The interplay between androgens and the immune response in polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, standardized criteria have been developed for its diagnosis. The general consensus is that hyperandrogenism is the primary feature of PCOS and is associated with an array of physiological dysfunctions; excess androgens, for example, have been correlated with cytokine hypersecretion, adipocyte proliferation, and signaling pathway dysregulation. Another key feature of PCOS is insulin resistance, resulting in aberrant glucose and fatty acid metabolism. Additionally, the immune system plays a key role in PCOS. Hyperandrogenism stimulates some immune cells while it inhibits others, thereby disrupting the normal balance of immune cells and creating a state of chronic inflammation. This low-grade inflammation could contribute to infertility since it induces ovarian dysfunction. This dysregulated immune response in PCOS exhibits autoimmunity characteristics that require further investigation. This review paper examines the relationship between androgens and the immune response and how their malfunction contributes to PCOS.

Enhanced uranium extraction from seawater: from the viewpoint of kinetics and thermodynamics.

Uranium extraction from seawater (UES) is recognized as one of the seven pivotal chemical separations with the potential to revolutionize global paradigms. The forthcoming decade is anticipated to witness a surge in UES, driven by escalating energy demands. The oceanic reservoirs, possessing uranium quantities approximately 1000-fold higher than terrestrial mines, present a more sustainable and environmentally benign alternative. Empirical evidence from historical research indicates that adsorption emerges as the most efficacious process for uranium recovery from seawater, considering operational feasibility, cost-effectiveness, and selectivity. Over the years, scientific exploration has led to the development of a plethora of adsorbents with superior adsorption capacity. It would be efficient to design materials with a deep understanding of the adsorption from the perspective of kinetics and thermodynamics. Here, we summarize recent advancements in UES technology and the contemporary challenges encountered in this domain. Furthermore, we present our perspectives on the future trajectory of UES and finally offer our insights into this subject.