple plastic stents (MPS) or specially designed fully covered bi-flanged metal stents (BFMS). Comparative data on efficacy of these two stent types for WON drainage are limited. This retrospective study compares outcomes of WON drainage using BFMS and MPS. METHODS: During a 10-year period, 133 patients underwent EUS-guided WON drainage. MPS or BFMS were placed in a WON cavity through a single puncture, and direct endoscopic necrosectomy (DEN) was carried out whenever clinically necessary. Data in the two cohorts were retrospectively compared for primary outcomes - clinical success, adverse events and mortality; and secondary outcomes - DEN requirement, mean DEN sessions, need for salvage surgery and hospital stay. RESULTS: MPS were placed in 61 and BFMS in 72 patients. Patients undergoing BFMS drainage required fewer DEN sessions (mean 1.46 vs 2.74, P < 0.05), had fewer adverse events (5.6% vs 36.1%, P < 0.05), needed salvage surgery less often (2.7% vs 26.2%, P < 0.05), and had significantly shorter hospital stay (4.1 vs 8 days, P < 0.05) compared to those undergoing MPS drainage. There was no difference in DEN requirement (P = 0.217) and mortality (P = 0.5) in both groups. Overall clinical success with BFMS was superior to MPS (94% vs 73.7%, P < 0.05). CONCLUSION: BFMS appear to be superior to MPS for EUS-guided WON drainage in terms of clinical success, number of DEN sessions, adverse events, need for salvage surgery and hospital stay.
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Drenaje/métodos , Endosonografía/métodos , Predicción , Páncreas/diagnóstico por imagen , Pancreatitis Aguda Necrotizante/cirugía , Stents , Cirugía Asistida por Computador/métodos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Procedimientos Quirúrgicos del Sistema Digestivo/métodos , Diseño de Equipo , Femenino , Estudios de Seguimiento , Humanos , Tiempo de Internación/tendencias , Masculino , Persona de Mediana Edad , Páncreas/cirugía , Pancreatitis Aguda Necrotizante/diagnóstico , Estudios Retrospectivos , Resultado del Tratamiento , Adulto JovenRESUMEN
Hirschsprung's disease (HD) is a congenital disorder characterized by the absence of intrinsic ganglion cells in submucosal and myenteric plexuses of the hindgut; and presents with constipation, intestinal obstruction and/or megacolon. HD commonly involves the rectosigmoid region (short segment HD), although shorter and longer variants of the disease are described. Standard treatment involves pull-through surgery for short segment HD or posterior anorectal myotomy in selected ultrashort segment candidates. Third space endoscopy has evolved during the past few years. Per oral endoscopic myotomy and per oral pyloromyotomy are described for treatment of achalasia cardia and refractory gastroparesis, respectively. Using the same philosophy of muscle/sphincter disruption for spastic bowel segments, per rectal endoscopic myotomy could be considered as a treatment option for short segment HD. A 24-year-old male patient presented with refractory constipation since childhood, and habituated to high-dose laxative combinations. Diagnosis was confirmed as adult short segment HD by barium enema, colonoscopic deep suction mucosal biopsies and anorectal manometry. Histopathology confirmed aganglionosis in the distal 15 cm. By implementing principles of third space endoscopy, per rectal endoscopic myotomy 20 cm in length was successfully carried out. At 24-week follow up, the patient reported significant relief of constipation and associated symptoms. Sigmoidoscopy, anorectal manometry and barium enema confirm improved rectal distensibility and reduced rectal pressures. The present case report describes the first human experience of per rectal endoscopic myotomy for successful treatment of adult short segment HD.
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Enfermedad de Hirschsprung/cirugía , Miotomía , Adulto , Colon Sigmoide , Estreñimiento , Humanos , Masculino , Recto , Adulto JovenAsunto(s)
Acalasia del Esófago , Esofagitis Péptica , Reflujo Gastroesofágico , Laparoscopía , Miotomía , Cirugía Endoscópica por Orificios Naturales , Acalasia del Esófago/cirugía , Fundoplicación , Reflujo Gastroesofágico/etiología , Reflujo Gastroesofágico/prevención & control , Humanos , Miotomía/efectos adversos , Cirugía Endoscópica por Orificios Naturales/efectos adversos , Resultado del TratamientoRESUMEN
BACKGROUND: This is a report of an IRB-approved pilot study of 13 patients who received a trans-oral anterior partial fundoplication for the treatment of GERD using an ultrasound-guided, flexible surgical stapler. All patients had a history of PPI use, objective evidence of GERD, and no significant comorbidity. Under general anesthesia, a flexible stapler was passed trans-orally into the stomach and placed two or three quintuplets of titanium staples approximately 3 cm above the gastroesophageal junction. The stapler contains an ultrasonic range finder, video camera, and illuminator. METHODS: Primary follow-up at 6 weeks included pH metrics, GERD-HRQL scores, and PPI use. The protocol allowed annual telephone interviews for the following 5 years to collect GERD-HRQL scores, PPI use, satisfaction with the procedure, and willingness to have the procedure again. RESULTS: At 6 weeks, mean total acid exposure was significantly reduced, and 12/13 patients reduced GERD-HRQL scores by ≥50%. Twelve of 13 patients had stopped daily GERD medications, and nine of 13 had stopped all GERD medications. Each year, 11 of the 13 patients could be reached with all 13 patients having at least 4-year follow-up. Throughout the follow-up period, GERD-HRQL scores were normal (<10) in all but one patient. All patients would agree to do the procedure again. The median satisfaction score is 8 (range 6-10) on a scale of 1-10. None reported dysphagia. At 1 year, 54% of respondents (6/11) had eliminated PPI use, with another 27% (3/11) taking a reduced dose. Combining respondents at 4 and 5 years to account for all patients, 54% (7/13) had eliminated and another 23% (3/13) reduced PPI use ≥50 %. CONCLUSION: At 5 years, the procedure remained effective as demonstrated by the improved quality of life and changes in PPI use. The results remained stable after the second year.
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Fundoplicación/métodos , Reflujo Gastroesofágico/cirugía , Gastroscopía/métodos , Cirugía Endoscópica por Orificios Naturales/métodos , Adulto , Unión Esofagogástrica/cirugía , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Satisfacción del Paciente/estadística & datos numéricos , Proyectos Piloto , Grapado Quirúrgico , Resultado del TratamientoAsunto(s)
Canal Anal/cirugía , Enfermedad de Hirschsprung/cirugía , Miotomía/métodos , Recto/cirugía , Niño , Colonoscopía , Humanos , MasculinoRESUMEN
Background and aim Accurate estimation of the distance to the gastroesophageal junction (GEJ) through a tunnel during per oral endoscopic myotomy (POEM) is technically challenging. The methods currently employed are often insufficient, and resultant errors may lead to incomplete myotomy and/or prolonged procedure times. Our hypothesis states that the additional distance while traversing the tunnel is directly proportional to the widest esophageal diameter; and is calculated by the formula Xâ=âYâ+âCZ (Xâ=âdistance to the GEJ through the tunnel, Yâ=âdistance to the GEJ through the lumen, Zâ=âwidest esophageal diameter, Câ=âarithmetic constant). This study evaluates the validity and accuracy of this hypothesis. Patients and methods This was a prospective single-center study with 80 patients, 12 in the pilot group and 68 in the study group.âIn the pilot group, Y was recorded during esophagogastroduodenoscopy (EGD) before POEM, Z on barium swallow/contrast enhanced computed tomography (CECT), and X was measured during POEM. Using the formula, mean C (SD) was calculated. In the study group, 'C' was substituted in the equation to predict the GEJ distance through the tunnel (Xp) before POEM. The operator was blinded to Xp and recorded the true Xt during POEM. The correlation between Xp and Xt was calculated. Results In the pilot group, the mean distances (cm, SD) for X, Y, and Z were 42.58 (3.33), 39.83 (3.08), and 4.39 (1.16), respectively. The calculated mean C was 0.63 (0.11). In the study group, the mean distances (cm, SD) for Y, Z, Xp, and Xt were 40.45 (2.58), 4.99 (1.43), 43.57 (2.68), and 43.54 (2.78), respectively. The Xp and Xt values demonstrated a high correlation (râ=â0.97, P â=â0.000). Conclusions Formula Xâ=âYâ+âCZ reliably predicts the GEJ distance through a tunnel during POEM. It is user friendly and requires no additional resources.
RESUMEN
Achalasia cardia is the commonest esophageal motility disorder. Recently, a new endoscopic procedure-peroral endoscopic myotomy (POEM)-has emerged for treating this chronic and debilitating condition. It has shown comparable success rates in prospective studies with conventional Heller's myotomy with lesser rates of postoperative reflux. Literature regarding this procedure from India is scarce due to its limited availability. This case report illustrates the use of POEM in a patient with a permanent cardiac pacemaker and demonstrates its safety and efficacy in such a situation.