Psoriasiform exfoliative erythroderma induced by golimumab.

Golimumab is a fully human anti-tumour necrosis factor (TNF)-α monoclonal antibody approved for use in the treatment of active rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Psoriasis induced by treatment with anti-TNF drugs is well documented, but to our knowledge, the development of clinical features of psoriasiform exfoliative erythroderma during treatment with golimumab has not been previously described.

Verrucous carcinoma of the foot affecting the bone: utility of the computed tomography scanner.

Verrucous Carcinoma (VC) of the foot often affects deep structures such as tendons, muscles or bone. The complete removal of the tumor is essential to avoid recurrences. Radiological studies should be performed before surgical planning in order to determine the extent of the tumor. A 54-year-old man presented with a VC of the foot. Magnetic resonance imaging (MRI) demonstrated a soft-tissue mass affecting the plantar aponeurosis and the sole muscles, without evidence of bone invasion. Computed tomography (CT) showed a lytic area with cortical disruption in the fourth metatarsal neck. A transmetatarsal amputation was performed. Histopathological examination confirmed the bone invasion. MRI is considered the imaging technique of choice in studying VC of the foot. Computed tomography is superior to MRI in determining minimum changes in the cortical bone related to tumor invasion. We conclude that when MRI images are not conclusive, CT scan is a good alternative to determine incipient bone invasion.

Sign of Leser-Trélat associated with adenocarcinoma of the rectum.

The acute onset and/or rapid increase in size and number of multiple seborrheic keratoses associated with internal malignancy is called sign of Leser-Trélat. Although some authors reject its existence, there are more than 80 well-documented case reports in the literature. Here, we report a 75-year-old man who presented with abrupt appearance of multiple seborrheic keratoses without any suspicious symptom of cancer. The screening for malignant neoplasms let us detect a rectal adenocarcinoma that was in a curative stage. This case-report illustrates a true sign of Leser-Trélat, and proves that these patients must be appropriately investigated for underlying malignancy.

[Syphilis: current therapeutic perspectives]. / Sífilis: perspectivas terapéuticas actuales.

Despite many years of study questions regarding the appropriate therapy for syphilis still remain. Alternatives to penicillin for the treatment of syphilis continue to be sought. This article examines the studies relating to syphilis treatment published during the last years and also the new treatment guidelines for every stage of this sexually transmitted disease.

[Spitz's nevus: clinicopathologic study of 25 cases]. / Nevus de Spitz: estudio clinicopatológico de 25 casos.

We reviewed the clinical and histopathologic findings in 25 Spitz's nevus who were evaluated at our institution from 1980-1988. 18 cases in patients aged 20 years or less and 7 cases in adults. 14 are female and 11 are male. Represent the 3.88% of melanocytic nevi etude in the same time. Eosinophilic globules were find in 64% of the cases. We include a pigmented spindle cell nevi (non-Spitz), we thinks is a variant of Spitz's nevus.

[Erysipelas and cellulitis: a retrospective study of 122 cases]. / Erisipelas y celulitis. Estudio retrospectivo de 122 casos.

BACKGROUND: Erysipelas and cellulitis are relatively common cutaneous infections that can sometimes be the cause of a prolonged hospital admission. The objective of this study was to determine the most relevant epidemiologic factors and their influence on the length of hospital stay, comparing our results with those of previous studies. MATERIAL AND METHODS: We performed a retrospective, observational, cross-sectional study of 122 patients admitted over a 5-year period to the dermatology department of our hospital with a diagnosis of erysipelas or cellulitis. RESULTS: Patients with a diagnosis of erysipelas or cellulitis represented 8.6% of all admissions during the study period. The mean age was 58.93 years and the female to male ratio was 1.06:1. The most common site of involvement was on the legs (76.22%). Overweight or obesity was present in 42.6% of patients and tinea pedis was detected in 33.6% of cases. A skin abscess developed in 7.4% of cases. The mean length of admission was 10.20 days; length of stay increased with age and with the erythrocyte sedimentation rate (ESR) on admission (P < .01 for both differences). CONCLUSIONS: We confirm general epidemiologic factors such as sex and age distributions, predominant site, past history, and length of hospital stay. In view of their predictive value for the length of hospital stay, we propose that age and the ESR on admission should be considered to be indirect indicators of disease severity.

[Our experience with infliximab in reclacitrant cases of psoriasis]. / Nuestra experiencia con infliximab en psoriasis recalcitrante.

Present report is focused in our personal experience with the anti TNF-alpha infliximab. There is a short, four case series, but they are a very representative sample of the clinical conditions that we can solve with infliximab.