Detalles de la búsqueda
1.
Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study.
Molecules
; 27(12)2022 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35744791
2.
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.
Acta Crystallogr D Struct Biol
; 80(Pt 6): 386-396, 2024 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38805244
3.
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
Eur J Med Chem
; 268: 116193, 2024 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38364714
4.
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor.
FEBS Lett
; 597(16): 2119-2132, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37278160
5.
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication.
Antiviral Res
; 219: 105734, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37852322
6.
The Novel hDHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis.
Viruses
; 14(10)2022 10 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36298835
7.
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.
Eur J Med Chem
; 237: 114366, 2022 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35447434
8.
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia.
Cell Death Dis
; 13(6): 576, 2022 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35773274
9.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.
J Med Chem
; 65(19): 12701-12724, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36162075
10.
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication.
Antiviral Res
; 189: 105057, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33716051
11.
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats.
Brain Sci
; 12(1)2021 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35053779
12.
The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses.
Microorganisms
; 9(8)2021 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34442810
13.
The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia.
Cancers (Basel)
; 13(5)2021 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33670894
14.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety.
J Med Chem
; 64(9): 5404-5428, 2021 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33844533
15.
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
Eur J Med Chem
; 183: 111681, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31557612
16.
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
J Med Chem
; 62(9): 4467-4482, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30943028
17.
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.
Eur J Med Chem
; 163: 266-280, 2019 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30529545
18.
Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy.
Recent Pat Anticancer Drug Discov
; 13(1): 86-105, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29119937
19.
N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK.
Medchemcomm
; 9(6): 963-968, 2018 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30108985
20.
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
J Med Chem
; 61(14): 6034-6055, 2018 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29939742