Asunto(s)
Células Dendríticas/patología , Linfoma no Hodgkin/patología , Neoplasias Cutáneas/patología , Anciano , Antígenos CD/análisis , Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Asparaginasa/administración & dosificación , Médula Ósea/patología , Trasplante de Médula Ósea , Terapia Combinada , Ciclofosfamida/administración & dosificación , Citarabina/administración & dosificación , Daunorrubicina/administración & dosificación , Células Dendríticas/química , Progresión de la Enfermedad , Doxorrubicina/administración & dosificación , Humanos , Inmunofenotipificación , Leucemia Mielomonocítica Aguda/patología , Ganglios Linfáticos/patología , Linfoma no Hodgkin/diagnóstico , Linfoma no Hodgkin/tratamiento farmacológico , Linfoma no Hodgkin/cirugía , Masculino , Mercaptopurina/administración & dosificación , Metotrexato/administración & dosificación , Persona de Mediana Edad , Prednisona/administración & dosificación , Pronóstico , Inducción de Remisión , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/cirugía , Trasplante Homólogo , Vincristina/administración & dosificaciónRESUMEN
A 60-year-old woman presented with a pigmented lesion on the upper left gingival mucosa of 2 years duration. The lesion was in an area where a dental metallic prosthesis had been inserted into a nearby tooth several years earlier. A biopsy of the affected mucosa showed aggregates of pigmented granules varying in size in the dermis, extracellular matrix and within macrophages; these did not stain with melanin stains. The diagnosis was consistent with an amalgam tattoo.
Asunto(s)
Amalgama Dental/efectos adversos , Prótesis Dental/efectos adversos , Mucosa Bucal/patología , Trastornos de la Pigmentación/diagnóstico , Trastornos de la Pigmentación/etiología , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Enfermedad Iatrogénica , Persona de Mediana EdadRESUMEN
272 children up to the age of 14 years were patch tested during a 10-year period (1982-1991). 101 children (37.1%) gave positive reactions to 1 or more allergens. Of these, 54.4% (57/101), were considered relevant. The main allergens were, in order of frequency: nickel, rubber compounds, mercuric chloride, cobalt salts, thimerosal, benzoyl peroxide and fragrance mix.
Asunto(s)
Alérgenos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Adolescente , Niño , Preescolar , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/epidemiología , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Pruebas del ParcheRESUMEN
The accessibility of the skin to light treatment, as well as the developments made by dermatologists in photodynamic therapy (PDT), creates an exciting apportunity to include it as a part of our standard therapeutic armamentarium. We report a 63-year-old man with an in situ squamous cell carcinoma located on a chronic radiodermitis area in a finger, treated successfully with PDT. PDT appears to be a viable alternative to conventional therapy for in situ squamous cell carcinoma as well as for other superficial tumours of the skin.
Asunto(s)
Carcinoma in Situ/tratamiento farmacológico , Carcinoma de Células Escamosas/tratamiento farmacológico , Fotoquimioterapia , Radiodermatitis/tratamiento farmacológico , Neoplasias Cutáneas/tratamiento farmacológico , Ácido Aminolevulínico/administración & dosificación , Dedos , Humanos , Masculino , Persona de Mediana Edad , Fármacos Fotosensibilizantes/administración & dosificaciónRESUMEN
The patient, aged 50 years, with no relevant clinical history, complained of a symptomless, soft tumor of the right buttock that had been present for many years. On examination, it was found to be pediculate, oval, somewhat erythematous, firm on palpation, and with a central keratin plug. The greatest diameter of the lesion was 1.2 cm (Fig. 1). On surgical removal of the lesion, it was seen to be composed of a symmetric intradermal proliferation of cystic formations, uniformly distributed throughout and made up of flat, pluristratified epithelium with laminated keratin. There was little difference in the thickness of the walls of the cysts (Fig. 2). Some cysts were attached to a short tadpole-shaped, epithelial cord and surrounded by a scanty fibroblastic stroma. No hairmatrix-like differentiation nor basaloid structures were seen, nor were atypical cells present. There was hardly any inflammatory infiltration.
Asunto(s)
Neoplasias Basocelulares/patología , Neoplasias Cutáneas/patología , Nalgas , Quistes/patología , Epitelio/patología , Fibroblastos/patología , Humanos , Queratinas , Persona de Mediana EdadRESUMEN
We describe the case of a woman from a small town in the south of Spain, with consanguineous parents, who presented with the complete syndrome. The main clinicopathological characteristics are discussed.
Asunto(s)
Eritrodermia Ictiosiforme Congénita/patología , Errores Innatos del Metabolismo Lipídico/patología , Consanguinidad , Femenino , Humanos , Queratinocitos/patología , Persona de Mediana Edad , Síndrome , Vacuolas/patologíaRESUMEN
Heterotopic islands of salivary-gland tissue are rare and have been described in a number of sites in the head and neck. We describe a patient with salivary-gland fistulas in the lower third of the neck, without evidence of any other congenital abnormalities. The appearance of sinuses in association with heterotopic salivary-gland tissue suggests that its embryologic origin may be from the branchial clefts. Surgical treatment is recommended.
Asunto(s)
Coristoma/diagnóstico , Fístula Cutánea/diagnóstico , Glándulas Salivales , Niño , Coristoma/patología , Coristoma/cirugía , Fístula Cutánea/patología , Fístula Cutánea/cirugía , Diagnóstico Diferencial , Femenino , Humanos , CuelloRESUMEN
The appearance of pigmented lesions in melanoma surgical scars is a frequent finding that in some instances may cause confusion with a melanoma persistence. Nevertheless, only a few papers have dealt with this subject in the dermatologic literature. The melanoma surgical scars of 60 consecutive patients were reviewed with special attention to the presence of pigmentation and its clinical characteristics. Simultaneously, the scars of 60 consecutive patients who had been subjected to excision of a non-melanoma skin tumor were also studied. Biopsies were performed in representative clinical cases of pigmented lesions arising on the scars of both groups, as well as in non-pigmented scars, and processed for hematoxylin-eosin and immunohistochemistry. Pigmented lesions were present in a similar percentage in both groups (30% in melanoma scars (18/60) and 25% in non-melanoma scars (15/60)). Clinically, three types of clinical pigmentation were observed: lentigine-like lesions; pigmented streaks in scars after direct closure; and diffuse pigmentation in grafts. Histologically, two patterns emerged: one with lentiginous epidermal hyperplasia, hyperpigmentation, and a normal or moderately increased number of melanocytes; and a second one characterized by melanocytic hyperplasia of a variable degree. The scar process itself, irrespective of the tumor excised, seems to be responsible for the pigmentation. We suggest the existence of an induction process of scar tissue acting on melanocytes of the overlying epidermis.
Asunto(s)
Cicatriz/patología , Melanoma/patología , Trastornos de la Pigmentación/patología , Neoplasias Cutáneas/patología , Pigmentación de la Piel , Adulto , Anciano , Anciano de 80 o más Años , Antígenos de Neoplasias , Femenino , Humanos , Hiperplasia , Técnicas para Inmunoenzimas , Lentigo/patología , Masculino , Melanocitos/química , Melanocitos/patología , Melanoma/complicaciones , Melanoma/cirugía , Antígenos Específicos del Melanoma , Persona de Mediana Edad , Proteínas de Neoplasias/análisis , Trastornos de la Pigmentación/etiología , Proteínas S100/análisis , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/cirugíaRESUMEN
Videomicroscopy has been found to be useful in determining the depth of ectasia of vascular malformations. Different patterns that hypothetically could predict the response of a vascular malformation to pulsed dye laser have been described. Our purpose was to determine if the dermoscopy pattern was able to predict the response to pulsed dye laser therapy and if it was independent of other known clinical variables. Thirty-three consecutive children presenting for evaluation or treatment of vascular malformations underwent videomicroscopy previous to pulsed dye laser therapy. Sixty-nine representative areas were evaluated before and after laser therapy. Other clinical factors, including location of the malformation, the patient's age and sex, and previous therapy, were also included in the analysis. We found that the dermoscopy pattern was differently distributed depending on the anatomic area. A superficial pattern was not present in the centrofacial area. An undefined pattern was most often present when a previously treated area was imaged. A superficial pattern independently predicted a good response to laser. The location of the lesion was another independent factor influencing the outcome. A new pattern consisting of a pale circular area surrounding a central brownish dot is described as negatively influencing the response to laser therapy. We concluded that videomicroscopy is a good tool for assessing which vascular malformations can be adequately treated with laser therapy, although other anatomic factors can influence the response. Videomicroscopy is particularly helpful in deciding when to end the treatment because it objectively shows when no further response can be expected, and is helpful for demonstrating this to patients and their parents.
Asunto(s)
Rayos Láser , Microscopía por Video/métodos , Mancha Vino de Oporto/diagnóstico , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Mancha Vino de Oporto/epidemiología , Mancha Vino de Oporto/etiología , Mancha Vino de Oporto/fisiopatología , Valor Predictivo de las Pruebas , España/epidemiologíaRESUMEN
Benign lymphangioendothelioma (BL) is a rare vascular neoplasm that can histopathologically mimic a low-grade angiosarcoma or the patch stage of Kaposi sarcoma. We report on the case of a 49-year-old man with a benign lymphangioendothelioma on the right thigh that evolved on a vascular birthmark after a trauma. Because of constant pain and the slow but progressive growth of the lesion, we decided to excise the tumor. Three stages of surgery were needed to obtain negative margins. We review the reports of BL to date, with special attention to those that developed after trauma and those that had a preexistent vascular lesion, and expound on the histopathologic differential diagnosis with low-grade angiosarcoma.
Asunto(s)
Hemangiosarcoma/diagnóstico , Linfangioma/diagnóstico , Neoplasias Vasculares/diagnóstico , Biomarcadores de Tumor/análisis , Diagnóstico Diferencial , Humanos , Inmunohistoquímica , Linfangioma/química , Linfangioma/etiología , Linfangioma/cirugía , Masculino , Persona de Mediana Edad , Muslo/patología , Neoplasias Vasculares/química , Neoplasias Vasculares/etiología , Neoplasias Vasculares/cirugía , Heridas y Lesiones/complicaciones , Heridas y Lesiones/patologíaRESUMEN
Xeroderma pigmentosum (XP) is an autosomal recessive disease in which patients have a 1000-fold increased risk of developing cutaneous neoplasms. Management of patients with XP is a difficult therapeutic challenge as they usually present with many cutaneous malignancies and continue to form skin tumours at a high rate. We describe a 19-year-old woman with XP who had been previously treated with many different therapeutic approaches. She had an excellent clinical response of her multiple small pigmented basal cell carcinomas and pigmentary changes using imiquimod 5% cream with only minor side-effects.