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Histopathology ; 75(1): 128-136, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31155736

RESUMEN

AIMS: Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations. Recent work has shown that grading the extent of LVSI further improves its prognostic strength in patients with stage I endometrioid EC. Despite this, there is little information on the reproducibility of LVSI assessment in EC. Therefore, we designed a study to evaluate interobserver agreement in discriminating true LVSI from LVSI mimics (Phase I) and reproducibility of grading extent of LVSI (Phase II). METHODS AND RESULTS: Scanned haematoxylin and eosin (H&E) slides of endometrioid EC (EEC) with a predefined possible LVSI focus were hosted on a website and assessed by a panel of six European gynaecological pathologists. In Phase I, 48 H&E slides were included for LVSI assessment and in Phase II, 42 H&E slides for LVSI grading. Each observer was instructed to apply the criteria for LVSI used in daily practice. The degree of agreement was measured using the two-way absolute agreement average-measures intraclass correlation coefficient (ICC). Reproducibility of LVSI assessment (ICC = 0.64, P < 0.001) and LVSI grading (ICC = 0.62, P < 0.001) in EEC was substantial among the observers. CONCLUSIONS: Given the good reproducibility of LVSI, this study further supports the important role of LVSI in decision algorithms for adjuvant treatment.


Asunto(s)
Carcinoma Endometrioide/secundario , Neoplasias Endometriales/patología , Metástasis Linfática/patología , Carcinoma Endometrioide/patología , Femenino , Humanos , Metástasis Linfática/diagnóstico , Vasos Linfáticos/patología , Clasificación del Tumor/métodos , Invasividad Neoplásica/diagnóstico , Invasividad Neoplásica/patología , Variaciones Dependientes del Observador , Pronóstico , Reproducibilidad de los Resultados
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