Detalles de la búsqueda
1.
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.
Nat Chem Biol
; 10(3): 181-7, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24390428
2.
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorg Med Chem Lett
; 22(6): 2230-4, 2012 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22361133
3.
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent ß isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorg Med Chem Lett
; 22(9): 3198-202, 2012 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22475557
4.
Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function.
Sci Rep
; 12(1): 14685, 2022 08 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-36038587
5.
Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines.
Bioorg Med Chem Lett
; 20(2): 684-8, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20006500
6.
Aminofurazans as potent inhibitors of AKT kinase.
Bioorg Med Chem Lett
; 19(5): 1508-11, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19179070
7.
Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.
Sci Rep
; 9(1): 13078, 2019 09 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31511536
8.
Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Arch Biochem Biophys
; 469(2): 220-31, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17999913
9.
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer Res
; 66(23): 11100-5, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17145850
10.
CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion.
Mol Cell Biol
; 22(1): 57-68, 2002 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-11739722
11.
Inhibition of a mitotic motor protein: where, how, and conformational consequences.
J Mol Biol
; 335(2): 547-54, 2004 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-14672662
12.
Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
ACS Med Chem Lett
; 6(5): 531-6, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26005528
13.
Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.
PLoS One
; 9(6): e100880, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24978597
14.
[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase ß Inhibitors.
ACS Med Chem Lett
; 4(2): 230-4, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900655
15.
Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors.
ACS Med Chem Lett
; 3(7): 524-9, 2012 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900504
16.
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
J Med Chem
; 51(18): 5663-79, 2008 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18800763
17.
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
J Med Chem
; 51(14): 4239-52, 2008 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-18578472
18.
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.
Arch Biochem Biophys
; 464(1): 130-7, 2007 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17490600
19.
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 16(7): 1775-9, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16439123
20.
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 16(12): 3175-9, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16603356