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1.
Br J Haematol ; 203(4): 546-563, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37586700

RESUMEN

The objective of this guideline is to provide healthcare professionals with clear, up-to-date and practical guidance on the management of thrombotic thrombocytopenic purpura (TTP) and related thrombotic microangiopathies (TMAs), including complement-mediated haemolytic uraemic syndrome (CM HUS); these are defined by thrombocytopenia, microangiopathic haemolytic anaemia (MAHA) and small vessel thrombosis. Within England, all TTP cases should be managed within designated regional centres as per NHSE commissioning for highly specialised services.


Asunto(s)
Anemia Hemolítica , Hematología , Síndrome Hemolítico-Urémico , Púrpura Trombocitopénica Trombótica , Microangiopatías Trombóticas , Humanos , Púrpura Trombocitopénica Trombótica/diagnóstico , Púrpura Trombocitopénica Trombótica/terapia , Microangiopatías Trombóticas/diagnóstico , Microangiopatías Trombóticas/etiología , Microangiopatías Trombóticas/terapia , Síndrome Hemolítico-Urémico/diagnóstico , Anemia Hemolítica/diagnóstico
2.
Haemophilia ; 22(2): 285-291, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26422253

RESUMEN

INTRODUCTION: In a minority of patients with a significant bleeding history no cause is found despite extensive testing and we diagnose such cases as unclassified bleeding disorders (UBD). UBDs may have diverse underlying causes and currently no standard management strategy exists in the event of a haemorrhage or to cover surgery. AIM: To document the clinical characteristics and response to treatment of UBDs. METHODS: We performed a retrospective chart review of all patients with UBDs who had an invasive procedure at our centre between 1998 and 2014. RESULTS: The commonest symptoms were menorrhagia (89%) and bleeding at the time of surgery (88%) or dental extraction (85%). A total of 33 patients underwent 78 minor and major haemostatic challenges. Haemostatic cover was provided in 28 procedures with tranexamic acid alone, two with desmopressin and 45 with both agents in combination. A successful haemostatic outcome was observed in 70/78 (90%) cases. No patient required additional surgical intervention to achieve haemostasis, but one patient required a platelet transfusion to control postoperative bleeding. CONCLUSIONS: This is the first study to report on the investigation and treatment of UBD. Future studies are needed to further our understanding of the bleeding phenotype and identify any underlying causes.

3.
Transfus Med ; 22(5): 350-5, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22697297

RESUMEN

BACKGROUND: Massive haemorrhage occurs in a variety of clinical settings resulting in consumptive and dilutional coagulopathies leading to hypofibrinogenaemia. METHODS/MATERIALS: A prospective observational national cohort study was performed between November 2008 and June 2010 to collect safety data on the off-label use of a fibrinogen concentrate to treat acquired hypofibrinogenaemia. RESULTS: A prospective cohort of 63 patients with varying causes of hypofibrinogenaemia resulted from this data collection. A single infusion of fibrinogen concentrate was given in 49 (77%) of patients studied and 12 received more than one infusion. The median inter-quartile range (IQR) dose of fibrinogen infused was 49 (26-61) mg kg(-1). The median (IQR) fibrinogen level before and after infusion was 0.9 (0.6-1.3) and 1.8 (1.4-4.3) g L(-1), respectively (P < 0.001). In 31 patients (67%), bleeding stopped within 4 h and fibrinogen was reported to have contributed to this outcome by the treating clinicians. In 84% of cases the treating clinician reported that the use of fibrinogen concentrate reduced the rate of bleeding. Fibrinogen was associated with a statistically significant reduction in red blood cell transfusion (median 4 units before and 0 units after, P < 0.001) and fresh frozen plasma infusion (median 4 units before and 0 units after, P < 0.001). Three venous and one arterial non-fatal thrombotic events were recorded in the patients treated with fibrinogen. CONCLUSION: Fibrinogen concentrate can be used to correct hypofibrinogenaemia and may reduce blood product usage.


Asunto(s)
Afibrinogenemia/tratamiento farmacológico , Coagulantes/administración & dosificación , Fibrinógeno/administración & dosificación , Adolescente , Adulto , Afibrinogenemia/sangre , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Estudios de Cohortes , Femenino , Hemorragia/sangre , Hemorragia/tratamiento farmacológico , Humanos , Lactante , Recién Nacido , Masculino , Auditoría Médica , Persona de Mediana Edad , Estudios Prospectivos , Reino Unido
5.
Cochrane Database Syst Rev ; (1): CD004226, 2005 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-15674934

RESUMEN

BACKGROUND: Fetomaternal alloimmune thrombocytopenia occurs when the mother produces antibodies against a platelet alloantigen that the fetus has inherited from the father. A consequence of this can be a reduced number of platelets (thrombocytopenia) in the fetus, which can result in bleeding whilst in the womb or shortly after birth. In severe cases this bleeding may lead to long-lasting disability or death. Antenatal management of fetomaternal alloimmune thrombocytopenia centres on preventing severe thrombocytopenia in the fetus. Available management options include administration of intravenous immunoglobulins or corticosteroids to the mother or intrauterine transfusion of antigen compatible platelets to the fetus. All options are costly and need to be assessed in terms of potential risk and benefit to both the mother and an individual fetus. OBJECTIVES: To determine the optimal antenatal treatment of fetomaternal alloimmune thrombocytopenia to prevent fetal and neonatal haemorrhage and death. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register (February 2004), EMBASE (1980 to February 2004) and bibliographies of relevant publications and review articles. SELECTION CRITERIA: Randomised controlled studies comparing any intervention, including corticosteroids with no treatment, or comparing any two interventions. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed eligibility, trial quality and extracted data. MAIN RESULTS: One study met the inclusion criteria (54 pregnant women). This trial compared intravenous immunoglobulins plus corticosteroid (dexamethasone) with intravenous immunoglobulins alone. No significant differences were reported between the treatment and control groups, in any outcome measured: mean platelet count at birth (weighted mean difference (WMD) 14.10 x 10 9/l, 95% confidence interval (CI) -30.26 to 58.46), mean gestational age at birth (WMD -0.50 weeks, 95% CI -2.69 to 1.69), mean rise in platelet count from first to second fetal blood screen (WMD -3.50 x 10 9/l, 95% CI -24.62 to 17.62) and mean rise in platelet count from birth to first fetal blood screen (WMD 24.40 x 10 9/l (95% CI -14.17 to 62.97)). This trial had adequate methodological quality; however the method used to calculate sample size was inappropriate: therefore the power calculation was not sufficient to determine any significance in differences between the treatment groups. AUTHORS' CONCLUSIONS: There are insufficient data from randomised controlled trials to determine the optimal antenatal management of fetomaternal alloimmune thrombocytopenia. Future trials should consider the dose of intravenous immunoglobulins, the timing of initial treatment, monitoring of response to treatment by fetal blood sampling, laboratory measures to define pregnancies with a high risk of intercranial haemorrhage, management of non-responders and long-term follow up of children.


Asunto(s)
Enfermedades Fetales/terapia , Glucocorticoides/uso terapéutico , Inmunoglobulinas Intravenosas/uso terapéutico , Trombocitopenia/terapia , Antígenos de Plaqueta Humana/inmunología , Transfusión de Sangre Intrauterina , Dexametasona/uso terapéutico , Femenino , Enfermedades Fetales/inmunología , Humanos , Transfusión de Plaquetas , Embarazo , Trombocitopenia/inmunología
7.
Int J Obstet Anesth ; 20(2): 135-41, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21439811

RESUMEN

BACKGROUND: Postpartum haemorrhage is an important cause of maternal morbidity and mortality. It is associated with haemostatic impairment which may exacerbate bleeding. METHODS: All deliveries over a 3-year period in a large UK unit were reviewed and cases of haemorrhage of 1500 mL or more identified. Laboratory records were reviewed and the lowest value for haemoglobin, platelet count and fibrinogen, and longest value for prothrombin time and activated partial thromboplastin time within 24h of delivery were recorded. RESULTS: Of 18,501 deliveries there were 456 bleeds of 1500 mL or more (2.5%). Fibrinogen levels correlated best with blood loss (r -0.48 P<0.01) and fell progressively as volume increased. Activated partial thromboplastin time was less sensitive (r 0.4 P<0.01) to increasing blood loss. Prothrombin time did not correlate with blood loss (r 0.01). Activated partial thromboplastin time and prothrombin time remained within the normal range in most women despite large bleeds. Similar results were observed in women who received four or more units of red blood cells. Haemoglobin level was adequately maintained irrespective of blood loss. Based on UK national guidelines only 13 of 456 (3%) women should have received fresh frozen plasma, although it was given to 45; despite this, fibrinogen levels below the pregnancy-related normal range were observed in most cases. CONCLUSION: Fibrinogen level was the parameter that best correlated with increasing volume of haemorrhage and was the most useful marker of developing haemostatic impairment. Guidelines for fresh frozen plasma use in major postpartum haemorrhage were rarely followed and should be reviewed.


Asunto(s)
Hemostasis , Hemorragia Posparto/sangre , Adolescente , Adulto , Femenino , Fibrinógeno/análisis , Hemoglobinas/análisis , Humanos , Persona de Mediana Edad , Tiempo de Tromboplastina Parcial , Plasma , Hemorragia Posparto/terapia
8.
Int J Obstet Anesth ; 19(2): 218-23, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20194010

RESUMEN

Haemorrhage is a common complication of childbirth with 0.65% of deliveries associated with significant (>1500 mL) peripartum blood loss. Hypofibrinogenaemia secondary to dilutional and consumptive coagulopathies can be challenging to correct quickly with conventional blood and plasma therapy. Fibrinogen concentrate offers rapid restoration of fibrinogen levels with a small volume infusion and minimal preparation time. It is effective in treating patients with congenital hypofibrinogenaemia, but there are few reports of its use in association with continuing obstetric haemorrhage. Six cases of obstetric haemorrhage, associated with hypofibrinogenaemia, treated with fibrinogen concentrate in conjunction with platelets, fresh frozen plasma, packed red blood cells, uterotonics and obstetric intervention are described. In all cases, laboratory assessed coagulation was rapidly normalised and severe haemorrhage improved. These cases suggest that fibrinogen concentrate may be an effective addition to conventional treatments for obstetric haemorrhage associated with hypofibrinogenaemia.


Asunto(s)
Afibrinogenemia/tratamiento farmacológico , Coagulantes/uso terapéutico , Fibrinógeno/uso terapéutico , Hemorragia Posparto/tratamiento farmacológico , Adulto , Afibrinogenemia/sangre , Afibrinogenemia/etiología , Pruebas de Coagulación Sanguínea , Femenino , Fibrinógeno/análisis , Fibrinógeno/fisiología , Humanos , Hemorragia Posparto/etiología , Embarazo , Adulto Joven
9.
Nurs Times ; 65(17): 545, 1969 Apr 24.
Artículo en Inglés | MEDLINE | ID: mdl-5780649

Asunto(s)
Enfermería
10.
Br J Plast Surg ; 40(5): 485-7, 1987 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-3676574

RESUMEN

In order to reduce the incidence of skin edge necrosis following dissection of the inguinal lymph nodes, an abdominal rotation flap has been used to help with closure. This allows excision of the most vulnerable skin, and closure without tension. Our experience in 13 groin dissections is presented, with skin edge necrosis in one patient (7.6%). This is compared with previously reported series and the reasons for the precarious blood supply to the skin following groin dissection are discussed.


Asunto(s)
Escisión del Ganglio Linfático/métodos , Colgajos Quirúrgicos , Adulto , Anciano , Femenino , Ingle , Humanos , Masculino , Persona de Mediana Edad , Necrosis/prevención & control , Piel/patología
11.
Br J Plast Surg ; 40(6): 592-7, 1987 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-3690091

RESUMEN

The technique of cross-facial nerve transplantation (CFNT), with or without the addition of vascularised muscle, has made it possible to achieve some voluntary movement of the paralysed side of the face in patients with unrecovered facial palsy. If normal faces are studied during conversation, it can be seen that there are two types of movement of the lips--those of emotional expression and those involved in the formation of vowel sounds and labial consonants. Smiles themselves can be classified roughly according to their length of muscle contraction--the longer "definitive" smile, and the shorter "flash" smile. It is the synergistic facial movement of the unpremeditated "flash" smile and the small movements in the formation of the vowel sounds and labial consonants which fail to occur in patients reanimated by revascularised, reinnervated muscle, despite the return of voluntary contraction and resting facial tone. This study was undertaken to try to determine why these synergistic facial movements of short duration are so difficult to achieve.


Asunto(s)
Expresión Facial , Nervio Facial/trasplante , Parálisis Facial/cirugía , Sonrisa , Cirugía Plástica , Adulto , Preescolar , Electromiografía , Nervio Facial/fisiopatología , Parálisis Facial/fisiopatología , Humanos , Persona de Mediana Edad
12.
Burns Incl Therm Inj ; 14(6): 468-72, 1988 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-3250718

RESUMEN

The clinical assessment of burn depth can be particularly difficult in children. A new technique is described for applying the pin-prick test in children. It is simple to perform, causes no distress, and has consistently given reliable results. A personal series of 196 cases is presented, with a 95 per cent diagnostic accuracy.


Asunto(s)
Quemaduras/diagnóstico , Niño , Preescolar , Femenino , Humanos , India , Lactante , Masculino , Reflejo de Sobresalto , Reino Unido
13.
Br J Plast Surg ; 39(1): 72-5, 1986 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-3947797

RESUMEN

Radical surgery in the neck is hazardous after irradiation. Rupture of the carotid artery may lead to uncontrollable haemorrhage. Reported mortality rates following this serious complication are between 18% and 50% (Heller and Strong, 1979). We describe a simple method for controlling acute carotid haemorrhage using a standard Fogarty biliary catheter, with selective detachable balloon embolisation for permanent occlusion of the carotid artery.


Asunto(s)
Enfermedades de las Arterias Carótidas/prevención & control , Cateterismo , Embolización Terapéutica , Hemorragia/prevención & control , Cuello/cirugía , Arterias Carótidas/efectos de la radiación , Humanos , Complicaciones Intraoperatorias/prevención & control , Neoplasias Laríngeas/radioterapia , Masculino , Persona de Mediana Edad , Radioterapia/efectos adversos
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