Zn-Catalyzed Dehydroxylative Phosphorylation of Allylic Alcohols with P(III)-Nucleophiles.

A novel and efficient protocol for the synthesis of diarylallyl-functionalized phosphonates, phosphinates, and phosphine oxides through the zinc-catalyzed dehydroxylative phosphorylation of allylic alcohols with P(III)-nucleophiles via a Michaelis-Arbuzov-type rearrangement is reported. A broad range of allylic alcohols and P(III)-nucleophiles (P(OR)3, ArP(OR)2, and Ar2P(OR)) are well tolerated in this reaction, and the expected dehydroxylative phosphorylation products could be synthesized with good to excellent yields under the optimal reaction conditions. The reaction can be easily scaled up at a gram-synthesis level. Furthermore, through the step-by-step control experiments, kinetic study experiments, and 31P NMR tracking experiments, we acquired insights into the reaction and proposed the possible mechanism for this transformation.

Characterization of an Alkaline Alginate Lyase with pH-Stable and Thermo-Tolerance Property.

Alginate oligosaccharides (AOS) show versatile bioactivities. Although various alginate lyases have been characterized, enzymes with special characteristics are still rare. In this study, a polysaccharide lyase family 7 (PL7) alginate lyase-encoding gene, aly08, was cloned from the marine bacterium Vibrio sp. SY01 and expressed in Escherichia coli. The purified alginate lyase Aly08, with a molecular weight of 35 kDa, showed a specific activity of 841 U/mg at its optimal pH (pH 8.35) and temperature (45 °C). Aly08 showed good pH-stability, as it remained more than 80% of its initial activity in a wide pH range (4.0-10.0). Aly08 was also a thermo-tolerant enzyme that recovered 70.8% of its initial activity following heat shock treatment for 5 min. This study also demonstrated that Aly08 is a polyG-preferred enzyme. Furthermore, Aly08 degraded alginates into disaccharides and trisaccharides in an endo-manner. Its thermo-tolerance and pH-stable properties make Aly08 a good candidate for further applications.

Why are older adults victims of fraud? Current knowledge and prospects regarding older adults' vulnerability to fraud.

Older adults are disproportionately targeted by various kinds of fraud, which result in irreversible economic losses and great psychological distress. Over the past years, researchers have conducted systematic research on the prevalence, under-reporting, and research methods of fraud victimization in older adults. Research paradigms regarding fraud victimization among older adults have mainly included cognitive, emotion regulation and motivation, and comprehensive paradigms. Factors shown to influence fraud victimization among older adults include cognitive decline, emotional regulation and motivational changes, their overly trusting nature, psychological vulnerability, social isolation, risk-taking, and a lack of knowledge and information regarding fraud prevention. Based on a review of the literature, future research can benefit from constructing a comprehensive fraud victimization theory, improving research methods, extending existing research, exploring physiological mechanisms of elderly fraud, and strengthening prevention and intervention efforts.

Recent Advances in the Application of P(III)-Nucleophiles to Create New P-C Bonds through Michaelis-Arbuzov-Type Rearrangement.

Organophosphorus compounds have long been considered valuable in both organic synthesis and life science. P(III)-nucleophiles, such as phosphites, phosphonites, and diaryl/alkyl phosphines, are particularly noteworthy as phosphorylation reagents for their ability to form new P-C bonds, producing more stable, ecofriendly, and cost-effective organophosphorus compounds. These nucleophiles follow similar phosphorylation routes as in the functionalization of P-H bonds and P-OH bonds. Activation can occur through photocatalytic, electrocatalytic, or thermo-driven reactions, often in coordination with a Michaelis-Arbuzov-trpe rearrangement process, to produce the desired products. As such, this review offers a thorough overview of the phosphorylated transformation and potential mechanisms of P(III)-nucleophiles, specifically focusing on developments since 2010. Notably, this review may provide researchers with valuable insights into designing and synthesizing functionalized organophosphorus compounds from P(III)-nucleophiles, guiding future advancements in both research and practical applications.

Catalyst- and Additive-free, Regioselective 1,6-Hydroarylation of para-Quinone Methides with Anilines in HFIP.

A simple and efficient method for the synthesis of diarylmethyl-functionalized anilines through the hexafluoroisopropanol (HFIP)-mediated regioselective 1,6-hydroarylation reaction of para-quinone methides (p-QMs) with anilines under catalyst- and additive-free conditions is reported. Various kinds of p-QMs and amines (e. g. primary, secondary and tertiary amines) are well tolerated in this transformation without the pre-protection of amino group, and the corresponding products could be generated with good to excellent yields and satisfactory regioselectivity under the optimized reaction conditions. In addition to adaptable amine compounds, indoles and their derivatives are also compatible with this reaction system. This transformation can be easily extended to a gram scale-synthesis level to synthesize the target product. Furthermore, it is worth noting that some complex small aniline molecules with biological activity can be selectively modified using this method. The possible reaction mechanism is proposed through the step-by-step control experiments and DFT calculations, showing that the key process for achieving the regioselective 1,6-hydroarylation of p-QMs is the hydrogen bonding effect of HFIP to substrates.

Simulating the Effect of Mixed Subsidy Policies on Urban Low-Value Recyclable Waste in China: A System Dynamics Approach.

Low-value recyclable waste accounts for a large portion of urban waste output in many modern cities. The improper management and disposal of LVRW result in environmental pollution and a waste of resources. Given the characteristics of a high recovery cost and low recovery income of low-value recyclables, it is difficult to obtain a satisfactory waste disposal effect by completely relying on the market mechanism. It is thus necessary for the government to implement effective subsidies for multiple subjects in the urban waste recycling system (UWRS). This study examines the independent roles of four subsidy policies-subsidy to the third-party waste disposal institutions, subsidy to a state-owned waste disposal institution, R&D subsidy for green technology, and subsidy for government publicity-and develops a system dynamics model to verify the performance of the UWRS under different combinations of subsidy-based policies under multiple scenarios. Data on urban waste disposal for Guangzhou from 2019 and 2020 were used to validate and simulate the model. A sensitivity analysis of the main exogenous variables was carried out, and the conclusions are as follows: (1) On the premise of a fixed subsidy capital pool, a mixed subsidy policy produced the best impact on the UWRS. (2) The total subsidy needed to reach a certain threshold; otherwise, the mixed subsidy policy did not improve the UWRS. The total subsidy produced diminishing returns once it had exceeded the threshold. (3) Appropriately reducing subsidies for the third-party waste disposal institutions within a reasonable range does not affect the performance of the UWRS. (4) The effect of government publicity has short-term advantages, while the long-term potential of green technology is greater. Multi-agent coordination and the guidance of the market mechanism are important priorities in the design of subsidy-based policies. In addition, the trade-off between subjects needs attention, and a plan for mixed subsidy policies needs to be designed and implemented according to the response periods of different policies. The research here provides theoretical support for the government for designing subsidy-based policies.

Parent-Child Cohesion, Basic Psychological Needs Satisfaction, and Emotional Adaptation in Left-Behind Children in China: An Indirect Effects Model.

This study aimed to validate an indirect effects model of parent-child cohesion in emotional adaptation (i.e., loneliness and depression) via basic psychological needs satisfaction in Chinese left-behind children as well as the applicability of the model to both genders. A cross-sectional study was conducted and included 1,250 children aged between 9 and 12 years (635 left-behind children and 615 non-left-behind children) from rural primary schools. The results showed that: (1) relative to non-left-behind children, left-behind children exhibited significantly higher loneliness and depression scores and greater disadvantages involving father-child cohesion, mother-child cohesion, and psychological needs satisfaction. (2) Father- and mother-child cohesion were significantly negatively correlated with loneliness and depression and significantly positively correlated with psychological needs satisfaction in left-behind children. (3) Through structural equation modeling showed that psychological needs satisfaction partially mediated the relationship between parent-child cohesion and emotional outcomes in left-behind children. (4) Through multi-group analyses showed significant gender differences in structural weighting between parent-child cohesion and emotional adaptation, in that parent-child cohesion in left-behind boys was a stronger negative predictor of unfavorable emotional outcomes relative to that observed in left-behind girls, while psychological needs satisfaction in left-behind girls was a stronger negative predictor of unfavorable emotional outcomes relative to that observed in left-behind boys. The implications of these findings for interventions directed at Chinese left-behind children were discussed.