RESUMEN
OBJECTIVE: We describe the clinical presentation and ocular viral dynamics in patients with Monkeypox virus-related ophthalmic disease (MPXROD). METHODS: In this case series, we investigated five consecutive patients with confirmed mpox, diagnosed through a positive Monkeypox virus (MPXV) Polymerase Chain Reaction (PCR) test and presenting with ocular symptoms. They were referred from the Reference Center for Sexually Transmitted Infections in São Paulo (CRT) to the Uveitis Sector at the Federal University of São Paulo, between August and December 2022. We performed PCR testing on ocular samples and culture supernatants for MPXV in all patients. Viral sequencing was conducted in one of the cases. RESULTS: Replicating MPXV was identified in at least one ocular sample of all patients, between day 31 and day 145 after the onset of skin lesions. All patients presented with keratitis, 3 with uveitis (60%) and two exhibited hypopyon (40%). The onset of ocular symptoms occurred at a mean of 21.2 days after the appearance of the first skin lesion and persisted, on average, for 61,.6 days, with a worsening trend observed until the initiation of tecovirimat treatment. Tecovirimat treatment was administered to all patients, with initiation occurring between 31 and 145 days after the onset of skin lesions. MPXV genome sequencing of an isolate from one patient classified it as belonging to lineage B1 in clade IIb. CONCLUSION: This study reveals a late onset and persistence of sight threatening ocular disease, along with potential viral infectivity even after systemic resolution in mpox cases. These findings highlight the risk of ongoing transmission from individuals with prolonged ocular manifestations, particularly through ocular discharge.
Asunto(s)
Monkeypox virus , Mpox , Humanos , Masculino , Femenino , Adulto , Mpox/virología , Mpox/diagnóstico , Monkeypox virus/genética , Monkeypox virus/aislamiento & purificación , Persona de Mediana Edad , Uveítis/virología , Uveítis/diagnóstico , Uveítis/tratamiento farmacológico , Queratitis/virología , Queratitis/diagnóstico , Queratitis/tratamiento farmacológico , Infecciones Virales del Ojo/virología , Infecciones Virales del Ojo/diagnóstico , Infecciones Virales del Ojo/tratamiento farmacológico , Ojo/virología , Antivirales/uso terapéuticoRESUMEN
Os autores apresentam um caso de coroidopatia geográfica típica, abordando principalmente as suas características clínicas e sua história natural
Asunto(s)
Humanos , Femenino , Adulto , Coriorretinitis/fisiopatología , Coroiditis/fisiopatología , Diagnóstico DiferencialRESUMEN
Tentou-se evidenciar, a importância da ecografia para o diagnóstico no tratamento da membrana neovascular sub-retiniana subsequente
Asunto(s)
Humanos , Masculino , Adulto , Neoplasias de la Coroides , Rayos Láser/uso terapéutico , Osteoma/diagnósticoRESUMEN
Foram examinados 40 prematuros consecutivos que nasceram no Hospital São Paulo no período de janeiro a dezembro de 1996, tendo sido realizados exames de fundo de olho, de motilidade extrínseca e Teller Acuity Cards. Nenhuma criança apresentou fator preditivo para ambliopia.