RESUMEN
Six new acylphloroglucinols (1 - 6) were isolated from Dryopteris championii. Their structures were established on the basis of extensive analysis of spectroscopic data and comparison with reported data. The antibacterial activities of the isolates were evaluated against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Dickeya zeae.
Asunto(s)
Antibacterianos/aislamiento & purificación , Dryopteris/química , Floroglucinol/aislamiento & purificación , Antibacterianos/química , Bacterias/efectos de los fármacos , Estructura Molecular , Floroglucinol/química , Floroglucinol/farmacología , Extractos Vegetales/química , Extractos Vegetales/farmacología , Análisis EspectralRESUMEN
Phytochemical investigation of the ethanol extract from the twigs and leaves of Croton tiglium led to the isolation of two new phorbol esters (1-2) and seven known ones (3-9). Their structures were elucidated by the analyses of extensive spectroscopic data (IR, MS, and 1D and 2D NMR) and comparing with related compounds. Meanwhile, compounds 1-9 were determined for their cytotoxic activities on human lung cancer cell line A549. Among them, 1-2 were inactive against the cell line A549 (IC50 > 100 µM), but compounds 3 and 7 showed weak activities.