Asunto(s)
Neoplasias de los Bronquios/complicaciones , Tumor Carcinoide/complicaciones , Síndrome de Cushing/etiología , Tiña/etiología , Hormona Adrenocorticotrópica/metabolismo , Adulto , Neoplasias de los Bronquios/metabolismo , Tumor Carcinoide/metabolismo , Síndrome de Cushing/complicaciones , Síndrome de Cushing/diagnóstico , Femenino , HumanosRESUMEN
Invasive aspergillosis (IA) is a life-threatening infection. IA is usually seen in severely immunocompromised patients. However, IA as a presenting feature of non-Hodgkin's lymphoma is rare. The patient we describe had no signs or symptoms of lymphoma prior to hospital admission. A. fumigatus was isolated from respiratory tract specimens on the day of admission and fungal elements were detected on autopsy. Isolation of Aspergillus in patients with severe sepsis should trigger a search haematological malignancy.
RESUMEN
Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.