Dextran-coated iron oxide nanoparticles in combination with ginger extract without NGF promote neurite outgrowth and PC12 cell branching.

Neurogenesis is decreased in the absence of nerve growth factor (NGF). It would be beneficial to discover substances that stimulate neurogenesis without NGF, given the high molecular weight and brief half-life of NGF. This work aims to assess the neurogenesis of ginger extract (GE) combined with superparamagnetic iron oxide nanoparticles (SPIONs) without NGF. Based on our research, GE and SPIONs start neurogenesis before NGF. In comparison to the control group, GE and SPIONs dramatically reduced the length and quantity of neurites, according to statistical analysis. Our findings also indicated that SPIONs and ginger extract together had an additive impact on one another. The total number significantly increased with the addition of GE and nanoparticles. In comparison to NGF, the mixture of GE and nanoparticles significantly enhanced the total number of cells with neurites (by about 1.2-fold), the number of branching points (by about 1.8-fold), and the length of neurites. The difference between ginger extract and nanoparticles with NGF was significant (about 3.5-fold), particularly in the case of cells with one neurite. The results of this study point to the possibility of treating neurodegenerative disorders via the combination of GE and SPIONs without NGF.

Fabrication of Injectable Micro-Scale Opto-Electronically Transduced Electrodes (MOTEs) for Physiological Monitoring.

In vivo, chronic neural recording is critical to understand the nervous system, while a tetherless, miniaturized recording unit can render such recording minimally invasive. We present a tetherless, injectable micro-scale opto-electronically transduced electrode (MOTE) that is ~60µm × 30µm × 330µm, the smallest neural recording unit to date. The MOTE consists of an AlGaAs micro-scale light emitting diode (µLED) heterogeneously integrated on top of conventional 180nm complementary metal-oxide-semiconductor (CMOS) circuit. The MOTE combines the merits of optics (AlGaAs µLED for power and data uplink), and of electronics (CMOS for signal amplification and encoding). The optical powering and communication enable the extreme scaling while the electrical circuits provide a high temporal resolution (<100µs). This paper elaborates on the heterogeneous integration in MOTEs, a topic that has been touted without much demonstration on feasibility or scalability. Based on photolithography, we demonstrate how to build heterogenous systems that are scalable as well as biologically stable - the MOTEs can function in saline water for more than six months, and in a mouse brain for two months (and counting). We also present handling/insertion techniques for users (i.e. biologists) to deploy MOTEs with little or no extra training.

Applications of wireless sensor networks to improve occupational safety and health in underground mines.

INTRODUCTION: The very complex and hazardous environment of underground mines may significantly contribute to occupational fatalities and injuries. Deploying wireless sensor network (WSN) technology has the potential to improve safety and health monitoring of miners and operators. However, the application of WSN in the industry is not fully understood and current research themes in this area are fragmented. Thus, there is a need for a comprehensive review that directly explores the contribution of WSNs to occupational safety and health (OSH) in underground mines. METHOD: This study aims to conduct a systematic literature review on the existing applications of WSNs for improving OSH in the underground mining industry to pinpoint innovative research themes and their main achievements, reveal gaps and shortcomings in the literature, recommend avenues for future scholarly works, and propose potential safety interventions. The major contribution of this review is to provide researchers and practitioners with a holistic understanding of the integration of WSN applications into underground mine safety and health management. RESULTS: The review results have been categorized and discussed under three predominant categories including location monitoring and tracking, physiological and body kinematics monitoring, and environmental monitoring. Finally, seven major directions for future research and practical interventions have been identified based on the existing research gaps including: (1) further applications of WSNs for underground mining OSH management; (2) application of WSNs from research to real-world practice; (3) big data analytics and management; (4) deploying multiple WSNs-based monitoring systems; (5) integration of WSNs with other communication systems; (6) adapting WSNs to the Internet of Things (IoT) infrastructure; and (7) autonomous WSNs.