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1.
Vnitr Lek ; 59(11): 1003-7, 2013 Nov.
Artículo en Checo | MEDLINE | ID: mdl-24279445

RESUMEN

BACKGROUND: The type 2 Diabetes Mellitus treatment is currently effective but still not ideal. A therapy based on the incretins, which represents a significant qualitative progress, is close to an ideal. The first completed mortality study with dipeptidyl peptidase (DPP 4) inhibitors is the study called SAVOR as presented in Amsterdam during the European Cardiology Congress in 2013. METHODOLOGY: SAVOR (Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus) randomised 16,492 patients with Type 2 Diabetes Mellitus and a high-risk of cardiovascular events treated with current per oral antidiabetics and patients treated with saxagliptin or placebo. Eight thousand eight hundred and twenty patients were randomised to be treated with saxagliptin and 8,212 were randomised to be treated with placebo. The average monitored period was 2.1 years. RESULTS: The primary goal (cardiovascular death, nonfatal myocardial infarction and nonfatal CMP) occurred in 7.3% (613) patients treated with saxagliptin and in 7.2% (609) patients treated with placebo (HR 1.00, p < 0.001 for non inferiority). The main secondary goal (cardiovascular death, myocardial infarction, vascular stroke, hospitalisation for a heart failure or angina pectoris and myocardial revascularisation) occurred in 12.8% (1,059) patients treated with saxagliptin and in 12.4% (1,034) patients treated with placebo. The number of hospitalisations for heart failure was 289 (3.5%) in the group treated with saxagliptin and 228 (2.8%) in the group treated with placebo (p = 0.007). CONCLUSION: DPP 4 inhibitor saxagliptin did not increase the occurrence of ischemic cardiovascular events but it inclined to an increased hospitalisation for heart failure in patients with the already present heart failure. It did not increase the occurrence of pancreatitis. Simultaneously it significantly improved the Diabetes Mellitus control, which could signal a future improvement in cardiovascular goals.


Asunto(s)
Adamantano/análogos & derivados , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Dipéptidos/uso terapéutico , Cardiopatías/prevención & control , Insuficiencia Cardíaca/prevención & control , Infarto del Miocardio/prevención & control , Adamantano/efectos adversos , Adamantano/uso terapéutico , Anciano , Estudios Transversales , República Checa , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/mortalidad , Dipéptidos/efectos adversos , Femenino , Cardiopatías/etiología , Cardiopatías/mortalidad , Insuficiencia Cardíaca/etiología , Insuficiencia Cardíaca/mortalidad , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/etiología , Infarto del Miocardio/mortalidad , Análisis de Supervivencia
2.
Vnitr Lek ; 58(2): 89-93, 2012 Feb.
Artículo en Checo | MEDLINE | ID: mdl-22463086

RESUMEN

The paper brings an overview of published systematic reviews and meta-analyses concerning the evaluation of the effectiveness of the treatment with insulin pump (CSII) in comparison with multiple daily injections (MDI) in type 1 diabetes mellitus. According to found works CSII leads to slightly lower levels of glycosylated hemoglobin (HbA1c) in patients with type 1 diabetes mellitus against MDI. The levels of HbA1c and the variability of glycaemia during the day on MDI before an initiation of CSII should serve for the prediction of an effect of CSII in particular patient. Type 1 diabetics on CSII have less often hypoglycaemia, higher flexibility of their daily regime and thus higher satisfaction with their treatment against MDI. The daily doses of insulin decrease. The weight of patients is the same or slightly higher after the initiation of CSII. There were not enough information for the assesment of the frequency of adverse reactions. It is necessary to educate each patient not only how to manipulate the particular insulin pump, but also about general recommendations for the treatment of diabetes and the application of insulin.


Asunto(s)
Diabetes Mellitus Tipo 1/tratamiento farmacológico , Hipoglucemiantes/administración & dosificación , Bombas de Infusión Implantables , Insulina/administración & dosificación , Glucemia/análisis , Hemoglobina Glucada/análisis , Humanos , Inyecciones Subcutáneas
3.
Vnitr Lek ; 57(11): 954-8, 2011 Nov.
Artículo en Checo | MEDLINE | ID: mdl-22165703

RESUMEN

A new class of drugs that affect incretin system has been introduced in clinical practice, and renal glucose reabsorption inhibitors are soon to follow. Clinical practice thus has an access to drugs with mechanisms of action that differ from those of the currently available antidiabetics, and extend our ability to influence the multifaceted metabolic disorder associated with the type 2 diabetes. Nonpeptide molecules affecting GLP1 receptor and insulin mimetics are being tested in clinical trials. Research also continues in metabolic modulators of nuclear receptors, glucagon receptor antagonists and cellular glucocorticoid inhibitors. Promising are the compounds that increase glucose utilization (glucokinase activators) and decrease its release (fructose-1,6-diphosphatase inhibitors). Gene therapy is also likely to be used for the treatment of type 2 diabetes and its complications.


Asunto(s)
Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Humanos
4.
Vnitr Lek ; 57(4): 391-5, 2011 Apr.
Artículo en Checo | MEDLINE | ID: mdl-21612066

RESUMEN

Dyspeptic syndrome is a common complication of treatment with antidiabetic drugs. This may be a trivial as well as a very serious complication. Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite and taste disturbances are the most common symptoms of dyspeptic problems in patients treated with metformin. They rarely are a reason for treatment discontinuation. Dyspeptic syndrome is a common complication in patients treated with acarbose, this may be prevented by reduced intake of sucrose. Pneumatosis cystoides intestinalis is a rare complication in acarbose-treated patients. Antiobesity agent orlistat is frequently associated with dyspeptic symptoms, particularly if fat intake is not reduced. Treatment with drugs affecting the incretin system (dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists) is very rarely complicated by acute pancreatitis. Glucagon-like peptide-1 receptor agonists may cause dyspeptic symptoms (nausea, vomiting, diarrhoea) at the beginning of treatment. These complaints usually cease and the treatment usually does not need to be discontinued.


Asunto(s)
Dispepsia/inducido químicamente , Hipoglucemiantes/efectos adversos , Acarbosa/efectos adversos , Humanos , Lactonas/efectos adversos , Metformina/efectos adversos , Orlistat
5.
Vnitr Lek ; 57(4): 335-8, 2011 Apr.
Artículo en Checo | MEDLINE | ID: mdl-21612054

RESUMEN

The paper summarizes current knowledge on the diseases of the oral cavity that may be related to diabetes mellitus. It draws the attention to the symptoms that signify potential association between the oral cavity disease and so far undiagnosed diabetes. Attention is paid to a connection between type 2 diabetes and periodontitis, as it is known that diabetes mellitus may contribute to the development of periodontitis, although a reciprocal link also exists and decompensated diabetes may be improved when periodontitis is cured.


Asunto(s)
Complicaciones de la Diabetes , Enfermedades de la Boca/complicaciones , Diabetes Mellitus Tipo 2/complicaciones , Humanos , Enfermedades de la Boca/diagnóstico
6.
Vnitr Lek ; 57(4): 351-5, 2011 Apr.
Artículo en Checo | MEDLINE | ID: mdl-21612057

RESUMEN

Autonomic neuropathy of the gastrointestinal tract is a common complication of diabetes mellitus. However, it is seldom recognised properly as it is rarely considered. In some patients, it might be asymptomatic or hardly compensatable diabetes can be the only one sign. There are non-invasive diagnostic methods to assess gastric emptying rate (13C-octanoic acid breath test) or myoelectric activity of the stomach (electrogastrography). The principle treatment comprises optimal control of diabetes and use of prokinetics.


Asunto(s)
Complicaciones de la Diabetes/diagnóstico , Complicaciones de la Diabetes/terapia , Vaciamiento Gástrico , Motilidad Gastrointestinal , Gastroparesia/diagnóstico , Gastroparesia/terapia , Diabetes Mellitus/fisiopatología , Gastroparesia/etiología , Gastroparesia/fisiopatología , Humanos
7.
Vnitr Lek ; 56(4): 324-8, 2010 Apr.
Artículo en Checo | MEDLINE | ID: mdl-20465105

RESUMEN

There is an association between vascular complications and diabetes compensation in ambulatory as well as inpatient care. Diagnostics of vascular complications in diabetic patients are linked to increased risk of contrast-induced nephropathy. Treatment of severe vascular complications usually requires hospitalization. Achieving and maintaining target glycaemia is essential. Compensation of hyperglycaemia must be sufficient and timely; the risk of hypoglycaemia must not be ignored. Target glycaemia values must be adjusted individually, insulin administration is usually preferred.


Asunto(s)
Angiopatías Diabéticas/terapia , Glucemia/análisis , Medios de Contraste/efectos adversos , Complicaciones de la Diabetes , Angiopatías Diabéticas/diagnóstico , Angiopatías Diabéticas/diagnóstico por imagen , Nefropatías Diabéticas/inducido químicamente , Humanos , Hipoglucemiantes/uso terapéutico , Radiografía
8.
Cas Lek Cesk ; 148(2): 72-5, 77, 2009.
Artículo en Checo | MEDLINE | ID: mdl-19637441

RESUMEN

Vascular complications represent the most frequent and the most serious complication of diabetes type 1 and type 2. High attention is paid to all manifestations of microangiopathy and macroangiopathy not only in studies of their pathogenesis, but also in numerous clinical reports revealing significant effect of conservative treatment in vascular diseases. It concerns namely microalbuminuria and proteinuria and also to the manifestations of diabetic nephropathy which are largely affected by antihypertensive and fibrate treatment as well as to diabetic retinopathy treatable by fibrates. In the treatment of diabetic microangiopathy a consistent attention must be paid to the treatment of hypertension and dyslipidemia, preferably using combinations of hypolipidemics. Already during selection of antidiabetics, possible vascular effects should be considered. Vascular wall and manifestations of vascular diseases can be positively influenced by so called insulin sensitizers, derivatives of sulphonylurea and metformin. In preparation there exist some other substances for the treatment of diabetic complications. Already now, every medical doctor should be able to select adequate treatment with antihypertensives, hypolipidemics and antidiabetics for the prevention or therapy of vascular diabetic complications.


Asunto(s)
Angiopatías Diabéticas/terapia , Antihipertensivos/uso terapéutico , Angiopatías Diabéticas/complicaciones , Angiopatías Diabéticas/fisiopatología , Humanos , Hipoglucemiantes/efectos adversos , Hipoglucemiantes/uso terapéutico
9.
Vnitr Lek ; 55(4): 425-8, 2009 Apr.
Artículo en Checo | MEDLINE | ID: mdl-19449763

RESUMEN

Currently, insulin sensitizing drugs in the form of metformin as the basic drug are part of the treatment of practically any type II diabetic patient. At the beginning of the therapy, metformin is used; later, insulin sensitizers (PPAR-gamma stimulators) such as rosiglitazone and pioglitazone are often applied. Nowadays, extensive research into new pharmaceuticals is being conducted in the group of insulin sensitizers. So-called double sensitizers, panPPAR sensitizers or PPAR-delta sensitizers, are being developed. The most promising group is of the PPAR-gamma selective modulators.


Asunto(s)
Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Insulina/metabolismo , Diabetes Mellitus Tipo 2/metabolismo , Humanos , PPAR gamma/agonistas , Pioglitazona , Rosiglitazona , Tiazolidinedionas/uso terapéutico
10.
Vnitr Lek ; 54(5): 535-40, 2008 May.
Artículo en Checo | MEDLINE | ID: mdl-18630642

RESUMEN

Metformin is currently recommended as the first-line drug for type 2 diabetic patients once the disease has been diagnosed. In addition to antihyperglycaemic effect, it has other effects which have a positive effect on cardiovascular risk. The greatest risk of metformin treatment is lactate acidosis, but its incidence is very low if the contraindications are observed. In spite of the fact that not all contraindications are observed in practice, the incidence of lactate acidosis demonstrably provoked by metformin does not grow. In spite of ongoing discussion on the subject, contraindications still include all states involving the risk of lactacidosis including renal insufficiency.


Asunto(s)
Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Riñón/efectos de los fármacos , Metformina/uso terapéutico , Acidosis Láctica/inducido químicamente , Animales , Contraindicaciones , Humanos , Hipoglucemiantes/efectos adversos , Metformina/efectos adversos
11.
Vnitr Lek ; 54(5): 475-7, 2008 May.
Artículo en Checo | MEDLINE | ID: mdl-18630630

RESUMEN

Malnutrition is a major problem in chronically ill patients. The combination of diabetes and renal insufficiency increases the risk of malnutrition, also due to dietary interventions associated with the two diseases. Resulting malnutrition intensifies inflammatory activity and further compromises nutrition intake. This results in a vicious circle which significantly reduces the quality of life of the affected patients and increases their mortality. Proper nutritional care for such patients is an integral part of their treatment.


Asunto(s)
Nefropatías Diabéticas/complicaciones , Desnutrición/terapia , Apoyo Nutricional , Insuficiencia Renal/complicaciones , Nefropatías Diabéticas/terapia , Humanos , Desnutrición/etiología
13.
Physiol Res ; 56(6): 749-755, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17087600

RESUMEN

Using non-cholesterol sterols investigation several authors postulated a hypothesis that in the metabolic syndrome cholesterol endogenous synthesis is increased and its absorption decreased. Our study is the first attempt to evaluate the direct relation of cholesterol metabolism to the principal pathogenetic phenomenon of the metabolic syndrome--namely to insulin resistance. We have measured insulin sensitivity by two methods--Quicki (Quantitative Sensitivity Check Index) and intravenous insulin tolerance test (Kitt) and 3 indirect markers--fasting insulin level, fasting C-peptide level and SHBG (sex hormone binding globulin). The investigation was performed in three groups of subjects with a different prevalence of insulin resistance: 72 non-diabetics with ischemic heart disease, 117 young blood donors and 63 type 2 diabetics on diet therapy only. Analyzing altogether 60 relationships--between four sterols (lathosterol, squalene, sitosterol and campesterol) and five markers of insulin resistance in three groups of subjects--we have found only six significant relations between cholesterol synthesis and absorption and insulin resistance in all groups of patients. Our results indicate that there exists a significant relationship between insulin sensitivity and indices of either increased cholesterol synthesis or decreased cholesterol absorption. Insulin resistance explains only a part of both abnormalities mentioned above.


Asunto(s)
Colesterol/metabolismo , Resistencia a la Insulina/fisiología , Esteroles/metabolismo , Adulto , Anciano , Biomarcadores , Colesterol/sangre , Colesterol en la Dieta/metabolismo , Dieta , Femenino , Técnica de Clampeo de la Glucosa , Prueba de Tolerancia a la Glucosa , Humanos , Absorción Intestinal/efectos de los fármacos , Lípidos/sangre , Masculino , Persona de Mediana Edad , Análisis de Regresión , Esteroles/sangre
14.
Vnitr Lek ; 53(5): 512-20, 2007 May.
Artículo en Checo | MEDLINE | ID: mdl-17642435

RESUMEN

Diabetic retinopathy is the most serious diabetic complication. Modern pharmacotherapy offers a wide range of potential treatments (ACE inhibitors, sartans, hypolipidemic drugs, drugs influencing proteinkinase C and vascular endotelial growth factor etc.). Diabetic retinopathy was previously treated surgically but today pharmacotherapy is becoming increasingly important. Undoubtly basic strategy for preventing diabetic retinopathy is antihyperglycemic therapy and normoglycemia.


Asunto(s)
Retinopatía Diabética/tratamiento farmacológico , Humanos
15.
Vnitr Lek ; 52(5): 443-5, 2006 May.
Artículo en Checo | MEDLINE | ID: mdl-16771086

RESUMEN

The important role of diabetologists in management of infections in diabetics is the quality diabetes control and compensation. There are two main arrangements in the management, the correction of the former antidiabetic therapy and the quality nutrition. The insulin resistance is higher by any infection and the insulin requirement is higher in such conditions. It is necessary to stop the metformin therapy, provide basal insulinemia and level up the insulin dose at least by one third. In the heavy infections the continuous intravenous insulin infusion is recommend. The specialities of the infection in diabetics, the prevention of infection and acute diabetes complications are discussed.


Asunto(s)
Complicaciones de la Diabetes/terapia , Diabetes Mellitus/terapia , Infecciones/terapia , Complicaciones de la Diabetes/prevención & control , Humanos
16.
Vnitr Lek ; 52(5): 417-22, 2006 May.
Artículo en Checo | MEDLINE | ID: mdl-16771080

RESUMEN

UNLABELLED: Complicated diabetic defects are difficult to heal and frequently result in leg amputation. We have developed a new and unique system for wound treatment, which is based on combination of high molecular weight sodium hyaluronate with an iodine complex--Hyiodine. The aim of our study was to assess the effect of this new method of wound dressing on infected diabetic defects healing. METHODS: The effect of Hyiodine was studied on 22 patients suffering from complicated foot diabetic wounds. Hyiodine was either spread directly over the wound, or (more frequently) gauze was immersed in Hyiodine and then put on/into the wound. Then several layers of dry gauze covered the wound. RESULTS: Within 2-6 weeks after the onset of treatment all but two defects were filled with granulation tissue. Complete healing was evident in 18 patients within 6-20 weeks after the start of treatment, depending on the wound character, localization and extent. Two patients are still treated by Hyiodine, and significant improvement is apparent on their wound. Treatment was not successful in two subjects with ischemic defects due to simultaneous arterial occlusion. CONCLUSIONS: We can conclude that the hyaluronan-iodine complex Hyiodine is efficient method for treatment of difficult to heal diabetic defects without complete arterial occlusion.


Asunto(s)
Antiinfecciosos Locales/administración & dosificación , Pie Diabético/tratamiento farmacológico , Ácido Hialurónico/administración & dosificación , Yodo/administración & dosificación , Cicatrización de Heridas/efectos de los fármacos , Vendajes , Combinación de Medicamentos , Humanos
17.
Physiol Res ; 64(2): 221-8, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25317681

RESUMEN

The aim of this study was to explore the changes in the adipokines leptin and adiponectin in obese patients with type 1 diabetes mellitus (T1DM) who underwent seven days of fasting and 21 days of low-calorie diet (LCD). The plasma leptin and adiponectin concentrations were measured in 14 obese patients with T1DM at baseline, immediately after 7 days of fasting, and after 21 days of LCD. 13 non-obese patients with T1DM were studied only after an overnight fasting. Bioimpedance technique was used for determination of body composition. Obese T1DM patients lost 6.0 kg (6.0; 6.8) (median, 25 %; 75 %) and decreased their fat tissue after fasting and LCD. Plasma leptin in obese T1DM was significantly higher than in non-obese T1DM patients: 9.10 (5.06; 25.89) vs. 1.71 (1.12; 7.08) microg . l(-1) and transiently decreased immediately after fasting: 3.45 microg . l(-1) (1.47; 7.00), (P<0.05). Adiponectin/leptin ratio in obese T1DM was significantly lower than in non-obese T1DM patients: 0.67 (0.57; 1.49) vs. 3.50 (2.46; 6.30) . 10(3) and transiently increased immediately after fasting: 2.22 (1.26; 3.24) . 10(3), (P<0.05). We conclude that obese patients with T1DM are characterized by hyperleptinemia that is reduced by prolonged fasting, but only slightly affected by low calorie diet.


Asunto(s)
Adiponectina/sangre , Diabetes Mellitus Tipo 1/sangre , Diabetes Mellitus Tipo 1/complicaciones , Leptina/sangre , Obesidad/sangre , Obesidad/etiología , Pérdida de Peso , Tejido Adiposo/patología , Adulto , Composición Corporal , Restricción Calórica , Diabetes Mellitus Tipo 1/dietoterapia , Ayuno , Ácidos Grasos no Esterificados/sangre , Femenino , Glucosa/metabolismo , Técnica de Clampeo de la Glucosa , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven
18.
Nutr Diabetes ; 5: e183, 2015 Nov 02.
Artículo en Inglés | MEDLINE | ID: mdl-26524638

RESUMEN

BACKGROUND: Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. Plasma levels of omentin-1 are decreased in obesity and other insulin-resistant states. Insulin resistance contributes to the changes of cholesterol synthesis and absorption as well. The aim of this study was to characterise omentin-1 plasma levels in obese patients with diabetes mellitus type 1 during weight reduction, and to elucidate the relationship between cholesterol metabolism and omentin-1. METHODS: Plasma levels of omentin-1 were measured in obese type 1 diabetics (n=14, body mass index >30 kg m(-2), age 29-62 years) by enzyme-linked immunosorbent assay (BioVendor). Gas chromatography with flame ionisation detector (Fisons Plc.,) was used to measure squalene and non-cholesterol sterols-markers of cholesterol synthesis and absorption (phase I). Measurements were repeated after 1 month (phase II; 1 week of fasting in the hospital setting and 3 weeks on a diet containing 150 g saccharides per day) and after 1 year (phase III) on a diet with 225 g saccharides per day. RESULTS: Omentin-1 plasma levels were stable during phases I and II, but significantly increased (P<0.001) during phase III. Omentin-1 plasma dynamics were significantly associated with plasma levels of high-density lipoprotein (P=0.005) and triacylglycerols (P=0.01), as well as with lathosterol (P=0.03). CONCLUSION: Omentin-1 plasma levels significantly increased during the weight reduction programme. Omentin-1 plasma dynamics suggest a close relationship with cholesterol metabolism.

19.
Cas Lek Cesk ; 140(10): 299-301, 2001 May 24.
Artículo en Checo | MEDLINE | ID: mdl-11411058

RESUMEN

BACKGROUND: The aim of this study was to find the prevalence of osteopenia and osteoporosis in postmenopausal diabetic females and its association with the diabetic compensation and angiopathic complications. METHODS AND RESULTS: Bone mineral density was measured in 156 diabetic females, 44 of them had type 1 diabetes mellitus (mean age 53 +/- 8.9 years) and 112 type 2 (mean age 60 +/- 9.2 years). In the lumbar spine and proximal femur the prevalence of osteoporosis varied between 9-11% and 18-20% respectively. The respective prevalence of osteopenia amounted 30-36% and 34-48%. No statistically significant differences were found between type 1 and type 2 diabetes. Any association with diabetic compensation and the diabetic microangiopathic complications was not found. Only in females with osteoporosis the prevalence of cardiovascular heart disease was higher than in those with normal bone mineral density. CONCLUSION: The prevalence of osteoporosis and osteopenia in postmenopausal diabetic women is similar to those in the common population of the respective age.


Asunto(s)
Enfermedades Óseas Metabólicas/complicaciones , Complicaciones de la Diabetes , Osteoporosis Posmenopáusica/complicaciones , Adulto , Enfermedades Óseas Metabólicas/diagnóstico , Angiopatías Diabéticas/complicaciones , Femenino , Humanos , Persona de Mediana Edad , Osteoporosis Posmenopáusica/diagnóstico
20.
Vnitr Lek ; 48(12): 1118-22, 2002 Dec.
Artículo en Checo | MEDLINE | ID: mdl-12642925

RESUMEN

High standard metabolic compensation of diabetes reduces in a significant way the risk of developmental defects and the perinatal morbidity of children of diabetic mothers and the maternal mortality. A considerable proportion of diabetic women is inadequately informed on the risks of pregnancy. As many as two thirds of pregnancies in diabetic women are unplanned and thus the risk of inadequate compensation of diabetes in early stages of pregnancy increases. Preparation of diabetic women for planned pregnancy is therefore very important. Ensuring long-term normal blood sugar levels in type 1 diabetics has many pitfalls and involves in particular optimal insulin treatment and systematic and high standard control of the blood sugar level and other parameters.


Asunto(s)
Diabetes Mellitus Tipo 1/terapia , Atención Preconceptiva , Embarazo en Diabéticas/terapia , Femenino , Humanos , Insulina/uso terapéutico , Educación del Paciente como Asunto , Embarazo
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