The effect of background liked music on acute pain perception and its neural correlates.

Music shows tremendous promise in pain relief, especially when considering its non-pharmacological nature. However, our understanding of the precise mechanisms behind music-induced analgesia (MIA) remains poor. The positive emotional state induced by music is one of the key components explaining MIA. To test this possibility and reveal its neural correlates, the present study applied nociceptive laser stimuli to 28 healthy participants when their liked or disliked songs were played as background music, or when they were resting in silence. Differences among conditions were quantified by self-reports of pain intensity and unpleasantness, as well as brain activations in response to acute laser stimuli. As expected, liked music significantly lowered pain ratings to acute painful stimuli compared to disliked music and no music. Consistent with this observation, brain activations in response to acute painful stimuli were deceased within brain areas encoding sensory components of pain, such as the right precentral and postcentral gyri (PreCG/PoCG), brain areas related to affective components of pain, such as the anterior cingulate cortex and bilateral putamen, and brain areas associated with motor control and avoidance reactions to pain, such as the left cerebellum, when liked music was played in the background in comparison to disliked music. Importantly, the relationship between music listening and differences in pain ratings of two music conditions was mediated by the magnitude of right PreCG/PoCG and left cerebellum activations. These findings deepened our understanding of the analgesic benefits of background liked music, a property relevant to clinical applications.

Collective self-referential processing evoked by different national symbols: An event-related potential study.

The collective self is an important representation of self-concept, especially for people in collectivism culture. However, it is not clear whether there are differences in the self-reference effects caused by different collective self-relevant stimuli. The present study aimed to explore the temporal characteristics of collective self-referential processing evoked by polarized and unpolarized national symbols. Event-related potentials (ERPs) were recorded for pictures of national symbols and self-irrelevant pictures when 25 female participants performed a three-stimulus oddball task. The results indicate that compared to self-irrelevant pictures, both national symbols elicited collective self-reference effects on N2, P3, and LPP amplitudes. Polarized and unpolarized national symbols showed differences in N2 and P3 amplitudes. Moreover, national identity level was correlated with N2 and P3 amplitudes elicited by unpolarized symbols, and early LPP amplitudes elicited by both symbols. These results suggest greater recruitment of resources to process national symbols, and inconsistent time courses of processing different national symbols. Polarized symbols may consume more resources because of the internal complexity of their self-representations. The present study expands the research on collective self and its self-referential effect on women, and provides some enlightenment for understanding the internal factors that influence the strength of the self-reference effect.

"Watching Eyes" Triggers Third-Party Punishment: The Role of Emotion Within the Eyes.

Third-party punishment refers to a behavioral phenomenon whereby people punish wrongdoers even if their sanction incurs personal costs but yields no direct benefits. Given the eye cues demonstrated ability to convey signals of being observed, its effect on third-party punishment, driven by virtue of its effects on others' perceptions, was investigated. In addition, emotional message featured in the eye region is crucial in social interaction, whether the emotion within the eyes serves this effect with varying degrees of influence has rarely considered. The present study aimed at exploring (a) the watching eyes effect on the third-party punishment and (b) whether this effect varies from negative eyes to positive eyes. By two experiments using a modified Third-Party Dictator Game, we displayed either eye images or control images above the question on whether to punish the dictators or not. There was no emotional diversity of eye cues in Experiment 1, and most participants tended to punish for unfair offer. However, the appearance of eye images increased the punishment relative to control images. In Experiment 2, the eye cues were subdivided into positive and negative. The effect of watching eyes on the third-party punishment was significantly stronger when the eyes were negative than positive. Results revealed that eye cues play a role in promoting the third-party punishment and offer a potential insight into the mixed findings, such that the emotion within the eyes, especially the negative expression in the eyes, may influence the watching eyes effect.

Whole-brain resting-state functional connectivity identified major depressive disorder: A multivariate pattern analysis in two independent samples.

BACKGROUND: there has been a recent increase in the use of connectome-based multivariate pattern analysis (MVPA) of resting-state functional magnetic resonance imaging (fMRI) data aimed at distinguishing patients with major depressive disorder (MDD) from healthy controls (HCs). However, the validity of this method needs to be confirmed in independent samples. METHOD: we used resting-state fMRI to explore whole-brain functional connectivity (FC) patterns characteristic of MDD and to confirm the effectiveness of MVPA in distinguishing MDD versus HC groups in two independent samples. The first sample set included 29 MDD patients and 33 HCs and second sample set included 46 MDD patients and 57 HCs. RESULTS: for the first sample, we obtained a correct classification rate of 91.9% with a sensitivity of 89.6% and specificity of 93.9%. For the second sample, we observed a correct classification rate of 86.4% with a sensitivity of 84.8% and specificity of 87.7%. With both samples, we found that the majority of consensus FCs used for MDD identification were located in the salience network, default mode network, the cerebellum, visual cortical areas, and the affective network. LIMITATION: we did not analyze potential structural differences between the groups. CONCLUSION: results suggest that whole-brain FC patterns can be used to differentiate depressed patients from HCs and provide evidence for the potential use of connectome-based MVPA as a complementary tool in the clinical diagnosis of MDD.

Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.

Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between MDD and SZ, which supported a transdiagnostic approach. Therefore, we used activation likelihood estimation (ALE) meta-analysis of functional magnetic resonance imaging studies in MDD and SZ to examine the neural bases of three subdomains of anhedonia: consummatory anhedonia, anticipatory anhedonia and emotional processing. ALE analysis focused specifically on MDD or SZ was used later to dissociate specific anhedonia-related neurobiological impairments from potential disease general impairments. ALE results revealed that consummatory anhedonia was associated with decreased activation in ventral basal ganglia areas, while anticipatory anhedonia was associated with more substrates in frontal-striatal networks except the ventral striatum, which included the dorsal anterior cingulate, middle frontal gyrus and medial frontal gyrus. MDD and SZ patients showed similar neurobiological impairments in anticipatory and consummatory anhedonia, but differences in the emotional experience task, which may also involve affective/mood general processing. These results support that anhedonia is characterized by alterations in reward processing and relies on frontal-striatal brain circuitry. The transdiagnostic approach is a promising way to reveal the overall neurobiological framework that contributes to anhedonia and could help to improve targeted treatment strategies.

Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients.

Previous studies have focused on resting-state default mode network (DMN) alterations in the development and maintenance of depression; however, only a few studies have addressed DMN changes during task-related processing and their results are inconsistent. Therefore, we explored DMN patterns in young adult patients with first-episode, treatment-naïve major depressive disorder (MDD) performing an implicit emotional processing task. Patients with MDD (N = 29) and healthy controls (N = 33) were subjected to functional magnetic resonance imaging (fMRI) at rest and while performing a gender judgment task. Group independent component analysis (ICA) was used to identify DMN component under task state for both groups. The DMN of participants with MDD had decreased functional connectivity in bilateral prefrontal areas compared to controls. Right prefrontal gyrus connectivity for MDD patients correlated negatively with scores on maladaptive scales of the Cognitive Emotion Regulation Questionnaire (CERQ). Our findings suggest that depressed people have altered DMN patterns during implicit emotional processing, which might be related to impaired internal monitoring and emotional regulation ability.

Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder.

Alack of inhibition control has been found in subjects with conduct disorder (CD), but the underlying neuropathophysiology remains poorly understood. The current study investigated the different mechanism of inhibition control in adolescent-onset CD males (n = 29) and well-matched healthy controls (HCs) (n = 40) when performing a GoStop task by functional magnetic resonance images. Effective connectivity (EC) within the inhibition control network was analyzed using a stochastic dynamic causality model. We found that EC within the inhibition control network was significantly different in the CD group when compared to the HCs. Exploratory relationship analysis revealed significant negative associations between EC between the IFG and striatum and behavioral scale scores in the CD group. These results suggest for the first time that the failure of inhibition control in subjects with CD might be associated with aberrant connectivity of the frontal-basal ganglia pathways, especially between the IFG and striatum.

Sex differences of uncinate fasciculus structural connectivity in individuals with conduct disorder.

Conduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls.

Increased structural connectivity in corpus callosum in adolescent males with conduct disorder.

OBJECTIVE: Adolescents with conduct disorder (CD) are at high risk for developing adult antisocial personality disorder. However, the underlying neuropathophysiology of CD remains poorly understood. We hypothesized that the microstructure of white matter (WM) of males with CD may differ from that of healthy control subjects (HCs). METHOD: Tract-based spatial statistics (TBSS) and quantitative tractography were used to assess WM microstructural differences between 36 teenaged boys with CD and 33 demographically matched HCs. RESULTS: The CD group behavioral scale scores were significantly higher than those of the HCs on the Barratt Impulsivity Scale, the Strength and Difficulties Questionnaire, and the Antisocial Process Screening Device total scales. TBSS revealed that, relative to HCs, the CD group had higher fractional anisotropy (FA) in the corpus callosum (CC) region, bilaterally, including the genu and body of the CC, as well as in some projection fibers in the region of the left anterior coronal radiate and right superior coronal radiate. Tractography confirmed higher FA of fibers passing through the regions with significant differences in the TBSS results. Exploratory analysis revealed that impulsivity associated positively with the FA of these fibers in the CD group. CONCLUSIONS: Maturation of WM microstructure in CD subjects differed from that in HCs, mainly in the CC. The abnormal maturation of WM structures may play an important role in the impulsivity and aggression of teenagers with CD.

Comparison of activation patterns between masking and inattention tasks: a coordinate-based meta-analysis of implicit emotional face processing.

Neuroimaging studies of implicit emotional processing are important for understanding the neural mechanisms and its social and evolutionary significance. Two major experimental tasks are used to explore the mechanisms of implicit emotional processing: masking tasks and inattention tasks, both using emotional faces as stimuli. However, it is unclear whether they have identical or distinct neural substrates since few studies have compared the two tasks. The purpose of the present study was to explore the mechanisms of implicit processing of emotional faces, and compare the activation patterns between different tasks. Through a literature search, 41 studies exploring implicit processing of emotional faces were collected. A total of 830 healthy subjects and 513 foci were obtained. Separate activation likelihood estimation (ALE) meta-analyses were conducted for the entire group of studies and for different tasks for comparison purposes. The results showed that there were differences, as well as overlap, in activation patterns between masking and inattention tasks. Bilateral amygdala, middle occipital gyrus and fusiform gyrus were activated across both tasks. While masking tasks were more associated with inferior temporal gyrus, parahippocampal gyrus and amygdala, inattention tasks were more associated with right fusiform gyrus. The differences in activation patterns between masking and inattention tasks may be indicative of separate mechanisms underlying early and late stages of implicit emotional face processing.

Amplitude and latency of feedback-related negativity: aging and sex differences.

Feedback-related negativity (FRN) is an electrophysiological index associated with impulsivity. However, the age and sex effects on FRN are not well understood. Using the single-outcome gambling task, this study investigated age-related and sex-related differences between the FRN in middle and late adolescents and adults. Forty healthy adolescents (15-17 years old) and 28 healthy adults (20-25 years old) were recruited in the event-related potentials study. The electrophysiological response to gains and losses of low and high magnitude were recorded during the single-outcome gambling task. The FRN significantly delayed in middle and late adolescents compared with adults (232.875 vs. 211.714 ms). Adults are more sensitive to the magnitude of feedback (larger amounts: 50 cents vs. small amounts: 10 cents) than valence (gain: +50/10 vs. loss: -50/10). However, middle and late adolescents are neither sensitive to magnitude nor to valence. Men showed significantly more negative FRN amplitude than women both in adolescents and adults. In addition, the hostility subscore of the Buss-Perry Aggression Questionnaire was negatively correlated with FRN amplitude. The results of this study suggested that the age-related differences did exist between the FRN in adolescents and those in adults. Men require more neural activity than women to achieve similar feedback both in adolescents and adults.