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1.
Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease.
J Pharmacol Exp Ther
; 380(3): 210-219, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35031585
2.
Differential Bile Acid Detection in Refractory GERD Patient Saliva Using a Simple and Sensitive Liquid Chromatography Tandem Mass Spectrometry Approach.
J Clin Gastroenterol
; 56(3): 218-223, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33731598
3.
Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials.
Diabetes Obes Metab
; 23(3): 700-710, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33289350
4.
EEG-ß/γ spectral power elevation in rat: a translatable biomarker elicited by GABA(Aα2/3)-positive allosteric modulators at nonsedating anxiolytic doses.
J Neurophysiol
; 113(1): 116-31, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25253471
5.
Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease.
Blood Adv
; 2024 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38640200
6.
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett
; 23(13): 3967-75, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23673016
7.
A membrane vesicle-based assay to enable prediction of human biliary excretion.
Xenobiotica
; 43(10): 915-9, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23402371
8.
A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: validation with clinical data.
Xenobiotica
; 43(7): 592-7, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23244592
9.
Assessment of CYP3A-mediated drug-drug interaction potential for victim drugs using an in vivo rat model.
Biopharm Drug Dispos
; 34(7): 396-401, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23873286
10.
A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.
Br J Clin Pharmacol
; 74(1): 98-108, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22122233
11.
Safety, Pharmacokinetics, and Pharmacodynamics of Etavopivat (FT-4202), an Allosteric Activator of Pyruvate Kinase-R, in Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, First-in-Human Phase 1 Trial.
Clin Pharmacol Drug Dev
; 11(5): 654-665, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35019238
12.
Development and SAR of functionally selective allosteric modulators of GABAA receptors.
Bioorg Med Chem
; 19(9): 2927-38, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21498079
13.
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism.
Nat Commun
; 7: 11671, 2016 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27216573
14.
A strategy to reduce biliary clearance in early drug discovery.
J Pharmacol Toxicol Methods
; 68(3): 346-8, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23518065
15.
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Bioorg Med Chem Lett
; 17(7): 1865-70, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17276676
16.
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Bioorg Med Chem Lett
; 14(17): 4453-9, 2004 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15357971
17.
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Drug Metab Dispos
; 31(4): 421-31, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12642468
18.
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Bioorg Med Chem Lett
; 13(24): 4299-304, 2003 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14643313
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