Detalles de la búsqueda
1.
Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species.
Xenobiotica
; : 1-13, 2024 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38647387
2.
Multiplexed Quantitative Analysis of Antibody-Drug Conjugates with Labile CBI-Dimer Payloads In Vivo Using Immunoaffinity LC-MS/MS.
Anal Chem
; 94(2): 1158-1168, 2022 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34958550
3.
Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates.
Anal Chem
; 92(18): 12168-12175, 2020 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32786429
4.
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.
Drug Metab Dispos
; 48(11): 1161-1168, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32839277
5.
A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30910894
6.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30966735
7.
Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte.
Anal Bioanal Chem
; 411(12): 2587-2596, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30828756
8.
Platform model describing pharmacokinetic properties of vc-MMAE antibody-drug conjugates.
J Pharmacokinet Pharmacodyn
; 44(6): 537-548, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28918591
9.
Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys.
Pharm Res
; 32(6): 1907-19, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25467958
10.
The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results.
Nat Commun
; 15(1): 466, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38212321
11.
Preclinical safety profile of trastuzumab emtansine (T-DM1): mechanism of action of its cytotoxic component retained with improved tolerability.
Toxicol Appl Pharmacol
; 273(2): 298-313, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24035823
12.
Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development.
Front Immunol
; 14: 1295285, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38022649
13.
2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 15(16): 955-1016, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37650500
14.
Percutaneous Renal Biopsy in Egyptian Children: A Five-year Single-Center Experience.
Saudi J Kidney Dis Transpl
; 33(1): 106-110, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36647984
15.
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
Bioconjug Chem
; 22(10): 1994-2004, 2011 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-21913715
16.
Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry.
Anal Biochem
; 412(1): 56-66, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21216214
17.
Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY®) Antibody-Drug Conjugate in Sprague Dawley Rats.
J Clin Med
; 10(6)2021 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33806916
18.
Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1.
Mol Cancer Res
; 18(4): 644-656, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31900313
19.
Immunogenicity of antibody-drug conjugates: observations across 8 molecules in 11 clinical trials.
Bioanalysis
; 11(17): 1555-1568, 2019 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-31208199
20.
Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus.
MAbs
; 11(6): 1162-1174, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31219754