RESUMEN
The aim of the present study was to analyze the effects of melatonin treatment on diabetic rat testes. Fifty albino rats were divided into the following groups: CG: control group; GD: placebo-induced and placebo-treated mice; GDI: insulin-induced and post-confirmation diabetes-induced rats; GDM: diabetes-induced and melatonin-treated post-confirmation mice and GDMS: diabetes-induced and melatonin-treated mice simultaneously. Melatonin was administered at a dose of 10â¯mg/kg in drinking water every day for 20 days at night. Diabetes was induced by streptozotocin (60â¯mg/kg) and confirmed after the fifth day of induction. Insulin was administered at 5 IU (international units)/day at different times of the day for 20 days. The testes were submitted to histopathological, morphometric, immunohistochemical and oxidative stress analysis. Melatonin moderately decreased glycemic levels, protected weight loss and morphometric changes in the testicles, increased antioxidant enzyme levels and stabilized plasma testosterone and androgen receptor levels and decreased inflammatory markers in the testicles. Showing its potential to mitigate diabetes effects.
Asunto(s)
Antioxidantes/farmacología , Diabetes Mellitus Experimental/tratamiento farmacológico , Melatonina/farmacología , Testículo/efectos de los fármacos , Animales , Peso Corporal/efectos de los fármacos , Diabetes Mellitus Experimental/sangre , Peroxidación de Lípido/efectos de los fármacos , Masculino , Estrés Oxidativo/efectos de los fármacos , Ratas Wistar , Estreptozocina/farmacologíaRESUMEN
O artigo visa debater uma proposta de matriciamento sobre a temática "Violência contra Crianças" voltada para profissionais da Estratégia Saúde da Família (ESF), como forma de prevenção e construção de estratégias de enfrentamento. Método: trata-se de um relato de experiência. Como eixo norteador da intervenção, foram realizadas oficinas temáticas junto a profissionais de três equipes de ESF, no município de Jaboatão dos Guararapes, Pernambuco. Resultados: são destacadas duas dimensões para apreciação da experiência: a primeira considera os efeitos da intervenção proposta, destacando suas ressonâncias e possibilidades de transformação nas equipes; a segunda reflete as dificuldades enfrentadas, indicando as limitações e desafios. Conclusão: a maioria dos profissionais se sente despreparada para lidar com a violência presente no território. É necessário que iniciativas educacionais, como a proposta, sejam desenvolvidas sobre o tema, visando a qualificação das equipes. Apontamos o uso das oficinas como ferramenta estratégica para o Apoio Matricial.
The article aims to debate a proposal for enrollment on the theme "Violence against Children" aimed at professionals of the Family Health Strategy (ESF), as a way of preventing and building coping strategies. Method: this is an experience report. As the northern axis of the intervention, thematic workshops were held with professionals from three ESF teams, in the municipality of Jaboatão dos Guararapes, Pernambuco. Results: two dimensions are highlighted for the appreciation of the experience: a first consideration of the effects of the proposed intervention, highlighting its resonances and possibilities of transformation in the teams; the second reflection as difficulties faced, specify as limitations and challenges. Conclusion: most professionals feel unprepared to deal with the violence present in the territory. It is necessary that educational initiatives, as a proposal, be developed on the theme, allow the qualification of the teams. We point out the use of workshops as a strategic tool for Matrix Support.