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1.
Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kß/δ inhibitors for the treatment of PTEN-deficient tumours.
Bioorg Med Chem Lett
; 26(9): 2318-23, 2016 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26996374
2.
Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.
Bioorg Med Chem Lett
; 25(22): 5155-62, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26475521
3.
Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kß/δ inhibitors for the treatment of PTEN-deficient tumours.
Bioorg Med Chem Lett
; 24(16): 3928-35, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24992874
4.
Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kß and PI3Kδ for the treatment of PTEN-deficient cancers.
J Med Chem
; 58(2): 943-62, 2015 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-25514658
5.
Controlling mode selectivity in palladium-catalyzed bisdiene carbocyclizations: optimizing for cyclization-trapping over cycloisomerization.
Org Lett
; 5(20): 3595-8, 2003 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-14507181
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