[Cholestatic jaundice and constitutional syndrome as early manifestations of primary systemic amyloidosis]. / Ictericia colestásica y síndrome constitucional como debut de una amiloidosis sistémica primaria.

We present the case of a 70-year-old woman who had been suffering from constitutional syndrome for several months, abdominal distension, and yellowish coloration of the skin for the previous few days with a rapidly fatal course. Examination revealed hepatomegaly and ascites. Laboratory investigations revealed hyperbilirubinemia with cholestasis. The remaining investigations (abdominal ultrasound, barium transit evaluation, bone marrow study, analysis of ascitic fluid and laparoscopy) did not establish the diagnosis. This was established by liver and subcutaneous fatty tissue biopsies, which revealed type AL amyloid deposits. Autopsy confirmed that the patient had primary systemic amyloidosis. This infrequent form of presentation of systemic amyloidosis and its poor prognosis are discussed.

[Diffuse melanosis in metastatic malignant melanoma with melanuria]. / Melanosis difusa en melanoma maligno metastásico con melanuria.

We report an additional case of diffuse melanosis secondary to metastases from malignant melanoma in a patient, who was seen in our department shortly before death. We couldn't localize the origin of the primary neoplasm. After reporting the case, we discuss the pathogenesis of melanosis and possible sites of the primary tumor.