Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis.

BACKGROUND: Atrial and ventricular cardiac arrhythmias are one of the most common early complications after cardiac surgery and these serve as a major cause of mortality and morbidity after cardiac revascularization. We want to evaluate the effect of magnesium sulfate administration on the incidence of cardiac arrhythmias after cardiac revascularization by doing this systematic review and meta-analysis. METHODS: The search performed in several databases (SID, Magiran, IranDoc, IranMedex, MedLib, PubMed, EmBase, Web of Science, Scopus, the Cochrane Library and Google Scholar) for published Randomized controlled trials before December 2017 that have reported the association between Magnesium consumption and the incidence of cardiac arrhythmias. This relationship measured using odds ratios (ORs) with a confidence interval of 95% (CIs). Funnel plots and Egger test used to examine publication bias. STATA (version 11.1) used for all analyses. RESULTS: Twenty-two studies selected as eligible for this research and included in the final analysis. The total rate of ventricular arrhythmia was lower in the group receiving magnesium sulfate than placebo (11.88% versus 24.24%). The same trend obtained for the total incidence of supraventricular arrhythmia (10.36% in the magnesium versus 23.91% in the placebo group). In general the present meta-analysis showed that magnesium could decrease ventricular and supraventricular arrhythmias compared with placebo (OR = 0.32, 95% CI 0.16-0.49; p < 0.001 and OR = 0.42, 95% CI 0.22-0.65; p < 0.001, respectively). Subgroup analysis showed that the effect of magnesium on the incidence of cardiac arrhythmias was not affected by clinical settings and dosage of magnesium. Meta-regression analysis also showed that there was no significant association between the reduction of ventricular arrhythmias and sample size. CONCLUSION: The results of this meta-analysis study suggest that magnesium sulfate can be used safely and effectively and is a cost-effective way in the prevention of many of ventricular and supraventricular arrhythmias.

Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis.

BACKGROUND: Premature birth is a primary cause of infant mortality and its etiology varies in different countries. Chlamydia trachomatis (CT) is a common infectious agent transmitted through sexual contact. The purpose of this study is to investigate the connection between CT infections and preterm birth by meta-analysis. METHODS: All articles published in literature databases including Google Scholar, PubMed, ISI (Web of Science), Biological Abs, IranMedex, SID, and Scopus were investigated. Twenty-four relevant articles, authored betweenm 1998-2014 were analyzed through a random effects model. Heterogeneity of the studies was evaluated by I2 index. The relationship between years of data collection, sample size, and CT infections with preterm delivery prevalence was examined by meta-regression. Data were analyzed with R and STATA [Ver. 12]. RESULTS: The overall prevalence of CT infections leading to preterm deliveries was estimated to be 0.13% (CI 95%: 0.11-0.16). The prevalence of CT infections leading to preterm deliveries were calculated based on the study method including PCR [0.06 (CI 95%: 0.04-0.09)], serology [0.23 (CI 95%: 0.10-0.35)] and culture [0.17 (CI 95%: 0.10-0.24)]. Analysis indicates that women with chlamydia infections were 2.28 more likely to deliver pre-term in comparison with those who were not infected. It can be concluded that chlamydia infections increase the risks of preterm delivery, OR = 2.28 (95% CI:1.64-3.16). CONCLUSIONS: In regard to the results in numerous studies performed on different continents, this meta- analysis showed a clear association between preterm delivery and prior CT colonization.

Prevalence of Infertility In Iran: A Systematic Review And Meta-Analysis.

PURPOSE: In the present study, a systematic review and meta-analysis was conducted to determine the prevalence of infertility in Iran. MATERIALS AND METHODS: A search of studies was performed in June 2019 on Scopus, PubMed, Web of Science (WOS), Scientific Information Database (SID), Magiran, Irandoc and Google scholar using keywords related to infertility. The search for articles was limited to those published over the past 20 years in Persian and English languages. In this research, only population-based studies were included. RESULTS: The results of the analysis showed that the overall prevalence of infertility was 7.88%, 95% CI: 5.61- 10.51. The prevalence of primary and secondary infertility after sensitivity analyses was 3.09%, 95% CI: 2.27- 4.02 and 2.18%, 95% CI: 1.56-2.89, respectively. The slope of meta-regression line showed that the prevalence of primary (P = .7) and secondary infertility (P = .4) is rising with a slow slope in Iran. CONCLUSION: It is emphasized that the results of this study are related to the areas where investigations have been conducted and that there is high heterogeneity in findings. Given that information is not available in all parts of Iran, a population-based study or the design and implementation of further research is suggested.

The association between iron deficiency anemia and febrile seizure.

OBJECTIVE: Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. PATIENTS AND METHODS: This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. RESULTS: A total of 34.6% in the FS group, 66.7% in the afebrile seizure group and 41.2% in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 [95% confidence interval (CI) = 0.34-1.68; p = 0.493] and that for FS compared to seizure was 0.265 (95% CI = 0.085-0.823; p = 0.022). CONCLUSIONS: This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended.

Relationship between Demographic Factors and Violence during Pregnancy in Iran: A Meta-Analysis Study.

Objective: Domestic violence is the most common form of violence against women and a major health problem worldwide. The aim of this study was to examine the relationship between demographic factors and domestic violence during pregnancy through meta-analysis. Method : This meta-analysis study was conducted in Iran. All the articles published during 2001 up to Jun 2018 were extracted independently by 2 trained investigators from domestic and foreign databases including, Science Medlib, SID, Web of Science, PubMed, Science Direct, Irandoc, Medline, Scopus, Magiran, and Google Scholar with keywords and their compounds. The results of studies pooled using the random effects model Cochran and I2 tests were used to check heterogeneity. Data were analyzed using Stata Ver. 11.2. Results: A total of 28 articles with the sample size of 15 020 people were included in the study. The findings of the meta-analysis showed that low level of maternal education (OR:1.68) (CI 95%:1.15, 2.46), low education level of the spouse (OR:1.73) (CI 95%:1.31, 2.29), unemployment of the husband (OR:1.61) (CI 95%: 1.05, 2.48), and smoking of the husband (OR:2.51) (CI 95%: 1.64, 3.84) were important factors in the increase in domestic violence during pregnancy. Having 3 children or fewer (OR: 0.30) (CI 95%: 0.16, 0.56) and enough and regular visits to physicians to receive adequate prenatal care (OR: 0.31) (CI 95%: 0.16, 0.57) were deterrent for violence during pregnancy. Conclusion: Based on our findings, level of education, unemployment, prenatal care, smoking, and number of children are associated with violence during pregnancy. Thus, paying attention to these factors and controlling them can reduce violence during pregnancy and its adverse consequences.

Prevalence, causes, and complications of cesarean delivery in Iran: A systematic review and meta-analysis.

BACKGROUND: Uncontrolled increase of C-section is one of the major problems in Iranian health system, such that C-section is the most common surgical procedure in the entire country's hospitals in Obstetrics and Gynecology sections. A variety of complications also come along with cesarean. OBJECTIVE: The aim of this study was to evaluate the prevalence, causes, and complications of cesarean in Iran. MATERIALS AND METHODS: forty-one articles were considered with respect to certain criteria and were included in a systematic review to perform a meta-analysis study. The systematic review's search was conducted on SID, Iranmedx, Magiran, Medlib, PubMed, and Science Direct databases published between1999-2016. The weight of each included study was calculated according to its sample size and the reported prevalence of binomial distribution. A random-effects model using R and STATA (Version 11.2) software was utilized for analyzing data. RESULTS: The total number of the sample was 197514 pregnant women with a mean age of 26.72 yr. The prevalence of cesarean in Iran was estimated at 48%. The main reasons for the prevalence of cesarean in this study were mothers' higher education, previous cesarean, and doctor recommendation. The most frequent complication in women undergoing cesarean was the muscular pain, and the most common fetal complications in newborns by caesarean delivery was transient tachypnea. CONCLUSION: The prevalence of C-section in Iran is much higher than what WHO recommends. It is essential, to decrease such a phenomenon, making the mothers aware of the risks of cesarean delivery, and establishing counselling sessions as well to eliminate the mothers' fear of vaginal delivery.

Synergistic Effect of Colistin and Rifampin Against Multidrug Resistant Acinetobacter baumannii: A Systematic Review and Meta-Analysis.

The existence of infections caused by multidrug resistant (MDR) Acinetobacter baumannii is a growing problem because of the difficulty to treat them. We examined the published literature and focused our analysis on the investigation of the synergism of colistin and rifampin against MDR A. baumannii isolates via systematic review and meta-analysis. A systematic literature search was performed using the following 4 databases (PubMed, Scopus, EMBASE and ISI Web of Sciences). The related articles were evaluated during the period from December 2014 to January 2015. Information based on resistance and sensitivity to antibiotics, the minimum inhibitory concentration and the effects of two antibiotics on each other including synergism, antagonism, relative synergism and additive antagonism were extracted. A meta-analysis of 17 studies including 448 samples was brought into process and 2% (95% CI 0-4%) and 72% (95% CI 56-89%) resistance to colistin and rifampin were observed, respectively. 42% of all isolates showed MIC = 4 µg/ml (95% CI 14-69%) to rifampin and 30% MIC= 2 µg/ml to colistin (95% CI 3.8-78%). MIC50 and MIC90 for both rifampin and colistin were 2 µg/ml and 4 µg/ml, respectively. 63% of the strains demonstrated synergy (95% CI 37-90%), 7% were highlighted as relative synergism (95% CI 0.0- 13%), 3% showed an additive effect (95% CI -0.0-7%) and 14% were indifferent (95% CI 6-23%). The antagonistic effect was not observed in this combination. Synergy rates of time-kill assay in rifampin and colistin combinations were generally higher than those of check bored microdilution and E-test method. The results demonstrated that the combination therapy could be more useful when compared to monotherapy and that this strategy might reduce the resistance rate to rifampin in MDR A. baumannii isolates.

Perceived Social Support, Self-Esteem, and Internet Addiction Among Students of Al-Zahra University, Tehran, Iran.

BACKGROUND: Internet addiction is a global phenomenon that causes serious problems in mental health and social communication. Students form a vulnerable group, since they have free, easy, and daily access to the internet. OBJECTIVES: The current study aimed to investigate perceived social support, self-esteem, and internet addiction among Al-Zahra University students. MATERIALS AND METHODS: In the current descriptive research, the statistical sample consisted of 101 female students residing at AL-Zahra University dormitory, Tehran, Iran. Participants were randomly selected and their identities were classified. Then, they completed the Multidimensional Scale of Perceived Social Support, Rosenberg's Self-esteem Scale, and Yang Internet Addiction Test. After completion of the questionnaires, the data were analyzed using the correlation test and stepwise regression. RESULTS: The Pearson correlation coefficient indicated significant relationships between self-esteem and internet addiction (P < 0.05, r = -0.345), perceived social support (r = 0.224, P < 0.05), and the subscale of family (r = 0.311, P < 0.05). The findings also demonstrated a significant relationship between internet addiction and perceived social support (r = -0.332, P < 0.05), the subscale of family (P < 0.05, r = -0.402), and the other subscales (P < 0.05, r = -0.287). Results of the stepwise regression showed that the scale of internet addiction and the family subscale were predicative variables for self-esteem (r = 0.137, P < 0.01, F2, 96 = 77.7). CONCLUSIONS: Findings of the current study showed that persons with low self-esteem were more vulnerable to internet addiction.

Evaluation of dairy allergy among ulcerative colitis patients.

The intestine is the largest mucosal organ of the body and also the first line immune homeostasis. Inflammatory bowel disease or IBD is divided into ulcerative colitis and Crohn's disease. One of the problems that can occur with UC is dietary allergy to some foods. This study aimed to evaluated the dairy allergy among patients with ulcerative colitis. This study is a Case - control study, that studied 72 patients with Ulcerative Colitis, after recording history of the disease, colonoscopy and confirmed by biopsy and 72 person without history of colitis. In this study, in order to investigate of food allergy, used of the EUROMMUM kit with an international code number DP3420-1601-11E. We used chi-square and Monte Carlo method for analysis of data. Among UC patients, 30.6% mild, 52.8% moderate and 16.6% of cases were in sever stage. 9.7% of them reported a history of abdominal surgery due to disease. According to the chi-square and Monte Carlo methods, dairy allergy (including: cow milk, cow milk UHT and casein) in UC group was significant (P=0.00). This study indicated that there is significant relationship between UC and cow milk, cow milk UHT and casein. UC patients who are allergic to dairy products and the use of dairy products can increase the severity of UC.