Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 26
Filtrar
Más filtros

Banco de datos
Tipo del documento
Intervalo de año de publicación
1.
Inhal Toxicol ; 36(6): 391-405, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38952303

RESUMEN

OBJECTIVES: To evaluate potential airborne asbestos exposures during brake maintenance and repair activities on a P&H overhead crane, and during subsequent handling of the mechanic's clothing. METHODS: Personal (n = 27) and area (n = 61) airborne fiber concentrations were measured during brake tests, removal, hand sanding, compressed air use, removal and reattachment of chrysotile-containing brake linings, and reinstallation of the brake linings. The mechanic's clothing was used to measure potential exposure during clothes handling. RESULTS: All brake linings contained between 19.9% to 52.4% chrysotile asbestos. No amphibole fibers were detected in any bulk or airborne samples. The average full-shift airborne chrysotile concentration was 0.035 f/cc (PCM-equivalent asbestos-specific fibers, or PCME). Average task-based personal air samples collected during brake maintenance, sanding, compressed air use, and brake lining removal tasks ranged from 0 to 0.48 f/cc (PCME). The calculated 30-minute time-weighted average (TWA) airborne chrysotile concentration associated with 5-15 minutes of clothes handling was 0-0.035 f/cc PCME. CONCLUSION: The results indicated that personal and area TWA fiber concentrations measured during all crane brake maintenance and clothes handling tasks were below the current OSHA 8-h TWA Permissible Exposure Limit for asbestos of 0.1 f/cc. Further, no airborne asbestos fibers were measured during routine brake maintenance tasks following the manufacturer's maintenance manual procedures. All short-term airborne chrysotile concentrations measured during non-routine tasks were below the current 30-minute OSHA excursion limit for asbestos of 1 f/cc. This study adds to the available data regarding chrysotile exposure potential during maintenance on overhead cranes.


Asunto(s)
Contaminantes Ocupacionales del Aire , Asbestos Serpentinas , Exposición Profesional , Exposición Profesional/análisis , Contaminantes Ocupacionales del Aire/análisis , Humanos , Asbestos Serpentinas/análisis , Mantenimiento , Exposición por Inhalación/análisis , Monitoreo del Ambiente/métodos , Automóviles , Amianto/análisis
2.
J Occup Environ Hyg ; 20(3-4): 143-158, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36716165

RESUMEN

The accuracy of exposure judgments, particularly for scenarios where only qualitative information is available or a systematic approach is not used, has been evaluated and shown to have a relatively low level of accuracy. This is particularly true for dermal exposures, where less information is generally available compared to inhalation exposures. Relatively few quantitative validation efforts have been performed for scenarios where dermal exposures are of interest. In this study, a series of dermal exposure judgments were collected from 90 volunteer U.S. occupational health practitioners in a workshop format to assess the accuracy of their judgments for three specific scenarios. Accuracy was defined as the ability of the participants to identify the correct reference exposure category, as defined by the quantitative exposure banding categories utilized by the American Industrial Hygiene Association (AIHA®). The participants received progressively additional information and training regarding dermal exposure assessments and scenario-specific information during the workshop, and the relative accuracy of their category judgments over time was compared. The results of the study indicated that despite substantial education and training in exposure assessment generally, the practitioners had very little experience in performing dermal exposure assessments and a low level of comfort in performing these assessments. Further, contrary to studies of practitioners performing inhalation exposure assessments demonstrating a trend toward underestimating exposures, participants in this study consistently overestimated the potential for dermal exposure without quantitative data specific to the scenario of interest. Finally, it was found that participants were able to identify the reference or "true" category of dermal exposure acceptability when provided with relevant, scenario-specific dermal and/or surface-loading data for use in the assessment process. These results support the need for additional training and education of practitioners in performing dermal exposure assessments. A closer analysis of default loading values used in dermal exposure assessments to evaluate their accuracy relative to real-world or measured dermal loading values, along with consistent improvements in current dermal models, is also needed.


Asunto(s)
Exposición Profesional , Salud Laboral , Humanos , Exposición Profesional/análisis , Juicio , Medición de Riesgo/métodos , Salud Laboral/educación , Exposición por Inhalación
3.
Risk Anal ; 39(10): 2272-2294, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-30980426

RESUMEN

Over time, concerns have been raised regarding the potential for human exposure and risk from asbestos in cosmetic-talc-containing consumer products. In 1985, the U.S. Food and Drug Administration (FDA) conducted a risk assessment evaluating the potential inhalation asbestos exposure associated with the cosmetic talc consumer use scenario of powdering an infant during diapering, and found that risks were below levels associated with background asbestos exposures and risk. However, given the scope and age of the FDA's assessment, it was unknown whether the agency's conclusions remained relevant to current risk assessment practices, talc application scenarios, and exposure data. This analysis updates the previous FDA assessment by incorporating the current published exposure literature associated with consumer use of talcum powder and using the current U.S. Environmental Protection Agency's (EPA) nonoccupational asbestos risk assessment approach to estimate potential cumulative asbestos exposure and risk for four use scenarios: (1) infant exposure during diapering; (2) adult exposure from infant diapering; (3) adult exposure from face powdering; and (4) adult exposure from body powdering. The estimated range of cumulative asbestos exposure potential for all scenarios (assuming an asbestos content of 0.1%) ranged from 0.0000021 to 0.0096 f/cc-yr and resulted in risk estimates that were within or below EPA's acceptable target risk levels. Consistent with the original FDA findings, exposure and corresponding health risk in this range were orders of magnitude below upper-bound estimates of cumulative asbestos exposure and risk at ambient levels, which have not been associated with increased incidence of asbestos-related disease.


Asunto(s)
Contaminantes Atmosféricos/toxicidad , Amianto/toxicidad , Exposición a Riesgos Ambientales , Polvos , Medición de Riesgo , Talco/toxicidad , Humanos , Factores de Riesgo
4.
Risk Anal ; 38(3): 454-471, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-28863229

RESUMEN

Over the past 40 years, measured ambient asbestos concentrations in the United States have been higher in urban versus rural areas. The purpose of this study was to determine whether variations in ambient asbestos concentrations have influenced pleural mesothelioma risk in females (who generally lacked historic occupational asbestos exposure relative to males). Male pleural mesothelioma incidence trends were analyzed to provide perspective for female trends. Annual age-adjusted incidence rates from 1973 to 2012 were obtained from the SEER 9, 13, and 18 databases for urban and rural locations, and standardized rate ratios were calculated. Female rural rates exceeded urban rates in almost half of the years analyzed, although the increases were not statistically significant, which is in line with expectations if there was no observable increased risk for urban locations. In contrast, male urban rates were elevated over rural rates for nearly all years examined and were statistically significantly elevated for 22 of the 40 years. Trend analyses demonstrated that trends for females remained relatively constant over time, whereas male urban and rural incidence increased into the 1980s and 1990s, followed by a decrease/leveling off. Annual female urban and rural incidence rates remained approximately five- to six-fold lower than male urban and rural incidence rates on average, consistent with the comparatively increased historical occupational asbestos exposure for males. The results suggest that differences in ambient asbestos concentrations, which have been reported to be 10-fold or greater across regions in the United States, have not influenced the risk of pleural mesothelioma.


Asunto(s)
Amianto/efectos adversos , Neoplasias Pulmonares/inducido químicamente , Neoplasias Pulmonares/epidemiología , Mesotelioma/inducido químicamente , Mesotelioma/epidemiología , Neoplasias Pleurales/inducido químicamente , Neoplasias Pleurales/epidemiología , Factores de Edad , Femenino , Humanos , Incidencia , Masculino , Mesotelioma Maligno , Exposición Profesional/efectos adversos , Sistema de Registros , Población Rural , Programa de VERF , Factores Sexuales , Estados Unidos , Población Urbana
5.
Crit Rev Toxicol ; 47(4): 286-316, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-28328293

RESUMEN

The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbestos and its health risks, from the early 1900s until the advent of the national occupational health and safety regulatory structure currently in place in the US (early-to-mid 1970s) is presented. While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health hazard, it was not until the mid-1950s that the carcinogenic nature of asbestos began to be characterized and widespread concern followed. With the introduction of the membrane filter sampling method in the late 1960s and early 1970s, asbestos sampling and exposure assessment capabilities advanced to a degree which allowed industrial hygienists to more precisely characterize the exposure-response relationship. The ability of industrial hygienists, analytical chemists, toxicologists, and physicians to more accurately define this relationship was instrumental to the scientific community's ability to establish Occupational Exposure Levels (OELs) for asbestos. These early developments set the stage for decades of additional study on asbestos exposure potential and risk of disease. This was followed by the application of engineering controls and improved respiratory protection which, over the years, saved thousands of lives. This paper represents a state-of-the-art review of the knowledge of asbestos within the industrial hygiene community from about 1900 to 1975.


Asunto(s)
Contaminantes Ocupacionales del Aire/análisis , Amianto/análisis , Asbestosis/epidemiología , Exposición Profesional/estadística & datos numéricos , Salud Laboral , Exposición por Inhalación , Exposición Profesional/análisis
6.
Ann Occup Hyg ; 59(2): 210-20, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25367654

RESUMEN

There are currently no published empirical data that characterize hand-to-mouth transfer efficiencies for metallic lead. The purpose of this study was to quantify the hand-to-mouth transfer efficiency of lead in adult volunteers (n = 6) using human saliva as a surrogate for the mouth and commercially available, 100% lead fishing weights as the source of lead for dermal loading. Study volunteers' saliva was collected and subsequently poured onto a sheet of wax paper placed on a balance scale. The volunteers handled lead fishing weights with both hands for approximately 15 s and then pressed three fingers from the right hand (test hand) into their saliva 10 times, with ~0.45kg of pressure. The left hand (control hand) was used as a comparison for dermal loading of lead and had no contact with saliva. SKC Full Disclosure® wipes were used to collect lead from the saliva and skin surfaces. Samples were analyzed using the NIOSH 7300 method, which was modified for wipes. The mean lead skin-to-saliva transfer efficiency was 24% (range: 12-34%). These data will be useful for more accurately characterizing lead hand-to-mouth transfer efficiencies and are likely to be helpful in exposure assessments or human health risk assessments.


Asunto(s)
Exposición a Riesgos Ambientales/análisis , Mano , Plomo , Boca , Monitoreo del Ambiente/métodos , Humanos , Plomo/farmacocinética , Medición de Riesgo , Absorción Cutánea
7.
Regul Toxicol Pharmacol ; 72(3): 615-29, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25985714

RESUMEN

The United States Occupational Safety and Health Administration (OSHA) maintains the Chemical Exposure Health Data (CEHD) and the Integrated Management Information System (IMIS) databases, which contain quantitative and qualitative data resulting from compliance inspections conducted from 1984 to 2011. This analysis aimed to evaluate trends in workplace asbestos concentrations over time and across industries by combining the samples from these two databases. From 1984 to 2011, personal air samples ranged from 0.001 to 175 f/cc. Asbestos compliance sampling data associated with the construction, automotive repair, manufacturing, and chemical/petroleum/rubber industries included measurements in excess of 10 f/cc, and were above the permissible exposure limit from 2001 to 2011. The utility of combining the databases was limited by the completeness and accuracy of the data recorded. In this analysis, 40% of the data overlapped between the two databases. Other limitations included sampling bias associated with compliance sampling and errors occurring from user-entered data. A clear decreasing trend in both airborne fiber concentrations and the numbers of asbestos samples collected parallels historically decreasing trends in the consumption of asbestos, and declining mesothelioma incidence rates. Although air sampling data indicated that airborne fiber exposure potential was high (>10 f/cc for short and long-term samples) in some industries (e.g., construction, manufacturing), airborne concentrations have significantly declined over the past 30 years. Recommendations for improving the existing exposure OSHA databases are provided.


Asunto(s)
Contaminantes Ocupacionales del Aire/análisis , Amianto/análisis , Exposición Profesional/análisis , United States Occupational Safety and Health Administration/normas , Lugar de Trabajo/normas , Agricultura , Contaminantes Ocupacionales del Aire/historia , Contaminantes Ocupacionales del Aire/normas , Amianto/historia , Amianto/normas , Bases de Datos Factuales , Monitoreo del Ambiente , Historia del Siglo XX , Historia del Siglo XXI , Industrias , Exposición Profesional/historia , Exposición Profesional/normas , Transportes , Estados Unidos
8.
Ann Occup Hyg ; 58(9): 1079-93, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25169203

RESUMEN

A hierarchical Bayesian framework has been developed for exposure assessment that makes use of statistical sampling-based techniques to estimate the posterior probability of the 95th percentile or arithmetic mean of the exposure distribution being located in one of several exposure categories. The framework can synthesize professional judgment and monitoring data to yield an updated posterior exposure assignment for routine exposure management. The framework is versatile enough that it can be modified for use in epidemiological studies for classifying the arithmetic mean instead of the 95th percentile into several exposure categories. Various physico-chemical exposure models have also been incorporated in the hierarchical framework. The use of the framework in three settings has been illustrated. First, subjective judgments about exposure magnitude obtained from industrial hygienists for five tasks were treated as priors in the Bayesian framework. Monitoring data for each task were used to create a likelihood function in the hierarchical framework and the posterior was predicted in terms of the 95th percentile being located in each of the four AIHA exposure categories. The accuracy of the exposure judgments was then evaluated. Second, we illustrate the use of exposure models to develop priors in this framework and compare with monitoring data in an iron foundry. Finally, we illustrate the use of this approach for retrospective exposure assessment in a chemical manufacturing facility, to categorize exposures based on arithmetic mean instead of 95th percentile.


Asunto(s)
Técnicas de Apoyo para la Decisión , Higiene , Modelos Estadísticos , Exposición Profesional/análisis , Salud Laboral , Teorema de Bayes , Estudios Retrospectivos , Valores Limites del Umbral
9.
Risk Anal ; 39(12): 2604-2607, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31797415
11.
J Air Waste Manag Assoc ; 63(4): 424-32, 2013 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23687727

RESUMEN

UNLABELLED: Concerns have arisen among the public regarding the potentialfor drinking-water contamination from the migration of methane gas and hazardous chemicals associated with hydraulic fracturing and horizontal drilling. However, little attention has been paid to the potentialfor groundwater contamination resulting from surface spills from storage and production facilities at active well sites. We performed a search for publically available data regarding groundwater contamination from spills at ULS. drilling sites. The Colorado Oil and Gas Conservation Commission (COGCC) database was selected for further analysis because it was the most detailed. The majority ofspills were in Weld County, Colorado, which has the highest density of wells that used hydraulic fracturing for completion, many producing both methane gas and crude oil. We analyzed publically available data reported by operators to the COGCC regarding surface spills that impacted groundwater From July 2010 to July 2011, we noted 77 reported surface spills impacting the groundwater in Weld County, which resulted in surface spills associated with less than 0.5% of the active wells. The reported data included groundwater samples that were analyzed for benzene, toluene, ethylbenzene, andxylene (BTEX) components of crude oil. For groundwater samples taken both within the spill excavation area and on the first reported date of sampling, the BTEX measurements exceeded National Drinking Water maximum contaminant levels (MCLs) in 90, 30, 12, and 8% of the samples, respectively. However, actions taken to remediate the spills were effective at reducing BJTEX levels, with at least 84% of the spills reportedly achieving remediation as of May 2012. Our analysis demonstrates that surface spills are an important route of potential groundwater contamination from hydraulic fracturing activities and should be a focus of programs to protect groundwater IMPLICATIONS: While benzene can occur naturally in groundwater sources, spills and migration of chemicals used for hydraulic fracturing activities have recently been thought to be a main source of benzene contamination in groundwater. However, there is little scientific literature to support that claim. Therefore, we accessed a publically available database and tracked the number of reported surface spills with potential groundwater impact over a 1-year period. Although the number of surface spills was minimal, our analysis provides scientific evidence that benzene can contaminate groundwater sources following surface spills at active well sites.


Asunto(s)
Derivados del Benceno/química , Benceno/química , Agua Subterránea/química , Tolueno/química , Contaminantes Químicos del Agua/química , Xilenos/química , Monitoreo del Ambiente , Industria Procesadora y de Extracción , Residuos Industriales
12.
Ann Work Expo Health ; 66(7): 923-936, 2022 08 07.
Artículo en Inglés | MEDLINE | ID: mdl-35437588

RESUMEN

The factors influencing transfer of chemicals or other contaminants to and from the surface of the skin are often poorly understood. Previous research has indicated that environmental conditions, skin hydration, and repeated contacts may all influence the quantity of dermal transfer. The aim of this analysis was to evaluate the influence of skin hydration and condition on quantitative chemical transfer in a series of systematic measurements using human subjects for 5 and 10 repeated contacts. Elemental metallic lead was used as the exemplar test substance for the measurements collected. Skin hydration index (HI) was assessed using a corneometer and skin condition and barrier function were measured using an open-chamber transepidermal water loss (TEWL) instrument. Results indicated that for the palmar surface of the index finger where sampling was conducted, the relative hydration level of the skin was higher for males (n = 6) versus females (n = 4) (mean HI = 4.0 for females; mean HI = 5.5 for males) but this difference was not statistically significant. Overall, the skin hydration level was not significantly associated with dermal loading for either the 5 contact scenario (Pearson correlation = 0.27; R2 = 0.07; P = 0.45) or the 10 contact scenario (Pearson correlation = 0.26; R2 = 0.07; P = 0.47). When the results were stratified by higher versus lower hydration levels (HI = 1-5 versus HI = 5-10), for the higher hydration levels (HI = 5-10; mean HI = 7), there was a moderately positive association between skin hydration and loading, but this was not statistically significant for either the 5 contact scenario (Pearson correlation = 0.75; R2 = 0.56; P = 0.15) or the 10 contact scenario (Pearson correlation = 0.6; R2 = 0.36; P = 0.28). No clear relationship was observed between the lower hydration levels (HI = 1-5) and dermal loading. For the palmar index finger, there was a negative correlation between the TEWL measurements and both the 5 contact (Pearson correlation = -0.45; R2 = 0.2; P = 0.19) and 10 contact (Pearson correlation = -0.3; R2 = 0.09; P = 0.4) scenarios, but this was not statistically significant. The results of this study are consistent with the limited results of other analyses, which have suggested that there may be nuances with respect to the effects of skin hydration on the quantitative dermal transfer to and from the skin, although additional data are needed to better understand these potential differences.


Asunto(s)
Exposición Profesional , Pérdida Insensible de Agua , Femenino , Humanos , Masculino , Piel/química , Agua/análisis , Agua/metabolismo
13.
Crit Rev Toxicol ; 41(1): 52-74, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20854013

RESUMEN

This article presents a review of the publicly available information as it relates to airborne asbestos concentrations at varying distances from a source in an occupational environment. Personal and area samples collected 5-75 feet from the primary worker from workplace surveys conducted in the 1970s and area samples collected 5-50 feet from the primary worker during more recent simulation studies were identified, compiled, and analyzed. As expected, airborne asbestos concentrations generally decreased with distance from the worker who performed a given task. Based on this review, however, the authors found that no systematic research to quantitatively relate fiber concentration with distance from the source (including consideration of fiber length, dilution ventilation, and initial momentum of the particle) has been conducted to date. A simple mathematical model was therefore used, and the results were considered, along with available published data comparing exposure data for both workers and persons/areas near workers. From this analysis, the authors offer guidance for estimating airborne asbestos concentrations at distance from a source. Based on the available data and our modeling results, the authors propose the following approach as a rule of thumb: for persons 1-5 feet from the source, airborne asbestos concentrations can be roughly approximated at 50% of the source concentration; 35% at >5-10 feet, 10% for >10-30 feet, and less than 1% at distances greater than 30 feet. This approach should be helpful for bracketing the range of likely exposures to bystanders being evaluated in asbestos-related dose-reconstruction analyses.


Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Amianto/toxicidad , Exposición Profesional , Salud Laboral , Monitoreo del Ambiente , Humanos , Modelos Teóricos , Lugar de Trabajo
14.
Crit Rev Toxicol ; 41(2): 111-42, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21288163

RESUMEN

There is growing emphasis in the United States and Europe regarding the quantification of dermal exposures to chemical mixtures and other substances. In this paper, we determine the dermal flux of benzene in neat form, in organic solvents, and in aqueous solutions based on a critical review and analysis of the published literature, and discuss appropriate applications for using benzene dermal absorption data in occupational risk assessment. As part of this effort, we synthesize and analyze data for 77 experimental results taken from 16 studies of benzene skin absorption. We also assess the chemical activity of benzene in simple hydrocarbon solvent mixtures using a thermodynamic modeling software tool. Based on the collective human in vivo, human in vitro, and animal in vitro data sets, we find that the steady-state dermal flux for neat benzene (and benzene-saturated aqueous solutions) ranges from 0.2 to 0.4 mg/(cm²·h). Observed outlier values for some of the animal in vivo data sets are possibly due to the use of test species that have more permeable skin than humans or study conditions that resulted in damage to the skin barrier. Because relatively few dermal absorption studies have been conducted on benzene-containing organic solvents, and available test results may be influenced by study design or vehicle effects, it is not possible to use these data to quantify the dermal flux of benzene for other types of solvent mixtures. However, depending on the application, we describe several potential approaches that can be used to derive a rough approximation of the steady-state benzene dermal flux for these mixtures. Important limitations with respect to quantifying and evaluating the significance of dermal exposures to benzene in occupational settings include a lack of data on (1) factors that affect the dermal uptake of benzene, (2) the dermal flux of benzene for different organic solvent mixtures, (3) meaningful metrics for evaluating the dermal uptake of benzene, (4) steady-state versus non-steady-state dermal flux values for benzene, (5) the effect of skin damage on the dermal flux of benzene, (6) standardized test methods for estimating the dermal flux of benzene, and (7) robust estimates of the evaporation rate of benzene from different liquid vehicles.


Asunto(s)
Benceno/farmacocinética , Sustancias Peligrosas/farmacocinética , Enfermedades Profesionales/metabolismo , Exposición Profesional/efectos adversos , Salud Laboral , Absorción Cutánea , Animales , Benceno/toxicidad , Sustancias Peligrosas/toxicidad , Humanos , Enfermedades Profesionales/etiología , Reproducibilidad de los Resultados , Medición de Riesgo , Piel/efectos de los fármacos , Piel/metabolismo , Especificidad de la Especie
15.
Environ Sci Technol ; 45(17): 7372-9, 2011 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-21797246

RESUMEN

Concerns have been raised about whether the Deepwater Horizon oil spill cleanup workers experienced adverse health effects from exposure to airborne benzene, toluene, ethylbenzene, and xylene (BTEX) which volatilized from surfaced oil. Thus, we analyzed the nearly 20 000 BTEX measurements of breathing zone air samples of offshore cleanup workers taken during the six months following the incident (made publicly available by British Petroleum). The measurements indicate that 99% of the measurements taken prior to capping the well were 32-, 510-, 360-, and 77-fold lower than the U.S. Occupational Safety and Health Administration's Permissible Exposure Limits (PELs) for BTEX, respectively. BTEX measurements did not decrease appreciably during the three months after the well was capped. Moreover, the magnitudes of these data were similar to measurements from ships not involved in oil slick remediation, suggesting that the BTEX measurements were primarily due to engine exhaust rather than the oil slick. To supplement the data analysis, two modeling approaches were employed to estimate airborne BTEX concentrations under a variety of conditions (e.g., oil slick thickness, wind velocity). The modeling results corroborated that BTEX concentrations from the oil were well below PELs and that the oil was not the primary contributor to the measured BTEX.


Asunto(s)
Contaminantes Atmosféricos/análisis , Derivados del Benceno/análisis , Benceno/análisis , Modelos Teóricos , Contaminación por Petróleo/análisis , Tolueno/análisis , Xilenos/análisis , Exposición a Riesgos Ambientales , Monitoreo del Ambiente/métodos , Humanos , Exposición por Inhalación , Concentración Máxima Admisible , Método de Montecarlo , Exposición Profesional , Emisiones de Vehículos , Volatilización , Viento
16.
Crit Rev Toxicol ; 40(9): 799-843, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20722488

RESUMEN

Exposure reconstruction for substances of interest to human health is a process that has been used, with various levels of sophistication, as far back as the 1930s. The importance of robust and high-quality exposure reconstruction has been recognized by many researchers. It has been noted that misclassification of reconstructed exposures is relatively common and can result in potentially significant effects on the conclusions of a human health risk assessment or epidemiology study. In this analysis, a review of the key exposure reconstruction approaches described in over 400 papers in the peer-reviewed literature is presented. These approaches have been critically evaluated and classified according to quantitative, semiquantitative, and qualitative approaches. Our analysis indicates that much can still be done to improve the overall quality and consistency of exposure reconstructions and that a systematic framework would help to standardize the exposure reconstruction process in the future. The seven recommended steps in the exposure reconstruction process include identifying the goals of the reconstruction, organizing and ranking the available data, identifying key data gaps, selecting the best information sources and methodology for the reconstruction, incorporating probabilistic methods into the reconstruction, conducting an uncertainty analysis, and validating the results of the reconstruction. Influential emerging techniques, such as Bayesian data analysis, are highlighted. Important issues that will likely influence the conduct of exposure reconstruction into the future include improving statistical analysis methods, addressing the issue of chemical mixtures, evaluating aggregate exposures, and ensuring transparency with respect to variability and uncertainty in the reconstruction effort.


Asunto(s)
Teorema de Bayes , Exposición a Riesgos Ambientales/análisis , Contaminantes Ambientales/análisis , Contaminantes Ambientales/toxicidad , Salud Laboral , Estudios Epidemiológicos , Sustancias Peligrosas/toxicidad , Humanos , Medición de Riesgo , Incertidumbre
17.
Regul Toxicol Pharmacol ; 58(3): 524-38, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-20850490

RESUMEN

The concept of sustainability evolved throughout the 1970s and 1980s, but was formally described by the 27 principles of the Rio Declaration on Environment and Development in 1992. Despite the passage of nearly 20years, to date there are no uniform set of federal rules, regulations, or guidelines specifically governing the environmental aspects of sustainability practices or related requirements in the United States. In this benchmark analysis, we have collected information on the sustainability programs of the five largest US companies in each of the 26 industrial sectors [based on the Forbes Global 2000 through 2009 (n=130)]. For each company, we reviewed the most recent corporate sustainability, citizenship, or responsibility report, limiting our scope to environmental components, if available. Ten criteria were identified and analyzed, including leadership, reporting, external review, certification, and individual components of environmental sustainability programs. With respect to the prevalence of sustainability components between various business sectors, we found that the Drugs and Biotechnology (87%), Household and Personal Products (87%) and Oil and Gas Operations (87%) industries had the most comprehensive environmental sustainability programs. Using the nine components of environmental sustainability as a benchmark, we identified four key components as the characteristics of the most comprehensive environmental sustainability programs. These were (1) empowering leadership with a commitment to sustainability (80%), (2) standardized reporting (87%), (3) third-party evaluation of the sustainability programs (73%), and (4) obtaining ISO 14001 certification (73%). We found that many firms shaped their own definition of sustainability and developed their associated sustainability programs based on their sector, stakeholder interests, products or services, and business model. We noted an emerging area that we have called product sustainability - one in which toxicologists and environmental scientists can play a vital role helping to ensure that a manufactured item will indeed be considered acceptable for distribution now, as well as in the coming years. Numerous examples or case studies are presented.


Asunto(s)
Conservación de los Recursos Energéticos , Conservación de los Recursos Naturales , Política Ambiental , Corporaciones Profesionales/ética , Estudios Transversales , Ambiente , Política Ambiental/legislación & jurisprudencia , Europa (Continente) , Guías como Asunto , Humanos , Industrias , Corporaciones Profesionales/normas , Eliminación de Residuos/normas , Factores de Tiempo , Estados Unidos , Abastecimiento de Agua
18.
Risk Anal ; 29(12): 1699-725, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19948002

RESUMEN

Vinyl chloride (VC) was used as a propellant in a limited percentage of aerosol hairspray products in the United States from approximately 1967 to 1973. The question has arisen whether occupational exposures of hairdressers to VC-containing hairsprays in hair salons were sufficient to increase the risk for developing hepatic angiosarcoma (HAS). Transient two-zone and steady-state three-zone models were used to estimate the historical airborne concentration of VC for individual hairdressers using hairspray as well as estimated contributions from other hairdressers in the same salon. Concentrations of VC were modeled for small, medium, and large salons, as well as a representative home salon. Model inputs were determined using published literature, and variability in these inputs was also considered using Monte Carlo techniques. The 95th percentile for the daily time-weighted average exposure for small, medium, and large salons, assuming a market-share fraction of VC-containing hairspray use from the Monte Carlo analysis, was about 0.3 ppm, and for the home salon scenario was 0.1 ppm. The 95th percentile value for the cumulative lifetime exposure of the hairdressers was 2.8 ppm-years for the home salon scenario and 2.0 ppm-years for the small, medium, and large salon scenarios. If using the assumption that all hairsprays used in a salon contained VC, the 95th percentile of the theoretical lifetime cumulative dose was estimated to be 52-79 ppm-years. Estimated lifetime doses were all below the threshold dose for HAS of about 300 to 500 ppm-years reported in the published epidemiology literature.


Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Preparaciones para el Cabello/efectos adversos , Exposición Profesional , Cloruro de Vinilo/toxicidad , Contaminantes Ocupacionales del Aire/análisis , Contaminantes Ocupacionales del Aire/historia , Industria de la Belleza , Femenino , Preparaciones para el Cabello/análisis , Preparaciones para el Cabello/historia , Hemangiosarcoma/epidemiología , Hemangiosarcoma/etiología , Hemangiosarcoma/historia , Historia del Siglo XX , Humanos , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/etiología , Neoplasias Hepáticas/historia , Modelos Teóricos , Enfermedades Profesionales/epidemiología , Enfermedades Profesionales/etiología , Enfermedades Profesionales/historia , Exposición Profesional/historia , Medición de Riesgo , Estados Unidos/epidemiología , United States Occupational Safety and Health Administration , Cloruro de Vinilo/análisis , Cloruro de Vinilo/historia
19.
Arch Environ Occup Health ; 74(4): 197-205, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-29319452

RESUMEN

Few studies have evaluated airborne exposures to benzene, toluene, ethylbenzene, and xylenes (BTEX) during operation of two-stroke and four-stroke small engines, such as those in lawn maintenance equipment. Full-shift, 8-hour personal samples were collected during a simulation study to characterize yard maintenance activities including mowing, trimming, and fueling. Short-term, 15-minute personal samples were collected to separately evaluate mowing and trimming exposures. Mean 8-hour time weighted average (TWA) BTEX concentrations were 2.3, 5.8, 0.91, and 4.6 ppb, respectively (n = 2). Mean 15-minute TWA BTEX concentrations were 1.6, 1.8, 0.22, and 1.3 ppb, respectively, during mowing and 1.2, 3.6, 0.68, and 3.3 ppb, respectively, during trimming (n = 3 per task). Measured BTEX concentrations during fueling were 20-110, 61-310, 8-41, and 40-203 ppb, respectively (n = 2, duration 2-3 minutes). These exposure concentrations were well below applicable US occupational exposure limits.


Asunto(s)
Derivados del Benceno/análisis , Monitoreo del Ambiente , Exposición Profesional/análisis , Tolueno/análisis , Xilenos/análisis , Contaminantes Atmosféricos , Irán
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA