1.
Bioorg Med Chem Lett
; 23(23): 6239-42, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24157365
RESUMEN
Hit-to-lead medicinal chemistry efforts are described starting from a screening hit 1, leading to a new class of aryl sulfonamide-based MR antagonist, exemplified by 17, that possesses favourable MR binding affinity, selectivity profile against closely related NHRs, physicochemical properties and metabolic stability.