RESUMEN
Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Niños was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women (n = 1,519) during February 2017-September 2018 and their infants (n = 1,080) during June 2017-March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3-7.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7-2.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.
RESUMEN
La leptospirosis es una enfermedad ampliamente prevalente en áreas tropicales, pero también se presenta en áreas urbanas. El presente estudio tiene como objetivo determinar la seroprevalencia para Leptospira en el distrito de Puente Piedra, donde se han presentado casos de leptospirosis severa en los últimos años. Se recolectaron datos relacionados a factores de riesgo asociados con leptospirosis y muestras de sangre de 250 participantes, seleccionados por un muestreo aleatorio. Se encontró una alta prevalencia de factores de riesgo en la población y, usando la prueba de aglutinación microscópica, anticuerpos circulantes contra Leptospira en solamente tres participantes (1,2 por ciento).
Leptospirosis is a disease widely prevalent in tropical areas, but may also be present in urban areas. The present study aims to determine the seroprevalence of Leptospira in the district of Puente Piedra, where there have been cases of severe leptospirosis in recent years. We collected data related to risk factors associated with leptospirosis and blood samples from 250 participants, selected by random sampling. We found a high prevalence of risk factors in the population and using the microscopic agglutination test, antibodies were found in only 3 participants (1.2 percent).