Generative models improve fairness of medical classifiers under distribution shifts.

Domain generalization is a ubiquitous challenge for machine learning in healthcare. Model performance in real-world conditions might be lower than expected because of discrepancies between the data encountered during deployment and development. Underrepresentation of some groups or conditions during model development is a common cause of this phenomenon. This challenge is often not readily addressed by targeted data acquisition and 'labeling' by expert clinicians, which can be prohibitively expensive or practically impossible because of the rarity of conditions or the available clinical expertise. We hypothesize that advances in generative artificial intelligence can help mitigate this unmet need in a steerable fashion, enriching our training dataset with synthetic examples that address shortfalls of underrepresented conditions or subgroups. We show that diffusion models can automatically learn realistic augmentations from data in a label-efficient manner. We demonstrate that learned augmentations make models more robust and statistically fair in-distribution and out of distribution. To evaluate the generality of our approach, we studied three distinct medical imaging contexts of varying difficulty: (1) histopathology, (2) chest X-ray and (3) dermatology images. Complementing real samples with synthetic ones improved the robustness of models in all three medical tasks and increased fairness by improving the accuracy of clinical diagnosis within underrepresented groups, especially out of distribution.

AutoNovel: Automatically Discovering and Learning Novel Visual Categories.

We tackle the problem of discovering novel classes in an image collection given labelled examples of other classes. We present a new approach called AutoNovel to address this problem by combining three ideas: (1) we suggest that the common approach of bootstrapping an image representation using the labelled data only introduces an unwanted bias, and that this can be avoided by using self-supervised learning to train the representation from scratch on the union of labelled and unlabelled data; (2) we use ranking statistics to transfer the model's knowledge of the labelled classes to the problem of clustering the unlabelled images; and, (3) we train the data representation by optimizing a joint objective function on the labelled and unlabelled subsets of the data, improving both the supervised classification of the labelled data, and the clustering of the unlabelled data. Moreover, we propose a method to estimate the number of classes for the case where the number of new categories is not known a priori. We evaluate AutoNovel on standard classification benchmarks and substantially outperform current methods for novel category discovery. In addition, we also show that AutoNovel can be used for fully unsupervised image clustering, achieving promising results.