Detalles de la búsqueda
1.
Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.
Bioorg Med Chem Lett
; 19(10): 2693-8, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19362470
2.
Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.
Biochemistry
; 47(37): 9811-24, 2008 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-18717598
3.
Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
J Am Chem Soc
; 129(49): 15279-94, 2007 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-17999504
4.
Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.
J Med Chem
; 50(8): 1723-6, 2007 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17378545
5.
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.
J Med Chem
; 50(24): 5976-83, 2007 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17985858
6.
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.
J Med Chem
; 50(14): 3163-6, 2007 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-17552510
7.
Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase.
Org Lett
; 9(1): 9-12, 2007 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17192072
8.
Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.
J Med Chem
; 49(5): 1585-96, 2006 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-16509576
9.
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
J Med Chem
; 49(12): 3432-5, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16759082
10.
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
J Med Chem
; 49(21): 6139-42, 2006 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17034116
11.
Cyclization strategies in peptide derived drug design.
Curr Top Med Chem
; 2(3): 325-41, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11944823
12.
Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.
J Med Chem
; 47(17): 4147-50, 2004 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-15293984
13.
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
J Med Chem
; 47(10): 2430-40, 2004 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15115387
14.
Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.
J Med Chem
; 47(21): 4989-97, 2004 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15456243
15.
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Biochem Pharmacol
; 66(1): 93-103, 2003 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12818369
16.
Concise and enantioselective synthesis of Fmoc-Pmp(But)2-OH and design of potent Pmp-containing Grb2-SH2 domain antagonists.
Org Lett
; 5(17): 3095-8, 2003 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-12916990
17.
A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.
Assay Drug Dev Technol
; 9(4): 382-93, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21395401
18.
Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.
Anal Biochem
; 374(1): 87-98, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18023397
19.
Design and synthesis of paclitaxel conjugated with an ErbB2-recognizing peptide, EC-1.
Biopolymers
; 87(4): 225-30, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17879382
20.
Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid.
J Org Chem
; 71(19): 7307-14, 2006 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16958524