Detalles de la búsqueda
1.
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling.
Arch Toxicol
; 2024 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38755481
2.
Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs).
Arch Toxicol
; 98(2): 551-565, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38085275
3.
Connecting Gut Microbial Diversity with Plasma Metabolome and Fecal Bile Acid Changes Induced by the Antibiotics Tobramycin and Colistin Sulfate.
Chem Res Toxicol
; 36(4): 598-616, 2023 04 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36972423
4.
Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans.
Environ Sci Technol
; 57(30): 10974-10984, 2023 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37478462
5.
Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation.
Environ Sci Technol
; 57(49): 20521-20531, 2023 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38008925
6.
Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays.
Arch Toxicol
; 97(6): 1547-1575, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37087486
7.
The role of receptor-mediated activities of 4- and 5-ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in developmental toxicity.
J Appl Toxicol
; 43(6): 845-861, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36585251
8.
In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans.
Arch Toxicol
; 96(8): 2361-2380, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35604418
9.
Population pharmacokinetic model to generate mechanistic insights in bile acid homeostasis and drug-induced cholestasis.
Arch Toxicol
; 96(10): 2717-2730, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35876888
10.
Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input.
Arch Toxicol
; 96(5): 1387-1409, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35294598
11.
Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent.
Arch Toxicol
; 96(1): 135-151, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34669010
12.
Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells.
Arch Toxicol
; 96(5): 1473-1482, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35224661
13.
The effect of alkyl substitution on the oxidative metabolism and mutagenicity of phenanthrene.
Arch Toxicol
; 96(4): 1109-1131, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35182162
14.
In vitro models to detect in vivo bile acid changes induced by antibiotics.
Arch Toxicol
; 96(12): 3291-3303, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36074177
15.
The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment.
Arch Toxicol
; 96(5): 1297-1352, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35249149
16.
The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides.
Planta Med
; 88(2): 130-143, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34741297
17.
Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment-A Workshop Report.
Planta Med
; 88(2): 98-117, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34715696
18.
Novel advances in biotransformation and bioactivation research - 2020 year in review.
Drug Metab Rev
; 53(3): 384-433, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33910427
19.
Risk characterisation of constituents present in jamu to promote its safe use.
Crit Rev Toxicol
; 51(2): 183-191, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34032188
20.
Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17ß glucuronide.
Arch Toxicol
; 95(1): 91-102, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33159584