RESUMEN
The prevalence of people in Denmark descending from areas with a high prevalence of haemoglobinopathies is approximately one tenth and increasing. Since 1995, the Danish Health Authority has recommended haemoglobinopathy screening of pregnant women with ethnic roots outside Northern Europe. Partners of pregnant haemoglobinopathy carriers are also tested. Carrier state in both parents leads to genetic counselling, and prenatal diagnostics of the foetus (chorionic villus biopsy or amniocentesis) is offered, which can lead to abortion and/or preimplantation genetic screening for future pregnancies, as discussed in this review.
Asunto(s)
Amniocentesis , Hemoglobinopatías , Dinamarca/epidemiología , Europa (Continente) , Femenino , Hemoglobinopatías/diagnóstico , Hemoglobinopatías/epidemiología , Humanos , Embarazo , Diagnóstico PrenatalRESUMEN
Sickle cell disease (SCD) is the most common severe hereditary disease worldwide. SCD during pregnancy is associated with increased incidence of perinatal mortality, premature labour, foetal growth restriction, and acute painful crises. Global migration has contributed to a greater geographical spread of individuals with hereditary haemoglobinopathies. This has led to an increased incidence of pregnant women with SCD in Denmark. In this review, we descibe the aetiology, assessment, antenatal care and treatment of pregnant women with SCD.
Asunto(s)
Anemia de Células Falciformes , Complicaciones Hematológicas del Embarazo , Anemia de Células Falciformes/epidemiología , Anemia de Células Falciformes/terapia , Femenino , Retardo del Crecimiento Fetal/epidemiología , Humanos , Incidencia , Embarazo , Complicaciones Hematológicas del Embarazo/epidemiología , Complicaciones Hematológicas del Embarazo/terapia , Resultado del EmbarazoAsunto(s)
Anticonceptivos Orales Combinados/efectos adversos , Anticonceptivos Sintéticos Orales/efectos adversos , Infarto del Miocardio/inducido químicamente , Adulto , Factores de Edad , Anticonceptivos Orales Combinados/administración & dosificación , Anticonceptivos Sintéticos Orales/administración & dosificación , Congéneres del Estradiol/administración & dosificación , Femenino , Humanos , Congéneres de la Progesterona/administración & dosificación , Factores de RiesgoAsunto(s)
Cesárea/métodos , Síndrome HELLP/diagnóstico , Hematoma/diagnóstico , Hepatopatías/diagnóstico , Hemorragia Posoperatoria/cirugía , Preeclampsia/cirugía , Adulto , Cesárea/efectos adversos , Femenino , Estudios de Seguimiento , Síndrome HELLP/terapia , Hematoma/terapia , Humanos , Laparotomía/métodos , Hepatopatías/terapia , Monitoreo Fisiológico , Hemorragia Posoperatoria/diagnóstico , Periodo Posparto , Preeclampsia/diagnóstico , Embarazo , Enfermedades Raras , Reoperación/métodos , Tomografía Computarizada por Rayos X/métodos , Ultrasonografía Doppler/métodosRESUMEN
PURPOSE: Principal blood flow measures might be assessable by velocity-encoded cine magnetic resonance (VENC MR) of aortic blood flow. The feasibility of using VENC MR for clinical research was tested in a contemporary and controversial human model: the effects of 17beta-estradiol (E) and cyclic norethisterone acetate (NETA) in postmenopausal women. METHODS: Sixteen postmenopausal women were included in a crossover study (two 12-week periods, 3-month washout) and randomized to E and NETA or placebo. Aortic blood flow (ABF) was measured eight times by VENC MR below and above the coronary arteries (CA) and was used for estimation of coronary artery blood flow (CABF) and peak flow velocity (Vmax). The calculated value of CABF was negative and was corrected by averaging systolic flow. Data were analyzed in a repeated measurement model including analysis of repeatability (CR) and group variability (CV). RESULTS: The CR and CV of ABF were low (11% and 7%) and corresponded at the two levels. Vmax showed similar levels of reproducibility at the two levels. The coronary artery blood flow was less reproducible (39% and 31%). During treatment, ABF above CA was reduced after 12 weeks (p=0.03), ABF below CA was unchanged, and CABF was significantly increased without detrimental effects of NETA. Vmax was increased at NETA addition (p<0.01). CONCLUSIONS: Aortic flow quantification by VENC MR is reproducible and useful for assessment of principal haemodynamic changes in smaller studies. Derived measurement of CABF lacks precision. Differences in change below and above CA indicate that oral high-dose E and NETA may induce coronary artery dilatation.