Nonsteroidal anti-inflammatory drug monitoring in serum: a Tb-MOF-based luminescent mixed matrix membrane detector with high sensitivity and reliability.

The identification of drugs or biomolecules for public health monitoring requires facile analytical technologies with excellent sensitivity, portability and reliability. In the past decades, different sensing materials have inspired the development of various bioanalytical strategies. However, sensing platforms based on powder materials are not suitable for medical diagnosis, which limits further exploration and application of biosensors. Herein, a point-of-care testing (POCT) membrane was designed from an energy competition mechanism and achieved the detection of the nonsteroidal antiphlogistic diclofenac, and exhibited remarkable testing efficacy at the ppb level. The mixed matrix membrane (MMM) sensor consists of electrospun polyacrylonitrile nanofibers and luminescent Tb-MOFs and possess the advantages of high stability, outstanding anti-interference ability, efficient detection (LOD = 98.5 ppb) and easy visual recognition. Furthermore, this MMM sensor exhibits excellent recyclability in serum, which is beneficial for developing a portable and convenient device to distinguish diclofenac in practical sensing applications. Meanwhile, the feasibility and mechanism of this recyclable sensor were verified by theory and experiments, indicating that it is a promising device for diclofenac detection in biological environments to evaluate the toxic effect caused by the accumulation of nonsteroidal drugs.

The salen based chemosensors for highly selective recognition of Zn2+ ion.

Two novel salen based chemosensors have been successfully synthesized. UV-vis absorption, fluorescence emission spectroscopy and cyclic voltammetry (CV) were exploited to investigate their recognition toward various metal ions, including Na+, K+, Mg2+, Al3+, Zn2+, Ag+, Pb2+, Co2+, Li+, Ba2+, Ca2+, Cd2+, La3+, Cu2+ and Mn2+ ions. The results indicated that the sensor L1 and L2 exhibited highly selective and sensitive recognition for Zn2+ ions. The binding stoichiometry ratio of L1-Zn2+/L2-Zn2+ were recognized as 4:1 by the method of Job's plot. Meanwhile, this investigation is confirmed by 1H NMR. These results indicated that L1 and L2 can be applied as chemosensor for the detection of Zn2+ ion.