Tumefactive Crohn's Disease Mimicking Colon Carcinoma in a Young Female: A Case Report.

Tumefactive Crohn's disease is a rare form of Crohn's disease that may mimic colon carcinoma macroscopically. This case report describes a 28-year-old female who presented with right-sided abdominal pain and a palpable abdominal mass that had persisted for over a month. Multiple hospitalizations failed to provide an accurate diagnosis until an exploratory laparotomy revealed that the "mass" was the cecum and a perforated ascending colon. A partial right colectomy was performed, sending the specimen for biopsy. The microscopic description showed dense and confluent chronic inflammation in the colonic mucosa and wall, extending to the serosa in some regions. The infiltration comprised lymphocytes and plasma cells, with an admixture of some neutrophils. Aphthous mucosal ulcerations, intramural fissures, and fistulas were present. Immunostains for pan-keratin demonstrated no intramural epithelial elements. The characteristics of this lesion represent tumefactive Crohn's disease. This case highlights the key microscopic characteristics that pathologists look for when differentiating Crohn's disease from colon carcinoma in a patient presenting with abdominal pain and a colon mass.

From Fibroids to Fasciitis: A Rare Case of Necrotizing Fasciitis Post-Abdominal Hysterectomy.

Necrotizing fasciitis is a life-threatening bacterial infection characterized by rapid tissue destruction and systemic inflammation. Although it is rare, it can occur at surgical incision sites in procedures such as open abdominal hysterectomy. Prompt diagnosis and treatment are essential to prevent sepsis and multi-organ failure. We present a case of a 39-year-old morbidly obese African American woman with a history of type II diabetes that developed necrotizing fasciitis at a transverse incision site following an abdominal hysterectomy. The infection was complicated by a urinary tract infection caused by Proteus mirabilis. Surgical debridement and antibiotic therapy were successfully employed to treat the infection. This case emphasizes the importance of clinical suspicion, early intervention, and appropriate antimicrobial therapy in managing necrotizing fasciitis at incision sites, particularly in patients with additional risk factors.