1.
Bioorg Med Chem Lett
; 19(11): 3136-40, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19394223
RESUMEN
Exploration of the SAR around a series of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines led to the discovery of novel pyrrolopyridine inhibitors of the IGF-1R tyrosine kinase. Several compounds demonstrated nanomolar potency in enzyme and cellular mechanistic assays.